PMID- 31732285
OWN - NLM
STAT- MEDLINE
DCOM- 20200723
LR  - 20200723
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Linking)
VI  - 40
IP  - 12
DP  - 2019 Dec
TI  - Inhibition-Resistant CARs for NK Cell Cancer Immunotherapy.
PG  - 1078-1081
LID - S1471-4906(19)30213-3 [pii]
LID - 10.1016/j.it.2019.10.004 [doi]
AB  - The promise of natural killer (NK) cells as effectors in cancer cellular therapy 
      is limited by their expression of dominant inhibitory receptors for human 
      leukocyte antigen (HLA) class I. Here, we discuss how chimeric antigen receptors 
      (CARs) engineered to override inhibitory signaling might boost NK cell antitumor 
      responses, independently of blockade of NK cell inhibitory receptors.
CI  - Published by Elsevier Ltd.
FAU - Zhuang, Xiaoxuan
AU  - Zhuang X
AD  - Laboratory of Immunogenetics, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Rockville, MD 20892, USA.
FAU - Long, Eric O
AU  - Long EO
AD  - Laboratory of Immunogenetics, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Rockville, MD 20892, USA. Electronic 
      address: eLong@nih.gov.
LA  - eng
GR  - ZIA AI000525/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20191112
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (Cancer Vaccines)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Chimeric Antigen)
SB  - IM
MH  - Animals
MH  - Cancer Vaccines/*immunology
MH  - Cytotoxicity, Immunologic
MH  - Genetic Engineering
MH  - HLA Antigens/metabolism
MH  - Humans
MH  - Immunotherapy, Adoptive/*methods
MH  - Killer Cells, Natural/*immunology/transplantation
MH  - Neoplasms/immunology/*therapy
MH  - Receptors, Chimeric Antigen/genetics/*metabolism
MH  - Signal Transduction
MH  - T-Lymphocytes, Cytotoxic/immunology/transplantation
EDAT- 2019/11/17 06:00
MHDA- 2020/07/24 06:00
CRDT- 2019/11/17 06:00
PHST- 2019/08/13 00:00 [received]
PHST- 2019/10/12 00:00 [revised]
PHST- 2019/10/16 00:00 [accepted]
PHST- 2019/11/17 06:00 [pubmed]
PHST- 2020/07/24 06:00 [medline]
PHST- 2019/11/17 06:00 [entrez]
AID - S1471-4906(19)30213-3 [pii]
AID - 10.1016/j.it.2019.10.004 [doi]
PST - ppublish
SO  - Trends Immunol. 2019 Dec;40(12):1078-1081. doi: 10.1016/j.it.2019.10.004. Epub 
      2019 Nov 12.