PMID- 31732831
OWN - NLM
STAT- MEDLINE
DCOM- 20200318
LR  - 20200318
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 464
IP  - 1-2
DP  - 2020 Jan
TI  - Analysis of transporter associated with antigen presentation (TAP) genes 
      polymorphisms with HIV-1 infection.
PG  - 65-71
LID - 10.1007/s11010-019-03649-x [doi]
AB  - Human leukocyte antigen (HLA) class I molecules of the human major 
      histocompatibility complex (MHC) play an important role in modulating immune 
      response. HLA class I molecules present antigenic peptides to CD8(+) T cells and 
      thereby play a role in the immune surveillance of cells infected with viruses. 
      TAP1 and TAP2 are MHC-II-encoded genes necessary for the generation of a cellular 
      immune response and polymorphism of these genes can influence the specificity of 
      peptides preferentially presented by the MHC class I molecules and the outcome of 
      the immune response. Several studies implicated genetic variation in TAP genes to 
      various immune-mediated and infectious diseases. To determine the correlation 
      between HIV-1 infection and the TAP1 and TAP2 genes polymorphisms, we performed 
      PCR-RFLP assay of these genes in 500 HIV-1 seropositives and the matched 
      seronegative individuals. Statistical analysis of the data disclosed no 
      correlation between TAP1 (C/T intron 7) gene polymorphism and HIV-1/AIDS disease. 
      However, the current results demonstrated that the heterozygous A/G [OR (95% CI) 
      1.39 (1.06-1.83), P = 0.0171] and homozygous G/G [OR (95% CI) 3.38(1.56-7.46), 
      P = 0.0010] variants of TAP2 (A/G exon 11) (T665A) gene are positively associated 
      with an increased risk of HIV-1/AIDS infection. This case-control analysis might 
      suggest a possible role of TAP2 (A/G exon 11) (T665A) gene in the susceptibility 
      to HIV-1 infection and disease outcome among North Indian patients.
FAU - Abitew, Abaineh Munshea
AU  - Abitew AM
AUID- ORCID: 0000-0002-1469-2189
AD  - Biotechnology Research Institute, Bahir Dar University, P.O. Box 79, Bahir Dar, 
      Ethiopia. abitew2003@yahoo.com.
AD  - Department of Zoology, Panjab University, Chandigarh, India. 
      abitew2003@yahoo.com.
FAU - Sobti, Ranbir Chander
AU  - Sobti RC
AD  - Department of Biotechnology, Panjab University, Chandigarh, India.
FAU - Sharma, Vijay Lakshmi
AU  - Sharma VL
AD  - Department of Zoology, Panjab University, Chandigarh, India.
FAU - Wanchu, Ajay
AU  - Wanchu A
AD  - Department of Internal Medicine, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20191116
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (TAP1 protein, human)
RN  - 145892-13-3 (TAP2 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2/genetics/immunology
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3/*genetics/immunology
MH  - Acquired Immunodeficiency Syndrome/*genetics/immunology
MH  - Adult
MH  - Antigen Presentation/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - *HIV-1
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
PMC - PMC6949311
OTO - NOTNLM
OT  - HIV-1
OT  - HLA
OT  - PCR- RFLP
OT  - Polymorphisms
OT  - TAP1 and TAP2 genes
COIS- All authors declare that they have no conflict of interest.
EDAT- 2019/11/17 06:00
MHDA- 2020/03/19 06:00
PMCR- 2019/11/16
CRDT- 2019/11/17 06:00
PHST- 2019/05/28 00:00 [received]
PHST- 2019/11/03 00:00 [accepted]
PHST- 2019/11/17 06:00 [pubmed]
PHST- 2020/03/19 06:00 [medline]
PHST- 2019/11/17 06:00 [entrez]
PHST- 2019/11/16 00:00 [pmc-release]
AID - 10.1007/s11010-019-03649-x [pii]
AID - 3649 [pii]
AID - 10.1007/s11010-019-03649-x [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2020 Jan;464(1-2):65-71. doi: 10.1007/s11010-019-03649-x. Epub 
      2019 Nov 16.