PMID- 31725621 OWN - NLM STAT- MEDLINE DCOM- 20191206 LR - 20221207 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 98 IP - 46 DP - 2019 Nov TI - Longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with T2DM. PG - e17792 LID - 10.1097/MD.0000000000017792 [doi] LID - e17792 AB - OBJECTIVE: The primary aim of this study is to examine the hemodynamics of retrobulbar and intrarenal in the changes of early stage of type 2 diabetes mellitus (T2DM) patients from 2000 to 2015 and to assess incidence associated with diabetic kidney disease (DKD) and diabetic retinopathy (DR). METHOD: Our study contained 60 subjects newly diagnosed of T2DM were divided into 2 groups base on the mean resistive index (RI) (0.7) of hemodynamic and to compare between-group differences of the early changes in hemodynamics of retrobulbar and intrarenal and also to conclude the incidences of diabetic kidney disease (DKD) and diabetic retinopathy (DR)subsequently with a long follow-up duration(2000-2015). First, to compare the mean RI of central retinal artery (CRA) between 2 groups. Second, to compare the mean RI of intrarenal hemodynamics in the bilateral interlobular renal arteries, renal function parameters (blood urea nitrogen (BUN), creatinine (Cr), blood glucose parameters (glycosylated hemoglobinA1c (HbA1c), fasting plasma glucose (FBG), and 2-hour postprandial blood glucose (2hPBG)), glomerular filtration rate (GFR), albumin excretion rate (AER), and urine albumin-to-creatinine ratio (UACR) between 2 groups. RESULTS: First part of our follow-up studies was to compare hemodynamic RI index of retrobulbar in years of 2000 and 2015, both renal function and blood glucose parameters were fund significantly enhanced in subject group RIs 0.7, difference was statistically significant (P < .05). Incidence of HbA1c 0.7, but difference was not statistically significant (P > .05). Incidence of proliferative diabetic retinopathy (PDR) was notably lower in group RIs 0.7, but the difference was not statistically significant (P > .05). Second part of our follow-up studies was to compare hemodynamic RI index of interlobular renal in years of 2000 and 2015, both renal function and blood glucose parameters were fund significantly enhanced in subject group RIs 0.7, difference was statistically significant (P < .05). Incidence of HbA1c 0.7, but difference was not statistically significant (P > .05). Incidence of PDR was notably lower in group RIs 0.7, but the difference was not statistically significant (P > .05). CONCLUSIONS: RIs of retrobulbar and interlobular renal which would serve as a good predictors for the hemodynamics changes in retrobulbar and intrarenal would assess incidence of DKD and DR during the preclinical stage in long-term range excluding renal function and HbA1c in T2DM patients. FAU - Tai, He AU - Tai H AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application. AD - Department of Endocrinology and Metabolic, Liaoning Provincial Corps Hospital of Chinese People's Armed Police Forces. FAU - Jiang, Xiao-Lin AU - Jiang XL AD - College of Combine Traditional Chinese and Western Medicine, Liaoning University of Traditional Chinese Medicine. FAU - Kuang, Jin-Song AU - Kuang JS AD - Department of Endocrinology and Metabolic, Shenyang the Fourth Hospital of People. FAU - Yang, Yu-Feng AU - Yang YF AD - Education and Experimental center, Liaoning University of Traditional Chinese Medicine. FAU - Song, Nan AU - Song N AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application. FAU - Yu, Jj JiaJia AU - Yu JJ AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application. FAU - Cui, Yong AU - Cui Y AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application. FAU - Du, Ying AU - Du Y AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application. FAU - Wu, Yao AU - Wu Y AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application. FAU - Zhang, Han-Wen AU - Zhang HW AD - Education and Experimental center, Liaoning University of Traditional Chinese Medicine. FAU - Cui, Xin-Yue AU - Cui XY AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application. FAU - Li, Na AU - Li N AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application. AD - Department of Endocrinology and Metabolic, Shenyang Children's Hospital. FAU - Zhang, Li-de AU - Zhang LD AD - College of Combine Traditional Chinese and Western Medicine, Liaoning University of Traditional Chinese Medicine. FAU - Fu, Xin AU - Fu X AD - Department of Cardiovascular Medicine, The Second Affiliated Hospital of Shenyang Medical College, Shenyang, China. FAU - Jia, Lian-Qun AU - Jia LQ AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application. FAU - Yang, Guan-Lin AU - Yang GL AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin A) SB - IM MH - Aged MH - Blood Glucose MH - Diabetes Mellitus, Type 2/*complications/*physiopathology MH - Diabetic Nephropathies/*epidemiology/*physiopathology MH - Diabetic Retinopathy/*epidemiology/*physiopathology MH - Female MH - Follow-Up Studies MH - Glycated Hemoglobin MH - Hemodynamics/physiology MH - Humans MH - Kidney/physiopathology MH - Kidney Function Tests MH - Male MH - Middle Aged MH - Renal Artery/physiopathology MH - Retinal Artery/physiopathology PMC - PMC6867759 COIS- The authors have no conflicts of interests to disclose. EDAT- 2019/11/15 06:00 MHDA- 2019/12/18 06:00 PMCR- 2019/11/15 CRDT- 2019/11/15 06:00 PHST- 2019/11/15 06:00 [entrez] PHST- 2019/11/15 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2019/11/15 00:00 [pmc-release] AID - 00005792-201911150-00023 [pii] AID - MD-D-19-00073 [pii] AID - 10.1097/MD.0000000000017792 [doi] PST - ppublish SO - Medicine (Baltimore). 2019 Nov;98(46):e17792. doi: 10.1097/MD.0000000000017792.