PMID- 31733649
OWN - NLM
STAT- MEDLINE
DCOM- 20200330
LR  - 20200330
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 15
IP  - 1
DP  - 2019 Nov 16
TI  - Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma 
      in a dog.
PG  - 413
LID - 10.1186/s12917-019-2154-8 [doi]
LID - 413
AB  - BACKGROUND: Evolution of indolent to aggressive lymphoma has been described in 
      dogs but is difficult to distinguish from the de novo development of a second, 
      clonally distinct lymphoma. Differentiation of these scenarios can be aided by 
      next generation sequencing (NGS)-based assessment of clonality of lymphocyte 
      antigen receptor genes. CASE PRESENTATION: An 8-year-old male intact Mastiff 
      presented with generalized lymphadenomegaly was diagnosed with nodal T zone 
      lymphoma (TZL) based on cytology, histopathology, immunohistochemistry and flow 
      cytometry. Thirteen months later, the dog re-presented with progressive 
      lymphadenomegaly, and based on cytology and flow cytometry, a large B cell 
      lymphoma (LBCL) was diagnosed. Sequencing-based clonality testing confirmed the 
      de novo development of a LBCL and the persistence of a TZL. CONCLUSIONS: The 
      occurrence of two distinct lymphoid neoplasms should be considered if patient 
      features and tumor cytomorphology or immunophenotype differ among sequential 
      samples. Sequencing-based clonality testing may provide conclusive evidence of 
      two concurrent and distinct clonal lymphocyte populations, termed most 
      appropriately "composite lymphoma".
FAU - Matsuyama, Arata
AU  - Matsuyama A
AD  - Departments of Biomedical Sciences, University of Guelph, Guelph, ON, N1G 2W1, 
      Canada.
FAU - Bienzle, Dorothee
AU  - Bienzle D
AD  - Departments of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada.
FAU - Richardson, Danielle
AU  - Richardson D
AD  - Departments of Clinical Studies, University of Guelph, Guelph, ON, N1G 2W1, 
      Canada.
FAU - Deravi, Nariman
AU  - Deravi N
AD  - Departments of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada.
AD  - Present address: Idexx Laboratories, 1345 Denison St., Markham, ON, L3R 5V2, 
      Canada.
FAU - Hwang, Mei-Hua
AU  - Hwang MH
AD  - Departments of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada.
FAU - Darzentas, Nikos
AU  - Darzentas N
AD  - Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, 
      Germany/Central European Institute of Technology, Masaryk University, Brno, Czech 
      Republic.
FAU - Keller, Stefan M
AU  - Keller SM
AUID- ORCID: 0000-0002-5428-2985
AD  - Departments of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada. 
      smkeller@ucdavis.edu.
AD  - Present address: Department of Pathology, Microbiology, Immunology, University of 
      California, Davis, USA. smkeller@ucdavis.edu.
LA  - eng
GR  - 052523/Pet Trust Foundation Guelph/
GR  - 41835/Pet Trust Foundation Guelph/
GR  - 16-34272A/Ministry of Health of the Czech Republic/
PT  - Case Reports
PT  - Journal Article
DEP - 20191116
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
RN  - 0 (Antineoplastic Agents, Alkylating)
RN  - 0 (Antineoplastic Agents, Hormonal)
RN  - 18D0SL7309 (Chlorambucil)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents, Alkylating/administration & dosage/therapeutic use
MH  - Antineoplastic Agents, Hormonal/administration & dosage/therapeutic use
MH  - Chlorambucil/administration & dosage/therapeutic use
MH  - Dog Diseases/*pathology
MH  - Dogs
MH  - Lymphoma, Large B-Cell, Diffuse/complications/pathology/*veterinary
MH  - Lymphoma, T-Cell/complications/pathology/*veterinary
MH  - Male
MH  - Prednisone/administration & dosage/therapeutic use
PMC - PMC6858704
OTO - NOTNLM
OT  - Antigen receptor gene rearrangement
OT  - Canine
OT  - Clonality
OT  - Composite lymphoma
OT  - Dog
OT  - Lymphoma
OT  - Lymphosarcoma
OT  - PARR
COIS- The authors declare that they have no competing interests.
EDAT- 2019/11/18 06:00
MHDA- 2020/03/31 06:00
PMCR- 2019/11/16
CRDT- 2019/11/18 06:00
PHST- 2019/07/14 00:00 [received]
PHST- 2019/10/23 00:00 [accepted]
PHST- 2019/11/18 06:00 [entrez]
PHST- 2019/11/18 06:00 [pubmed]
PHST- 2020/03/31 06:00 [medline]
PHST- 2019/11/16 00:00 [pmc-release]
AID - 10.1186/s12917-019-2154-8 [pii]
AID - 2154 [pii]
AID - 10.1186/s12917-019-2154-8 [doi]
PST - epublish
SO  - BMC Vet Res. 2019 Nov 16;15(1):413. doi: 10.1186/s12917-019-2154-8.