PMID- 31731230
OWN - NLM
STAT- MEDLINE
DCOM- 20200713
LR  - 20200713
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 338
DP  - 2020 Jan 15
TI  - The change of PD1, PDL1 in experimental autoimmune encephalomyelitis treated by 
      1,25(OH)(2)D(3).
PG  - 577079
LID - S0165-5728(19)30418-7 [pii]
LID - 10.1016/j.jneuroim.2019.577079 [doi]
AB  - Experimental autoimmune encephalomyelitis (EAE) is a common animal model that has 
      the same pathology and pathogenesis as multiple sclerosis (MS). Dendritic cells 
      (DCs) exert an important role in central and peripheral tolerance. DCs not only 
      drive T cell priming and differentiation via playing antigen presentation 
      function but mediate the resolution of advancing immune responses with its 
      tolerogenic effect. In this study, we employed 1,25-dihydroxyvitamin D3 
      (1,25(OH)(2)D(3)) to induce tolerogenic dendritic cells (VD3-DCs) revealing their 
      therapeutic effect through an increase in the development of the negative 
      regulatory signaling pathway programmed death 1 (PD1)/programmed death ligand 1 
      (PDL1).
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Cao, Qingqing
AU  - Cao Q
AD  - Department of Neurology, Neuroscience Center, First Hospital of Jilin University, 
      Changchun, China.
FAU - Zheng, Chao
AU  - Zheng C
AD  - Department of Neurology, Neuroscience Center, First Hospital of Jilin University, 
      Changchun, China.
FAU - Xie, Zhongxiang
AU  - Xie Z
AD  - Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China.
FAU - Liu, Lingling
AU  - Liu L
AD  - Department of Neurology, Neuroscience Center, First Hospital of Jilin University, 
      Changchun, China.
FAU - Zhu, Jie
AU  - Zhu J
AD  - Department of Neurology, Neuroscience Center, First Hospital of Jilin University, 
      Changchun, China; Department of Neurobiology, Care Sciences and Society, 
      Karolinska Institute, Stockholm, Sweden.
FAU - Jin, Tao
AU  - Jin T
AD  - Department of Neurology, Neuroscience Center, First Hospital of Jilin University, 
      Changchun, China. Electronic address: drtao.jin@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191031
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (B7-H1 Antigen)
RN  - 0 (Cd274 protein, mouse)
RN  - 0 (Pdcd1 protein, mouse)
RN  - 0 (Programmed Cell Death 1 Receptor)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Animals
MH  - B7-H1 Antigen/*analysis/physiology
MH  - Calcitriol/pharmacology/*therapeutic use
MH  - Dendritic Cells/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/*drug therapy/immunology
MH  - Female
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Multiple Sclerosis/immunology
MH  - Programmed Cell Death 1 Receptor/*analysis/physiology
MH  - T-Lymphocytes/immunology
OTO - NOTNLM
OT  - 1,25-dihydroxyvitamin D(3)
OT  - Experimental autoimmune encephalomyelitis
OT  - Multiple sclerosis
OT  - Programmed death 1
OT  - Programmed death ligand 1
OT  - Tolerogenic dendritic cells
EDAT- 2019/11/16 06:00
MHDA- 2020/07/14 06:00
CRDT- 2019/11/16 06:00
PHST- 2019/08/17 00:00 [received]
PHST- 2019/09/28 00:00 [revised]
PHST- 2019/10/01 00:00 [accepted]
PHST- 2019/11/16 06:00 [pubmed]
PHST- 2020/07/14 06:00 [medline]
PHST- 2019/11/16 06:00 [entrez]
AID - S0165-5728(19)30418-7 [pii]
AID - 10.1016/j.jneuroim.2019.577079 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2020 Jan 15;338:577079. doi: 10.1016/j.jneuroim.2019.577079. Epub 
      2019 Oct 31.