PMID- 31734831
OWN - NLM
STAT- MEDLINE
DCOM- 20200811
LR  - 20200811
IS  - 1573-2983 (Electronic)
IS  - 0269-4042 (Linking)
VI  - 42
IP  - 6
DP  - 2020 Jun
TI  - Application of various cytotoxic endpoints for the toxicity prioritization of 
      fine dust (PM2.5) sources using a multi-criteria decision-making approach.
PG  - 1775-1788
LID - 10.1007/s10653-019-00469-2 [doi]
AB  - Fine dust (PM2.5) is generated from various sources, and many studies have 
      reported on the sources of PM2.5. However, the current research on PM2.5 toxicity 
      based on its sources is insufficient. In this study, we developed a framework for 
      the prioritization of fine dust (PM2.5) sources on the basis of the 
      multi-endpoint toxicities using the multi-criteria decision-making method (MCDM). 
      To obtain the multi-endpoint toxicities of PM2.5 sources, cell mortality, 
      reactive oxygen species (ROS), inflammation and mutagenicity were measured for 
      diesel exhaust particles (DEP), gasoline exhaust particles (GEP), rice straw 
      burning particles (RBP), coal combustion particles (CCP) and tunnel dust 
      particles (TDP). The integrative toxicity score (ITS) of the PM2.5 source was 
      calculated using MCDM, which consist of four steps: (1) defining the 
      decision-making matrix, (2) normalization and weighting, (3) calculating the ITS 
      (linear aggregation) and (4) a global sensitivity analysis. The indicator of cell 
      mortality had the highest weight (0.3780) followed by inflammation (0.2471), ROS 
      (0.2178) and mutagenicity (0.1571). Additionally, the ITS based on the sources 
      contributing to PM2.5 resulted in the following order: DEP (0.89), GEP (0.44), 
      RBP (0.40), CCP (0.23) and TDP (0.06). The relative toxicity index (RTI), which 
      represents the ratio of toxicity due to the difference in sources, increases as 
      the contribution of the highly toxic sources increases. The RTI over 1 is closely 
      associated with an increased contribution from highly toxic sources, such as 
      diesel exhaust, gasoline exhaust and biomass burning. It is necessary to 
      investigate the toxicity of various PM2.5 sources and PM2.5 risk based on the 
      sources.
FAU - Kim, Injeong
AU  - Kim I
AD  - School of Earth Sciences and Environmental Engineering, Gwangju Institute of 
      Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of 
      Korea.
AD  - Center for Chemicals Risk Assessment, Gwangju Institute of Science and 
      Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea.
FAU - Park, Kihong
AU  - Park K
AD  - School of Earth Sciences and Environmental Engineering, Gwangju Institute of 
      Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of 
      Korea.
FAU - Lee, KwangYul
AU  - Lee K
AD  - School of Earth Sciences and Environmental Engineering, Gwangju Institute of 
      Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of 
      Korea.
FAU - Park, Minhan
AU  - Park M
AD  - School of Earth Sciences and Environmental Engineering, Gwangju Institute of 
      Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of 
      Korea.
FAU - Lim, Heungbin
AU  - Lim H
AD  - Department of Industrial Plant Science and Technology, Chungbuk National 
      University, Cheongju, Republic of Korea.
FAU - Shin, Hanjae
AU  - Shin H
AD  - R&D Headquarter, KT&G, Daejeon, Republic of Korea.
FAU - Kim, Sang Don
AU  - Kim SD
AD  - School of Earth Sciences and Environmental Engineering, Gwangju Institute of 
      Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of 
      Korea. sdkim@gist.ac.kr.
AD  - Center for Chemicals Risk Assessment, Gwangju Institute of Science and 
      Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea. 
      sdkim@gist.ac.kr.
LA  - eng
GR  - 2014M3C8A5030618/National Research Foundation/
PT  - Journal Article
DEP - 20191116
PL  - Netherlands
TA  - Environ Geochem Health
JT  - Environmental geochemistry and health
JID - 8903118
RN  - 0 (Air Pollutants)
RN  - 0 (Coal)
RN  - 0 (Dust)
RN  - 0 (Particulate Matter)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Vehicle Emissions)
SB  - IM
MH  - Air Pollutants/analysis
MH  - Biomass
MH  - Coal/analysis
MH  - Dust/*analysis
MH  - Environmental Monitoring/*methods
MH  - Particulate Matter/*analysis
MH  - Reactive Oxygen Species/analysis
MH  - Vehicle Emissions/analysis
OTO - NOTNLM
OT  - Cytotoxicity
OT  - Decision-making
OT  - Objective weighting
OT  - PM2.5 sources
OT  - Risk assessment
OT  - Toxicity index
EDAT- 2019/11/18 06:00
MHDA- 2020/08/12 06:00
CRDT- 2019/11/18 06:00
PHST- 2019/04/15 00:00 [received]
PHST- 2019/11/08 00:00 [accepted]
PHST- 2019/11/18 06:00 [pubmed]
PHST- 2020/08/12 06:00 [medline]
PHST- 2019/11/18 06:00 [entrez]
AID - 10.1007/s10653-019-00469-2 [pii]
AID - 10.1007/s10653-019-00469-2 [doi]
PST - ppublish
SO  - Environ Geochem Health. 2020 Jun;42(6):1775-1788. doi: 
      10.1007/s10653-019-00469-2. Epub 2019 Nov 16.