PMID- 31730901
OWN - NLM
STAT- MEDLINE
DCOM- 20200619
LR  - 20211204
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 469
DP  - 2020 Jan 28
TI  - TRAF7 enhances ubiquitin-degradation of KLF4 to promote hepatocellular carcinoma 
      progression.
PG  - 380-389
LID - S0304-3835(19)30567-1 [pii]
LID - 10.1016/j.canlet.2019.11.012 [doi]
AB  - The tumor necrosis factor receptor-associated factor 7 (TRAF7) is a component of 
      the tumor necrosis factor alpha (TNF-alpha)/nuclear factor kappa B (NF-kappaB) pathway 
      and is a putative E3-ubiquitin ligase. Based on importance of chronic 
      inflammation in hepatocellular carcinoma (HCC), we investigated the biological 
      effects and the molecular mechanisms of deregulated TRAF7 signaling in HCC. Our 
      results showed that high TRAF7 expression in HCC samples was inversely associated 
      with Kruppel-like factor 4 (KLF4) expression and the prognosis of HCC patients. 
      TRAF7 could degrade KLF4 protein through ubiquitin by interacting with its 
      N-terminus. The up-regulation of TRAF7 promoted HCC cell migration and invasion 
      in vivo and in vitro, and TRAF7 knockdown had the opposite effects. Restoration 
      of KLF4 abrogated the motility promotion induced by TRAF7. TRAF7 promotes HCC 
      cell motility through inducing KLF4 protein turnover.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - He, Huan
AU  - He H
AD  - State Key Lab of Molecular Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, 100021, China; Department of 
      Immunology, National Cancer Center/National Clinical Research Center for 
      Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100021, China.
FAU - Wu, Zhiyuan
AU  - Wu Z
AD  - State Key Lab of Molecular Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, 100021, China; Department of 
      Immunology, National Cancer Center/National Clinical Research Center for 
      Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100021, China.
FAU - Li, Sheng
AU  - Li S
AD  - Department of Cell Biology, Key Laboratory of Carcinogenesis and Translational 
      Research (Ministry of Education), Center for Molecular and Translational 
      Medicine, Peking University Cancer Hospital and Institute, Beijing, 100142, 
      China.
FAU - Chen, Kun
AU  - Chen K
AD  - State Key Lab of Molecular Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, 100021, China; Department of 
      Immunology, National Cancer Center/National Clinical Research Center for 
      Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100021, China.
FAU - Wang, Dongmei
AU  - Wang D
AD  - State Key Lab of Molecular Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, 100021, China; Department of 
      Immunology, National Cancer Center/National Clinical Research Center for 
      Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100021, China.
FAU - Zou, Haojing
AU  - Zou H
AD  - State Key Lab of Molecular Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, 100021, China.
FAU - Chen, Hongyan
AU  - Chen H
AD  - State Key Lab of Molecular Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, 100021, China.
FAU - Li, Yi
AU  - Li Y
AD  - State Key Lab of Molecular Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, 100021, China.
FAU - Liu, Zhihua
AU  - Liu Z
AD  - State Key Lab of Molecular Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, 100021, China. Electronic address: 
      liuzh@cicams.ac.cn.
FAU - Qu, Chunfeng
AU  - Qu C
AD  - State Key Lab of Molecular Oncology, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, 100021, China; Department of 
      Immunology, National Cancer Center/National Clinical Research Center for 
      Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100021, China. Electronic address: quchf@cicams.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191112
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (NF-kappa B)
RN  - 0 (TRAF7 protein, human)
RN  - 0 (Tumor Necrosis Factor Receptor-Associated Peptides and Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Carcinoma, Hepatocellular/*genetics/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Disease Progression
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Heterografts
MH  - Humans
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/*genetics
MH  - Liver Neoplasms/*genetics/pathology
MH  - Male
MH  - Mice
MH  - Middle Aged
MH  - NF-kappa B/genetics
MH  - Neoplasm Metastasis
MH  - Prognosis
MH  - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/*genetics
MH  - Tumor Necrosis Factor-alpha/genetics
OTO - NOTNLM
OT  - Liver cancer
OT  - Metastasis
OT  - Ubiquitination
EDAT- 2019/11/16 06:00
MHDA- 2020/06/20 06:00
CRDT- 2019/11/16 06:00
PHST- 2019/06/13 00:00 [received]
PHST- 2019/11/06 00:00 [revised]
PHST- 2019/11/08 00:00 [accepted]
PHST- 2019/11/16 06:00 [pubmed]
PHST- 2020/06/20 06:00 [medline]
PHST- 2019/11/16 06:00 [entrez]
AID - S0304-3835(19)30567-1 [pii]
AID - 10.1016/j.canlet.2019.11.012 [doi]
PST - ppublish
SO  - Cancer Lett. 2020 Jan 28;469:380-389. doi: 10.1016/j.canlet.2019.11.012. Epub 
      2019 Nov 12.