PMID- 31727431
OWN - NLM
STAT- MEDLINE
DCOM- 20200907
LR  - 20210101
IS  - 1873-5800 (Electronic)
IS  - 0968-0160 (Print)
IS  - 0968-0160 (Linking)
VI  - 27
IP  - 1
DP  - 2020 Jan
TI  - Association of chemokine expression in anterior cruciate ligament deficient knee 
      with patient characteristics: Implications for post-traumatic osteoarthritis.
PG  - 36-44
LID - S0968-0160(19)30240-6 [pii]
LID - 10.1016/j.knee.2019.10.014 [doi]
AB  - BACKGROUND: Stromal cell-derived factor-1a (SDF-1alpha) and high mobility group box 
      chromosomal protein 1 (HMGB1) are chemokines that can drive post-traumatic 
      osteoarthritis (PTOA) induced by anterior cruciate ligament (ACL) injury. 
      However, the influence of patient characteristics on expression of those 
      chemokines remains unclear. Our aim was to determine the relationship between 
      chemokine expression in synovial fluid (SF) of the ACL-deficient (ACL-D) knee and 
      patient characteristics including time from injury, sex, and age. METHODS: SF 
      samples were collected immediately prior to the first-time ACL reconstruction 
      (ACLR) from 82 patients. Expression of SDF-1alpha and HMGB1 was measured with 
      human-specific solid phase sandwich enzyme-linked immunosorbent assays. The 
      expression levels between groups divided by time from injury, or age, or sex was 
      compared using Student's t-test. The association of SDF-1alpha or HMGB1 levels with 
      those variables was determined using regression analysis and Pearson 
      product-moment correlation coefficient. RESULTS: Regression and correlation 
      analysis indicated significant correlation between SDF-1alpha expression and time 
      from injury in the cohort (r = -0.266, P = 0.016, n = 82) and in females 
      (r = -0.386, P = 0.024, n = 34). Significant correlation was also observed 
      between SDF-1alpha expression and age in the cohort (r = -0.224, P = 0.043, n = 82) 
      and in males (r = -0.289, P = 0.046, n = 48). No significant correlation between 
      HMGB1 expression and patient characteristics was detected. CONCLUSIONS: SDF-1alpha 
      rather than HMGB1 might serve as a protein marker for monitoring the development 
      of PTOA in the ACL-D knee, especially in female patients.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Ding, Lei
AU  - Ding L
AD  - Department of Basic Medical Sciences, Jiangnan University Wuxi College of 
      Medicine, Jiangsu, China; Department of Orthopaedics and Rehabilitation, 
      University of Iowa, Iowa City, IA, USA. Electronic address: 
      Dinglei@jiangnan.edu.cn.
FAU - Amendola, Annunziato
AU  - Amendola A
AD  - Department of Orthopedic Surgery, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Wolf, Brian
AU  - Wolf B
AD  - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, 
      USA.
FAU - Bollier, Matthew
AU  - Bollier M
AD  - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, 
      USA.
FAU - Albright, John
AU  - Albright J
AD  - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, 
      USA.
FAU - Wang, Quanming
AU  - Wang Q
AD  - Department of Orthopedic Surgery, Jiangnan University Affiliated Hospital, 
      Jiangsu, China.
FAU - Wu, Minchen
AU  - Wu M
AD  - Department of Basic Medical Sciences, Jiangnan University Wuxi College of 
      Medicine, Jiangsu, China.
FAU - Wang, Xue
AU  - Wang X
AD  - Department of Basic Medical Sciences, Jiangnan University Wuxi College of 
      Medicine, Jiangsu, China.
FAU - Song, Haiyan
AU  - Song H
AD  - Department of Endocrinology and Metabolism, Second Affiliated Hospital of Harbin 
      Medical University, Harbin, China.
FAU - Pedersen, Douglas
AU  - Pedersen D
AD  - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, 
      USA.
FAU - Martin, James
AU  - Martin J
AD  - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, 
      USA.
LA  - eng
GR  - P50 AR055533/AR/NIAMS NIH HHS/United States
PT  - Journal Article
DEP - 20191111
PL  - Netherlands
TA  - Knee
JT  - The Knee
JID - 9430798
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (HMGB1 Protein)
RN  - 0 (HMGB1 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anterior Cruciate Ligament Injuries/*complications/*metabolism/surgery
MH  - Anterior Cruciate Ligament Reconstruction
MH  - Chemokine CXCL12/*metabolism
MH  - Female
MH  - HMGB1 Protein/*metabolism
MH  - Humans
MH  - Male
MH  - Osteoarthritis, Knee/*etiology/metabolism
MH  - Risk Factors
MH  - Sex Factors
MH  - Synovial Fluid/*metabolism
MH  - Young Adult
PMC - PMC7018575
MID - NIHMS1543683
OTO - NOTNLM
OT  - Anterior cruciate ligament deficient knee
OT  - Chemokines
OT  - High mobility group box chromosomal protein 1 (HMGB1)
OT  - Post-traumatic osteoarthritis (PTOA)
OT  - Stromal cell-derived factor-1a (SDF-1alpha)
OT  - Synovial fluids
COIS- Declaration of competing interest All authors declare that they have no competing 
      interests.
EDAT- 2019/11/16 06:00
MHDA- 2020/09/08 06:00
PMCR- 2021/01/01
CRDT- 2019/11/16 06:00
PHST- 2019/07/19 00:00 [received]
PHST- 2019/08/30 00:00 [revised]
PHST- 2019/10/18 00:00 [accepted]
PHST- 2019/11/16 06:00 [pubmed]
PHST- 2020/09/08 06:00 [medline]
PHST- 2019/11/16 06:00 [entrez]
PHST- 2021/01/01 00:00 [pmc-release]
AID - S0968-0160(19)30240-6 [pii]
AID - 10.1016/j.knee.2019.10.014 [doi]
PST - ppublish
SO  - Knee. 2020 Jan;27(1):36-44. doi: 10.1016/j.knee.2019.10.014. Epub 2019 Nov 11.