PMID- 31730069
OWN - NLM
STAT- MEDLINE
DCOM- 20200402
LR  - 20200402
IS  - 1539-4794 (Electronic)
IS  - 0146-9592 (Linking)
VI  - 44
IP  - 22
DP  - 2019 Nov 15
TI  - Ultrafine intravascular photoacoustic endoscope with a 0.7  mm diameter probe.
PG  - 5406-5409
LID - 10.1364/OL.44.005406 [doi]
AB  - Intravascular photoacoustic (IVPA) imaging, benefiting from high optical 
      contrast, large imaging depth and absorption specificity, is of great potential 
      for lipid-rich plaque detection. However, the diameters of reported IVPA 
      endoscopes are too big to intervene into the coronary artery branches. Here, by 
      designing an ultracompact house embedded with a side-fire fiber and a miniature 
      single-element ultrasound transducer, we developed an ultrafine IVPA endoscope 
      with a diameter of 0.7 mm aiming at coronary artery branches atherosclerotic 
      plaque detection. The reliability and feasibility of the ultrafine IVPA endoscope 
      was demonstrated by imaging a stent with a 1.6 mm inner diameter. Furthermore, 
      the photoacoustic imaging and ultrasound imaging of a mouse thoracic aorta with 
      an inner diameter of 1.15 mm was conducted to verify the clinical potentiality of 
      the endoscope, and the PA images have good consistency with histological staining 
      results. To the best of our knowledge, this is the first time we have achieved 
      the IVPA imaging in fine vessel by the 0.7 mm diameter ultrafine photoacoustic 
      endoscope, which paved a way for the translation of the IVPA endoscope to 
      clinical application.
FAU - Lei, Peng
AU  - Lei P
FAU - Wen, Xue
AU  - Wen X
FAU - Wang, Lei
AU  - Wang L
FAU - Zhang, Pengfei
AU  - Zhang P
FAU - Yang, Sihua
AU  - Yang S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Opt Lett
JT  - Optics letters
JID - 7708433
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/*diagnostic imaging
MH  - *Endoscopes
MH  - Equipment Design
MH  - Mice
MH  - Photoacoustic Techniques/*instrumentation
MH  - Transducers
EDAT- 2019/11/16 06:00
MHDA- 2020/04/03 06:00
CRDT- 2019/11/16 06:00
PHST- 2019/11/16 06:00 [entrez]
PHST- 2019/11/16 06:00 [pubmed]
PHST- 2020/04/03 06:00 [medline]
AID - 422863 [pii]
AID - 10.1364/OL.44.005406 [doi]
PST - ppublish
SO  - Opt Lett. 2019 Nov 15;44(22):5406-5409. doi: 10.1364/OL.44.005406.