PMID- 31730832
OWN - NLM
STAT- MEDLINE
DCOM- 20210209
LR  - 20210209
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 157
IP  - 4
DP  - 2020 Apr
TI  - Validation of the COPD Assessment Test (CAT) as an Outcome Measure in 
      Bronchiectasis.
PG  - 815-823
LID - S0012-3692(19)34198-4 [pii]
LID - 10.1016/j.chest.2019.10.030 [doi]
AB  - BACKGROUND: Objective assessment of symptoms in bronchiectasis is important for 
      research and in clinical practice. The COPD Assessment Test (CAT) is a short, 
      simple assessment tool widely used in COPD. The items included in the CAT are not 
      specific to COPD and also reflect the dominant symptoms of bronchiectasis. We 
      therefore performed a study to validate the CAT as an outcome measure in 
      bronchiectasis. METHODS: The CAT was administered to two cohorts of 
      bronchiectasis patients along with other quality of life questionnaires. Patients 
      underwent comprehensive clinical assessment. One cohort had repeated 
      questionnaires collected before-and-after treatment of acute exacerbations. We 
      analyzed convergent validity, repeatability, and responsiveness of the score and 
      calculated the minimum clinically important difference (MCID) using a combination 
      of distribution and anchor-based methods. RESULTS: In both cohorts there were 
      positive correlations between the CAT and the St. George's Respiratory 
      Questionnaire (r = 0.90, P < .0001 and r = 0.87, P < .0001). There was an inverse 
      relationship between CAT and Quality of Life - Bronchiectasis Respiratory 
      Symptoms Scale (r = -0.75, P < .0001) and Leicester Cough Questionnaire score 
      (r = -0.77, P < .0001). Patients with more severe disease, based on the 
      bronchiectasis severity index, had significantly higher CAT scores. CAT also 
      correlated with FEV(1) % predicted and 6-min walk distance (6MWD). CAT increased 
      significantly at exacerbation and fell at recovery. The intraclass correlation 
      coefficient for two measurements four-weeks apart while clinically stable was 
      0.88 (95% CI, 0.73-0.95, P < .0001). An MCID of 4 was most consistent. 
      CONCLUSIONS: CAT is a valid, responsive symptom assessment tool in 
      bronchiectasis. The MCID is estimated as 4 points.
CI  - Copyright (c) 2019 American College of Chest Physicians. Published by Elsevier Inc. 
      All rights reserved.
FAU - Finch, Simon
AU  - Finch S
AD  - Scottish Centre for Respiratory Research, University of Dundee, Ninewells 
      Hospital and Medical School, Dundee, Scotland.
FAU - Laska, Irena F
AU  - Laska IF
AD  - Scottish Centre for Respiratory Research, University of Dundee, Ninewells 
      Hospital and Medical School, Dundee, Scotland.
FAU - Abo-Leyah, Hani
AU  - Abo-Leyah H
AD  - Scottish Centre for Respiratory Research, University of Dundee, Ninewells 
      Hospital and Medical School, Dundee, Scotland.
FAU - Fardon, Thomas C
AU  - Fardon TC
AD  - Scottish Centre for Respiratory Research, University of Dundee, Ninewells 
      Hospital and Medical School, Dundee, Scotland.
FAU - Chalmers, James D
AU  - Chalmers JD
AD  - Scottish Centre for Respiratory Research, University of Dundee, Ninewells 
      Hospital and Medical School, Dundee, Scotland. Electronic address: 
      jchalmers@dundee.ac.uk.
LA  - eng
GR  - CAF/16/09/CSO_/Chief Scientist Office/United Kingdom
GR  - SCAF/17/03/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20191112
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
CIN - Chest. 2020 Apr;157(4):749-750. PMID: 32252918
MH  - Bronchiectasis/*diagnosis/physiopathology/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care/methods/standards
MH  - Pulmonary Disease, Chronic Obstructive/*diagnosis/physiopathology/psychology
MH  - *Quality of Life
MH  - Recurrence
MH  - Reproducibility of Results
MH  - Respiratory Function Tests/methods
MH  - Severity of Illness Index
MH  - *Surveys and Questionnaires
MH  - Symptom Assessment/methods
MH  - Symptom Flare Up
MH  - Walk Test/methods
PMC - PMC7118240
OTO - NOTNLM
OT  - bronchiectasis
OT  - outcomes
OT  - questionnaire
OT  - severity
EDAT- 2019/11/16 06:00
MHDA- 2021/02/10 06:00
PMCR- 2019/11/12
CRDT- 2019/11/16 06:00
PHST- 2019/07/15 00:00 [received]
PHST- 2019/10/08 00:00 [revised]
PHST- 2019/10/13 00:00 [accepted]
PHST- 2019/11/16 06:00 [pubmed]
PHST- 2021/02/10 06:00 [medline]
PHST- 2019/11/16 06:00 [entrez]
PHST- 2019/11/12 00:00 [pmc-release]
AID - S0012-3692(19)34198-4 [pii]
AID - 10.1016/j.chest.2019.10.030 [doi]
PST - ppublish
SO  - Chest. 2020 Apr;157(4):815-823. doi: 10.1016/j.chest.2019.10.030. Epub 2019 Nov 
      12.