PMID- 31733748
OWN - NLM
STAT- MEDLINE
DCOM- 20200630
LR  - 20200630
IS  - 1532-9283 (Electronic)
IS  - 1360-8592 (Linking)
VI  - 23
IP  - 4
DP  - 2019 Oct
TI  - Commentary: Statistical significance and clinical significance - A call to 
      consider patient reported outcome measures, effect size, confidence interval and 
      minimal clinically important difference (MCID).
PG  - 690-694
LID - S1360-8592(19)30080-4 [pii]
LID - 10.1016/j.jbmt.2019.02.009 [doi]
AB  - In healthcare research an intervention may be statistically significant based on 
      quantitative analysis; however, simultaneously it may be relatively insignificant 
      to the health or quality of life of patients affected by a particular condition 
      or disease being treated by the intervention - thus may be interpreted as having 
      low clinical significance. An understanding of statistics is fundamental for 
      evidence informed healthcare. Patient-reported outcome measures (PROMs) direct 
      patients to evaluate aspects of their own health, including quality of life, 
      disability and function. Data obtained from PROMs can be used to demonstrate the 
      impact of healthcare interventions on these elements of a person's quality of 
      life. To interpret outcome measure data for clinical decision making, a clinician 
      must understand the concepts of statistical significance and clinical 
      significance. This commentary explores the concepts of patient reported outcome 
      measures (PROMs), their statistical and clinical significance, and explores their 
      relationship with a practical example for the clinician. Limitations of research 
      that only reports p-values and the need to consider effect size, confidence 
      intervals, and minimal clinically important difference are also discussed. 
      Together, these concepts can assist the clinician to evaluate whether an 
      intervention may be suitable for their clinical practice.
CI  - Crown Copyright (c) 2019. Published by Elsevier Ltd. All rights reserved.
FAU - Fleischmann, Michael
AU  - Fleischmann M
AD  - College of Health and Biomedicine, Victoria University, Melbourne, Australia. 
      Electronic address: michael.fleischmann@vu.edu.au.
FAU - Vaughan, Brett
AU  - Vaughan B
AD  - Department of Medical Education, University of Melbourne, Melbourne, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190210
PL  - United States
TA  - J Bodyw Mov Ther
JT  - Journal of bodywork and movement therapies
JID - 9700068
SB  - IM
MH  - Data Interpretation, Statistical
MH  - Humans
MH  - Minimal Clinically Important Difference
MH  - *Patient Reported Outcome Measures
MH  - *Quality of Life
MH  - Research/*organization & administration/*standards
OTO - NOTNLM
OT  - Clinical practice
OT  - Evidence based practice
OT  - Measurement
OT  - Methodology
OT  - Outcomes
OT  - Statistics
EDAT- 2019/11/18 06:00
MHDA- 2020/07/01 06:00
CRDT- 2019/11/18 06:00
PHST- 2019/02/04 00:00 [received]
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/11/18 06:00 [entrez]
PHST- 2019/11/18 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
AID - S1360-8592(19)30080-4 [pii]
AID - 10.1016/j.jbmt.2019.02.009 [doi]
PST - ppublish
SO  - J Bodyw Mov Ther. 2019 Oct;23(4):690-694. doi: 10.1016/j.jbmt.2019.02.009. Epub 
      2019 Feb 10.