PMID- 31729251
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1752-0371 (Electronic)
IS  - 1752-0363 (Linking)
VI  - 14
IP  - 1
DP  - 2020 Jan
TI  - A seven long-noncoding RNA signature predicts prognosis of lung squamous cell 
      carcinoma.
PG  - 53-63
LID - 10.2217/bmm-2019-0282 [doi]
AB  - Aim: This study profiled differentially expressed long noncoding RNAs (lncRNAs) 
      in lung squamous cell carcinoma (LSCC) to predict LSCC overall survival (OS) 
      using The Cancer Genome Atlas data. Materials & methods: The RNA-seq and clinical 
      dataset of 475 LSCC patients was retrieved from The Cancer Genome Atlas database 
      and statistically analyzed. Results: There were 67 upregulated and 32 
      downregulated lncRNAs in LSCCs and 12 lncRNAs associated with OS. The 
      seven-lncRNA signature was associated with poor OS and RP11-150O12.6 and 
      CTA-384D8.35 were associated with better OS (p < 0.001). The seven lncRNAs-mRNA 
      interaction network analysis showed their association with 187 protein-coding 
      genes for cancer development, cell migration, adhesion, proliferation, apoptosis, 
      angiogenesis and the MAPK signaling pathways. Conclusion: This seven-lncRNA 
      signature is useful to predict LSCC OS.
FAU - Li, Shuai
AU  - Li S
AD  - Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai 200233, PR China.
FAU - Teng, Yue
AU  - Teng Y
AD  - Department of Radiology, The First Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu 215006, PR China.
FAU - Yuan, Min-Jie
AU  - Yuan MJ
AD  - Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai 200233, PR China.
FAU - Ma, Ting-Ting
AU  - Ma TT
AD  - Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, 
      National Clinical Research Center for Cancer, Tianjin's Clinical Research Center 
      for Cancer, The Key Laboratory of Cancer Prevention & Therapy, Tianjin 300060, PR 
      China.
FAU - Ma, Jian
AU  - Ma J
AD  - Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai 200233, PR China.
FAU - Gao, Xu-Jie
AU  - Gao XJ
AD  - Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, 
      National Clinical Research Center for Cancer, Tianjin's Clinical Research Center 
      for Cancer, The Key Laboratory of Cancer Prevention & Therapy, Tianjin 300060, PR 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191115
PL  - England
TA  - Biomark Med
JT  - Biomarkers in medicine
JID - 101312535
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Biomarkers, Tumor/*genetics/metabolism
MH  - Carcinoma, Squamous Cell/genetics/metabolism/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lung Neoplasms/genetics/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics/metabolism
MH  - RNA, Messenger/*genetics/metabolism
MH  - Survival Rate
OTO - NOTNLM
OT  - biomarker
OT  - gene signature
OT  - lncRNA
OT  - lung SCC
OT  - lung cancer
OT  - prognosis
EDAT- 2019/11/16 06:00
MHDA- 2021/01/12 06:00
CRDT- 2019/11/16 06:00
PHST- 2019/11/16 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2019/11/16 06:00 [entrez]
AID - 10.2217/bmm-2019-0282 [doi]
PST - ppublish
SO  - Biomark Med. 2020 Jan;14(1):53-63. doi: 10.2217/bmm-2019-0282. Epub 2019 Nov 15.