PMID- 31728298
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2211-4122 (Print)
IS  - 2347-193X (Electronic)
IS  - 2211-4122 (Linking)
VI  - 29
IP  - 3
DP  - 2019 Jul-Sep
TI  - Cardiac Magnetic Resonance in Primary Prevention of Sudden Cardiac Death.
PG  - 89-94
LID - 10.4103/jcecho.jcecho_25_19 [doi]
AB  - Sudden death accounts for 400,000 deaths annually in the United States. Most 
      sudden deaths are cardiac and are related to arrhythmias secondary to structural 
      heart disease or primary electrical abnormalities of the heart. Implantable 
      cardioverter defibrillator significantly improves survival in patients at 
      increased risk of life-threatening arrhythmias, but better selection of eligible 
      patients is required to avoid unnecessary implantation and identify those 
      patients who may benefit most from this therapy. Left ventricular (LV) ejection 
      fraction (EF) measured by echocardiography has been considered the most reliable 
      parameter for long-term outcome in many cardiac diseases. However, LVEF is an 
      inaccurate parameter for arrhythmic risk assessment as patients with normal or 
      mildly reduced LV systolic function could experience sudden cardiac death (SCD). 
      Among other tools for arrhythmic stratification, magnetic resonance (CMR) 
      provides the most comprehensive cardiac evaluation including in vivo tissue 
      characterization and significantly aids in the identification of patients at 
      higher SCD risk. Most of the evidence are related to late gadolinium enhancement 
      (LGE), which was proven to detect cardiac fibrosis. LGE has been reported to add 
      incremental value for prognostic stratification and SCD prediction across a wide 
      range of cardiac diseases, including both ischemic and nonischemic 
      cardiomyopathies. In addition, T1, T2 mapping and extracellular volume assessment 
      were reported to add incremental value for arrhythmic assessment despite 
      suffering from several technical limitations. CMR should be part of a 
      multiparametric approach for patients' evaluation, and it will play a pivotal 
      role in prognostic stratification according to the current evidence.
CI  - Copyright: (c) 2019 Journal of Cardiovascular Echography.
FAU - Faganello, Giorgio
AU  - Faganello G
AD  - Department of Cardiovascular, Azienda Sanitaria Universitaria Integrata of 
      Trieste, University of Trieste, Trieste, Italy.
FAU - Porcari, Aldostefano
AU  - Porcari A
AD  - Department of Cardiovascular, Azienda Sanitaria Universitaria Integrata of 
      Trieste, University of Trieste, Trieste, Italy.
FAU - Biondi, Federico
AU  - Biondi F
AD  - Department of Cardiovascular, Azienda Sanitaria Universitaria Integrata of 
      Trieste, University of Trieste, Trieste, Italy.
FAU - Merlo, Marco
AU  - Merlo M
AD  - Department of Cardiovascular, Azienda Sanitaria Universitaria Integrata of 
      Trieste, University of Trieste, Trieste, Italy.
FAU - Luca, Antonio De
AU  - Luca A
AD  - Department of Cardiovascular, Azienda Sanitaria Universitaria Integrata of 
      Trieste, University of Trieste, Trieste, Italy.
FAU - Vitrella, Giancarlo
AU  - Vitrella G
AD  - Department of Cardiovascular, Azienda Sanitaria Universitaria Integrata of 
      Trieste, University of Trieste, Trieste, Italy.
FAU - Belgrano, Manuel
AU  - Belgrano M
AD  - Department of Radiology, Azienda Sanitaria Universitaria Integrata of Trieste, 
      University of Trieste, Trieste, Italy.
FAU - Pagnan, Lorenzo
AU  - Pagnan L
AD  - Department of Radiology, Azienda Sanitaria Universitaria Integrata of Trieste, 
      University of Trieste, Trieste, Italy.
FAU - Di Lenarda, Andrea
AU  - Di Lenarda A
AD  - Department of Cardiovascular, Azienda Sanitaria Universitaria Integrata of 
      Trieste, University of Trieste, Trieste, Italy.
FAU - Sinagra, Gianfranco
AU  - Sinagra G
AD  - Department of Cardiovascular, Azienda Sanitaria Universitaria Integrata of 
      Trieste, University of Trieste, Trieste, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - J Cardiovasc Echogr
JT  - Journal of cardiovascular echography
JID - 101562228
PMC - PMC6829757
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - late gadolinium enhancement
OT  - primary prevention
OT  - prognostic stratification
OT  - sudden cardiac death
COIS- There are no conflicts of interest.
EDAT- 2019/11/16 06:00
MHDA- 2019/11/16 06:01
PMCR- 2019/07/01
CRDT- 2019/11/16 06:00
PHST- 2019/11/16 06:00 [entrez]
PHST- 2019/11/16 06:00 [pubmed]
PHST- 2019/11/16 06:01 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - JCE-29-89 [pii]
AID - 10.4103/jcecho.jcecho_25_19 [doi]
PST - ppublish
SO  - J Cardiovasc Echogr. 2019 Jul-Sep;29(3):89-94. doi: 10.4103/jcecho.jcecho_25_19.