PMID- 31733044
OWN - NLM
STAT- MEDLINE
DCOM- 20210119
LR  - 20210119
IS  - 2045-7634 (Electronic)
IS  - 2045-7634 (Linking)
VI  - 9
IP  - 1
DP  - 2020 Jan
TI  - Role of human papillomavirus in laryngeal squamous cell carcinoma: A 
      meta-analysis of cohort study.
PG  - 204-214
LID - 10.1002/cam4.2712 [doi]
AB  - OBJECTIVE: To evaluate the association of human papilloma virus (HPV) infection 
      with prognosis, specifically overall survival (OS) and disease-free survival 
      (DFS), in laryngeal squamous cell carcinoma (LSCC) patients. METHOD: A systematic 
      review and meta-analysis were performed according to the Preferred Reporting 
      Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. LSCC was 
      confirmed on the basis of histopathology, whereas HPV status was confirmed by 
      polymerase chain reaction. RESULTS: A total of 6539 articles were initially 
      searched from 8 databases, of which 11 studies were eligible for our review. A 
      total of 1442 LSCC cases were included in this analysis. Eight studies examined 
      3-year OS for LSCC. The pooled hazard ratio (HR) from the 8 studies was 0.29 (95% 
      CI: 0.25-0.33). There was a statistically significant difference in 3-year OS 
      between the HPV-negative and -positive groups, with the latter having a better 
      survival. There was no statistically significant differences in 5- and 10-year 
      OS. Five studies examined 3- and 5-year DFS for LSCC, whereas only 3 studies 
      examined 10-year DFS. There was no statistically significant difference in 3-, 
      5-, and 10-year DFS between the HPV groups. CONCLUSION: This study evaluated the 
      survival impact of HPV infection in LSCC patients. The OS of the HPV-positive 
      group was better than that of the HPV-negative group in terms of short-term 
      survival. Compared with the HPV-negative group, the HPV-positive group had a 
      better trend of DFS, suggesting that a larger sample size and further exploration 
      of the pathology and local control of HPV-positive tumors are needed.
CI  - (c) 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
FAU - Wang, Huanhuan
AU  - Wang H
AUID- ORCID: 0000-0001-6935-0760
AD  - Department of Radiation Oncology, The First Hospital, Jilin University, 
      Changchun, China.
FAU - Wei, Jinlong
AU  - Wei J
AUID- ORCID: 0000-0002-9531-1383
AD  - Department of Radiation Oncology, The First Hospital, Jilin University, 
      Changchun, China.
FAU - Wang, Bin
AU  - Wang B
AUID- ORCID: 0000-0001-9097-4578
AD  - Department of Radiation Oncology, The First Hospital, Jilin University, 
      Changchun, China.
FAU - Meng, Lingbin
AU  - Meng L
AUID- ORCID: 0000-0002-3782-6741
AD  - Department of Internal Medicine, Florida Hospital, Orlando, FL, USA.
FAU - Xin, Ying
AU  - Xin Y
AUID- ORCID: 0000-0001-7591-9423
AD  - Key Laboratory of Pathobiology, Ministry of Education, Jilin University, 
      Changchun, China.
FAU - Dong, Lihua
AU  - Dong L
AUID- ORCID: 0000-0001-7168-4006
AD  - Department of Radiation Oncology, The First Hospital, Jilin University, 
      Changchun, China.
FAU - Jiang, Xin
AU  - Jiang X
AUID- ORCID: 0000-0002-4613-7438
AD  - Department of Radiation Oncology, The First Hospital, Jilin University, 
      Changchun, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20191115
PL  - United States
TA  - Cancer Med
JT  - Cancer medicine
JID - 101595310
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Alphapapillomavirus/genetics/*isolation & purification
MH  - Cohort Studies
MH  - DNA, Viral/isolation & purification
MH  - Disease-Free Survival
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/*mortality/virology
MH  - Papillomavirus Infections/diagnosis/*epidemiology/virology
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - Prognosis
MH  - Risk Factors
MH  - Squamous Cell Carcinoma of Head and Neck/diagnosis/*mortality/virology
PMC - PMC6943161
OTO - NOTNLM
OT  - disease-free survival (DFS)
OT  - human papilloma virus (HPV)
OT  - laryngeal cancer
OT  - laryngeal squamous cell carcinoma (LSCC)
OT  - overall survival (OS)
OT  - squamous cell cancer (SCC)
COIS- None declared.
EDAT- 2019/11/17 06:00
MHDA- 2021/01/20 06:00
PMCR- 2019/11/15
CRDT- 2019/11/17 06:00
PHST- 2019/09/21 00:00 [received]
PHST- 2019/10/25 00:00 [revised]
PHST- 2019/10/28 00:00 [accepted]
PHST- 2019/11/17 06:00 [pubmed]
PHST- 2021/01/20 06:00 [medline]
PHST- 2019/11/17 06:00 [entrez]
PHST- 2019/11/15 00:00 [pmc-release]
AID - CAM42712 [pii]
AID - 10.1002/cam4.2712 [doi]
PST - ppublish
SO  - Cancer Med. 2020 Jan;9(1):204-214. doi: 10.1002/cam4.2712. Epub 2019 Nov 15.