PMID- 31730801 OWN - NLM STAT- MEDLINE DCOM- 20210526 LR - 20210526 IS - 1872-9738 (Electronic) IS - 0892-0362 (Print) IS - 0892-0362 (Linking) VI - 79 DP - 2020 May-Jun TI - Sex-specific effects of perinatal FireMaster(R) 550 (FM 550) exposure on socioemotional behavior in prairie voles. PG - 106840 LID - S0892-0362(19)30110-2 [pii] LID - 10.1016/j.ntt.2019.106840 [doi] AB - The rapidly rising incidence of neurodevelopmental disorders with social deficits is raising concern that developmental exposure to environmental contaminants may be contributory. Firemaster 550 (FM 550) is one of the most prevalent flame-retardant (FR) mixtures used in foam-based furniture and baby products and contains both brominated and organophosphate components. We and others have published evidence of developmental neurotoxicity and sex specific effects of FM 550 on anxiety-like and exploratory behaviors. Using a prosocial animal model, we investigated the impact of perinatal FM 550 exposure on a range of socioemotional behaviors including anxiety, attachment, and memory. Virtually unknown to toxicologists, but widely used in the behavioral neurosciences, the prairie vole (Microtus ochrogaster) is a uniquely valuable model organism for examining environmental factors on sociality because this species is spontaneously prosocial, biparental, and displays attachment behaviors including pair bonding. Dams were exposed to 0, 500, 1000, or 2000 mug of FM 550 via subcutaneous (sc) injections throughout gestation, and pups were directly exposed beginning the day after birth until weaning. Adult offspring of both sexes were then subjected to multiple tasks including open field, novel object recognition, and partner preference. Effects were dose responsive and sex-specific, with females more greatly affected. Exposure-related outcomes in females included elevated anxiety, decreased social interaction, decreased exploratory motivation, and aversion to novelty. Exposed males also had social deficits, with males in all three dose groups failing to show a partner preference. Our studies demonstrate the utility of the prairie vole for investigating the impact of chemical exposures on social behavior and support the hypothesis that developmental FR exposure impacts the social brain. Future studies will probe the possible mechanisms by which these effects arise. CI - Copyright (c) 2019 Elsevier Inc. All rights reserved. FAU - Gillera, Sagi Enicole A AU - Gillera SEA AD - Department of Biological Sciences, NC State University, Raleigh, NC 27695, USA. FAU - Marinello, William P AU - Marinello WP AD - Department of Biological Sciences, NC State University, Raleigh, NC 27695, USA. FAU - Horman, Brian M AU - Horman BM AD - Department of Biological Sciences, NC State University, Raleigh, NC 27695, USA. FAU - Phillips, Allison L AU - Phillips AL AD - Nicholas School of the Environment, Levine Science Research Center, Duke University, Durham, NC 27710, USA. FAU - Ruis, Matthew T AU - Ruis MT AD - Nicholas School of the Environment, Levine Science Research Center, Duke University, Durham, NC 27710, USA. FAU - Stapleton, Heather M AU - Stapleton HM AD - Nicholas School of the Environment, Levine Science Research Center, Duke University, Durham, NC 27710, USA. FAU - Reif, David M AU - Reif DM AD - Center for Human Health and the Environment, NC State University, Raleigh, NC 27695, USA; Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27695, USA. FAU - Patisaul, Heather B AU - Patisaul HB AD - Department of Biological Sciences, NC State University, Raleigh, NC 27695, USA; Center for Human Health and the Environment, NC State University, Raleigh, NC 27695, USA. Electronic address: hbpatisa@ncsu.edu. LA - eng GR - P30 ES025128/ES/NIEHS NIH HHS/United States GR - R01 ES016099/ES/NIEHS NIH HHS/United States GR - R01 ES028110/ES/NIEHS NIH HHS/United States GR - T32 ES021432/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20191112 PL - United States TA - Neurotoxicol Teratol JT - Neurotoxicology and teratology JID - 8709538 RN - 0 (Firemaster 550) RN - 0 (Flame Retardants) RN - 0 (Organophosphates) RN - 0 (Polybrominated Biphenyls) SB - IM MH - Animals MH - Anxiety/chemically induced MH - Arvicolinae MH - Behavior, Animal/*drug effects MH - Exploratory Behavior/drug effects MH - Female MH - Flame Retardants/*toxicity MH - Male MH - Organophosphates/*toxicity MH - Polybrominated Biphenyls/*toxicity MH - Pregnancy MH - Prenatal Exposure Delayed Effects/*chemically induced/*psychology MH - *Sex Characteristics MH - Social Behavior PMC - PMC7214199 MID - NIHMS1543271 OTO - NOTNLM OT - Anxiety OT - Brain OT - Endocrine disrupting chemicals OT - Endocrine disruptors OT - Flame retardants OT - Neural OT - Neurodevelopment OT - Social COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2019/11/16 06:00 MHDA- 2021/05/27 06:00 PMCR- 2021/05/01 CRDT- 2019/11/16 06:00 PHST- 2019/08/22 00:00 [received] PHST- 2019/10/27 00:00 [revised] PHST- 2019/10/28 00:00 [accepted] PHST- 2019/11/16 06:00 [pubmed] PHST- 2021/05/27 06:00 [medline] PHST- 2019/11/16 06:00 [entrez] PHST- 2021/05/01 00:00 [pmc-release] AID - S0892-0362(19)30110-2 [pii] AID - 10.1016/j.ntt.2019.106840 [doi] PST - ppublish SO - Neurotoxicol Teratol. 2020 May-Jun;79:106840. doi: 10.1016/j.ntt.2019.106840. Epub 2019 Nov 12.