PMID- 31734190
OWN - NLM
STAT- MEDLINE
DCOM- 20200714
LR  - 20200714
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 96
DP  - 2020 Feb
TI  - Colorectal diffuse large B-cell lymphoma: molecular subclassification and 
      prognostic significance of immunoglobulin gene translocation.
PG  - 67-78
LID - S0046-8177(19)30168-6 [pii]
LID - 10.1016/j.humpath.2019.09.003 [doi]
AB  - Primary colorectal diffuse large B-cell lymphoma (DLBCL) is rare, and its 
      clinicopathological and genetic features are poorly understood. The aim of our 
      study was to elucidate the frequency and prognostic significance of molecular 
      subgroups in colorectal DLBCL. We examined 25 cases of colorectal lymphoma with 
      DLBCL-like morphology and classified them into germinal center B-cell like 
      (GCB)/non-GCB subgroups by immunohistochemistry (IHC) for CD10, bcl-6 and MUM1, 
      or into double-expressor (DE)/non-DE subgroups by IHC for bcl-2 and c-myc. 
      Translocations involving BCL2, BCL6, MYC, IGH, IGK, IGL, and MALT1 were also 
      investigated using break-apart fluorescence in situ hybridization (FISH). The 25 
      cases were classified into two entities-DLBCL, not otherwise specified (NOS) (n = 
      23; 92%) and high grade B-cell lymphoma, double hit (n = 2; 8%)-according to the 
      recent WHO classification. None of them showed histological evidence of 
      Epstein-Barr virus infection or high-grade transformation from low grade B-cell 
      lymphoma. Ten cases were GCB-type and four cases were DE-type, but these subtypes 
      did not contribute to clinicopathological differences. Translocations involving 
      BCL2, BCL6, MYC, IGH, IGK, IGL, and MALT1 were detected in 3 (12%), 3 (12%), 10 
      (40%), 14 (56%), 3 (12%), 3 (12%), and 0 (0%) of 25 cases, respectively. Of note, 
      the presence of IGH translocation was significantly associated with better 
      overall survival (P = .0053) and progression free survival (P = .0259). 
      Similarly, the translocation involving at least one of the IGs (IGH, IGK, and/or 
      IGL) was associated with more favorable prognosis in DLBCLs or even in DLBCL, 
      NOS. This is the first report to reveal that a small subset of colorectal DLBCL 
      corresponds to double-hit lymphoma. In addition, translocations involving at 
      least one of the IGs may be a favorable prognostic factor in colorectal DLBCL. 
      Testing the translocation involving rearrangement of IGs as well as MYC and 
      BCL2/BCL6 may thus be useful for diagnosis and prognosis.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Hori, Yoshifumi
AU  - Hori Y
AD  - Department of Anatomic Pathology, Kyushu University, Japan.
FAU - Yamamoto, Hidetaka
AU  - Yamamoto H
AD  - Department of Anatomic Pathology, Kyushu University, Japan.
FAU - Nozaki, Yui
AU  - Nozaki Y
AD  - Department of Anatomic Pathology, Kyushu University, Japan.
FAU - Torisu, Takehiro
AU  - Torisu T
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Japan.
FAU - Fujiwara, Minako
AU  - Fujiwara M
AD  - Department of Anatomic Pathology, Kyushu University, Japan.
FAU - Taguchi, Kenichi
AU  - Taguchi K
AD  - Department of Pathology, National Kyushu Cancer Center, Fukuoka, Japan.
FAU - Nishiyama, Kenichi
AU  - Nishiyama K
AD  - Department of Pathology, Fukuoka Red Cross Hospital, Fukuoka, Japan.
FAU - Nakamura, Shotaro
AU  - Nakamura S
AD  - Division of Gastroenterology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Morioka, Japan.
FAU - Kitazono, Takanari
AU  - Kitazono T
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Japan.
FAU - Oda, Yoshinao
AU  - Oda Y
AD  - Department of Anatomic Pathology, Kyushu University, Japan. Electronic address: 
      oda@surgpath.med.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20191115
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (BCL2 protein, human)
RN  - 0 (BCL6 protein, human)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/analysis/*genetics
MH  - Colorectal Neoplasms/classification/*genetics/immunology/pathology
MH  - Female
MH  - *Genes, Immunoglobulin
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Large B-Cell, Diffuse/classification/*genetics/immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Phenotype
MH  - Predictive Value of Tests
MH  - Progression-Free Survival
MH  - Proto-Oncogene Proteins c-bcl-2/genetics
MH  - Proto-Oncogene Proteins c-bcl-6/genetics
MH  - Proto-Oncogene Proteins c-myc/genetics
MH  - Retrospective Studies
MH  - *Translocation, Genetic
OTO - NOTNLM
OT  - Colon
OT  - Diffuse large B-cell lymphoma
OT  - Immunoglobulin
OT  - Prognosis
OT  - Rectum
OT  - Translocation
EDAT- 2019/11/18 06:00
MHDA- 2020/07/15 06:00
CRDT- 2019/11/18 06:00
PHST- 2019/05/21 00:00 [received]
PHST- 2019/09/06 00:00 [revised]
PHST- 2019/09/09 00:00 [accepted]
PHST- 2019/11/18 06:00 [pubmed]
PHST- 2020/07/15 06:00 [medline]
PHST- 2019/11/18 06:00 [entrez]
AID - S0046-8177(19)30168-6 [pii]
AID - 10.1016/j.humpath.2019.09.003 [doi]
PST - ppublish
SO  - Hum Pathol. 2020 Feb;96:67-78. doi: 10.1016/j.humpath.2019.09.003. Epub 2019 Nov 
      15.