PMID- 31731729
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 11
DP  - 2019 Nov 15
TI  - Interleukin-18 Is a Prognostic Biomarker Correlated with CD8(+) T Cell and 
      Natural Killer Cell Infiltration in Skin Cutaneous Melanoma.
LID - 10.3390/jcm8111993 [doi]
LID - 1993
AB  - Interleukin-18 (IL-18) is a cytokine that enhances innate and adaptive immune 
      responses. Although there are conflicting reports about the roles of IL-18 in 
      melanoma progression, the clinical relevance of IL-18 expression has not been 
      comprehensively studied. In this study, we investigated IL-18 expression and its 
      correlation with patient survival and immune cell infiltration in melanoma using 
      cancer gene expression data publicly available through various databases. IL18 
      mRNA expression was found to be significantly lower in melanoma tissues than 
      normal tissues. Kaplan-Meier survival analysis showed that IL18 expression was 
      positively correlated with patient survival. To investigate the possible 
      mechanisms by which IL18 expression increased patient survival, we then assessed 
      the correlation between IL18 expression and immune cell infiltration levels. 
      Infiltration of various immune cells, especially CD8(+) T and natural killer (NK) 
      cells, which are cytolytic effector cells, was significantly increased by IL18 
      expression. Additionally, the expression levels of two cytolytic molecules 
      including perforin and granzyme B were significantly positively correlated with 
      IL18 expression. Collectively, this study provides the first evidence that IL18 
      expression has prognostic value for melanoma patient survival and is strongly 
      correlated with CD8(+) T and NK cell infiltration, suggesting the role of IL-18 
      as a biomarker for predicting melanoma prognosis.
FAU - Gil, Minchan
AU  - Gil M
AD  - Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 
      05029, Korea.
AD  - Department of Cosmetic Sciences, Sookmyung Women's University, Seoul 04310, 
      Korea.
FAU - Kim, Kyung Eun
AU  - Kim KE
AUID- ORCID: 0000-0003-2201-1280
AD  - Department of Cosmetic Sciences, Sookmyung Women's University, Seoul 04310, 
      Korea.
AD  - Nano-Bio Resources Center, Sookmyung Women's University, Seoul 04310, Korea.
LA  - eng
GR  - 2017R1D1A1B03036390/National Research Foundation of Korea/
GR  - 2017R1D1A1A02018653/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20191115
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6912818
OTO - NOTNLM
OT  - Interleukin-18
OT  - immune infiltrates
OT  - melanoma
OT  - multiomic analysis
OT  - patient survival
COIS- The authors declare no conflict of interest.
EDAT- 2019/11/17 06:00
MHDA- 2019/11/17 06:01
PMCR- 2019/11/15
CRDT- 2019/11/17 06:00
PHST- 2019/10/22 00:00 [received]
PHST- 2019/11/10 00:00 [revised]
PHST- 2019/11/13 00:00 [accepted]
PHST- 2019/11/17 06:00 [entrez]
PHST- 2019/11/17 06:00 [pubmed]
PHST- 2019/11/17 06:01 [medline]
PHST- 2019/11/15 00:00 [pmc-release]
AID - jcm8111993 [pii]
AID - jcm-08-01993 [pii]
AID - 10.3390/jcm8111993 [doi]
PST - epublish
SO  - J Clin Med. 2019 Nov 15;8(11):1993. doi: 10.3390/jcm8111993.