PMID- 31732074
OWN - NLM
STAT- MEDLINE
DCOM- 20201023
LR  - 20201023
IS  - 1873-7145 (Electronic)
IS  - 0963-9969 (Linking)
VI  - 126
DP  - 2019 Dec
TI  - An integrated approach for the valorization of mango seed kernel: Efficient 
      extraction solvent selection, phytochemical profiling and antiproliferative 
      activity assessment.
PG  - 108616
LID - S0963-9969(19)30494-6 [pii]
LID - 10.1016/j.foodres.2019.108616 [doi]
AB  - A novel valorization strategy is proposed in this work for the sustainable 
      utilization of a major mango processing waste (i.e. mango seed kernel, MSK), 
      integrating green pressurized-liquid extraction (PLE), bioactive assays and 
      comprehensive HRMS-based phytochemical characterization to obtain bioactive-rich 
      fractions with high antioxidant capacity and antiproliferative activity against 
      human colon cancer cells. Thus, a two steps PLE procedure was proposed to recover 
      first the non-polar fraction (fatty acids and lipids) and second the polar 
      fraction (polyphenols). Efficient selection of the most suitable solvent for the 
      second PLE step (ethanol/ethyl acetate mixture) was based on the Hansen 
      solubility parameters (HSP) approach. A comprehensive GC- and LC-Q-TOF-MS/MS 
      profiling analysis allowed the complete characterization of the lipidic and 
      phenolic fractions obtained under optimal condition (100% EtOH at 150  degrees C), 
      demonstrating the abundance of oleic and stearic acids, as well as bioactive 
      xanthones, phenolic acids, flavonoids, gallate derivatives and gallotannins. The 
      obtained MSK-extract exhibited higher antiproliferative activity against human 
      colon adenocarcinoma cell line HT-29 compared to traditional extraction 
      procedures described in literature for MSK utilization (e.g. Soxhlet), 
      demonstrating the great potential of the proposed valorization strategy as a 
      valuable opportunity for mango processing industry to deliver a value-added 
      product to the market with health promoting properties.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Ballesteros-Vivas, Diego
AU  - Ballesteros-Vivas D
AD  - High Pressure Laboratory, Department of Chemistry, Faculty of Science, 
      Universidad Nacional de Colombia, Carrera 30 #45-03, Bogota D.C. 111321, 
      Colombia; Laboratory of Foodomics, Institute of Food Science Research, CIAL, 
      CSIC, Nicolas Cabrera 9, 28049 Madrid, Spain.
FAU - Alvarez-Rivera, Gerardo
AU  - Alvarez-Rivera G
AD  - Laboratory of Foodomics, Institute of Food Science Research, CIAL, CSIC, Nicolas 
      Cabrera 9, 28049 Madrid, Spain.
FAU - Morantes, Sandra Johanna
AU  - Morantes SJ
AD  - Unit of Basic Oral Investigation (UIBO), School of Dentistry, Universidad El 
      Bosque, Av. Carrera 9 #131 A-02, Bogota D.C. 110121, Colombia.
FAU - Sanchez-Camargo, Andrea Del Pilar
AU  - Sanchez-Camargo ADP
AD  - High Pressure Laboratory, Department of Chemistry, Faculty of Science, 
      Universidad Nacional de Colombia, Carrera 30 #45-03, Bogota D.C. 111321, 
      Colombia.
FAU - Ibanez, Elena
AU  - Ibanez E
AD  - Laboratory of Foodomics, Institute of Food Science Research, CIAL, CSIC, Nicolas 
      Cabrera 9, 28049 Madrid, Spain.
FAU - Parada-Alfonso, Fabian
AU  - Parada-Alfonso F
AD  - High Pressure Laboratory, Department of Chemistry, Faculty of Science, 
      Universidad Nacional de Colombia, Carrera 30 #45-03, Bogota D.C. 111321, 
      Colombia.
FAU - Cifuentes, Alejandro
AU  - Cifuentes A
AD  - Laboratory of Foodomics, Institute of Food Science Research, CIAL, CSIC, Nicolas 
      Cabrera 9, 28049 Madrid, Spain. Electronic address: a.cifuentes@csic.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190812
PL  - Canada
TA  - Food Res Int
JT  - Food research international (Ottawa, Ont.)
JID - 9210143
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Antioxidants)
RN  - 0 (Industrial Waste)
RN  - 0 (Phenols)
RN  - 0 (Phytochemicals)
RN  - 0 (Plant Extracts)
RN  - 0 (Xanthones)
RN  - 1M84LD0UMD (mangiferin)
SB  - IM
MH  - Antineoplastic Agents, Phytogenic/*pharmacology
MH  - Antioxidants/analysis
MH  - Cell Line
MH  - Cell Proliferation
MH  - Colonic Neoplasms/pathology
MH  - Food Handling/methods
MH  - Fruit
MH  - HT29 Cells
MH  - Humans
MH  - Industrial Waste/*analysis
MH  - Mangifera/*chemistry
MH  - Phenols/analysis
MH  - Phytochemicals/analysis/*pharmacology
MH  - Plant Extracts/*chemistry
MH  - Seeds/*chemistry
MH  - Tandem Mass Spectrometry
MH  - Xanthones/analysis
OTO - NOTNLM
OT  - Antiproliferative activity
OT  - CCD-18Co cell line
OT  - Fruit by-products
OT  - GC-Q-TOF
OT  - HT-29 cell line
OT  - Hansen solubility parameters
OT  - High-resolution mass spectrometry
OT  - LC-Q-TOF
OT  - Mangifera indica L.
OT  - Pressurized-liquid extraction
EDAT- 2019/11/17 06:00
MHDA- 2020/10/24 06:00
CRDT- 2019/11/17 06:00
PHST- 2019/05/24 00:00 [received]
PHST- 2019/08/06 00:00 [revised]
PHST- 2019/08/11 00:00 [accepted]
PHST- 2019/11/17 06:00 [entrez]
PHST- 2019/11/17 06:00 [pubmed]
PHST- 2020/10/24 06:00 [medline]
AID - S0963-9969(19)30494-6 [pii]
AID - 10.1016/j.foodres.2019.108616 [doi]
PST - ppublish
SO  - Food Res Int. 2019 Dec;126:108616. doi: 10.1016/j.foodres.2019.108616. Epub 2019 
      Aug 12.