PMID- 31736434
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220531
IS  - 1476-8305 (Electronic)
IS  - 1028-415X (Linking)
VI  - 24
IP  - 11
DP  - 2021 Nov
TI  - Longitudinal study on novel neuropeptides phoenixin, spexin and kisspeptin in 
      adolescent inpatients with anorexia nervosa - association with psychiatric 
      symptoms.
PG  - 896-906
LID - 10.1080/1028415X.2019.1692494 [doi]
AB  - OBJECTIVES: It is hypothesized that novel neuropeptides such as phoenixin (PNX), 
      spexin (SPX), and kisspeptin (KISS) are involved in the pathogenesis of eating 
      disorders. The study presented here analyzed neuropeptide concentrations during 
      the course of anorexia nervosa (AN) and aimed to correlate those values with 
      anthropometric and psychometric measurements. METHODS: A longitudinal study was 
      carried outin 30 AN adolescent patients and 15 age-matched healthy female 
      controls. Selected neuroprotein serum levels were analyzed in malnourished 
      patients (accAN) and following partial weight recovery (norAN), and these values 
      were compared with the control group. RESULTS: In accAN patients, decreased serum 
      PNX levels were detected while SPX serum concentrations were lower in the accAN 
      and norAN patients. No differences were observed in KISS concentrations in all 
      studied groups. CONCLUSIONS: In malnourished adolescent inpatients with AN, serum 
      PNX and SPX level were decreased. The partial weight recovery normalized PNX 
      concentrations but failed to normalize SPX levels. Therefore these two 
      neuropeptides might be crucial for the etiology and course of the AN. The KISS 
      levels did not change in the course of AN. The PNX levels were associated with 
      some symptoms of eating disorders which may indicate its potential contribution 
      in the regulation of emotions and behaviors in AN.
FAU - Palasz, Artur
AU  - Palasz A
AUID- ORCID: 0000-0002-2632-1211
AD  - Department of Histology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Tyszkiewicz-Nwafor, Marta
AU  - Tyszkiewicz-Nwafor M
AUID- ORCID: 0000-0002-0141-4593
AD  - Department of Child and Adolescent Psychiatry, Poznan University of Medical 
      Sciences, Poznan, Poland.
FAU - Suszka-Switek, Aleksandra
AU  - Suszka-Switek A
AUID- ORCID: 0000-0002-4176-7035
AD  - Department of Histology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Bacopoulou, Flora
AU  - Bacopoulou F
AUID- ORCID: 0000-0003-1001-0926
AD  - First Department of Pediatrics, Center for Adolescent Medicine and UNESCO Chair 
      on Adolescent Health Care, School of Medicine, National and Kapodistrian 
      University of Athens, 'Aghia Sophia' Children's Hospital, Athens, Greece.
FAU - Dmitrzak-Weglarz, Monika
AU  - Dmitrzak-Weglarz M
AD  - Department of Psychiatry, Poznan University of Medical Sciences, Psychiatric 
      Genetics Unit, Poznan, Poland.
FAU - Dutkiewicz, Agata
AU  - Dutkiewicz A
AUID- ORCID: 0000-0002-5421-1976
AD  - Department of Child and Adolescent Psychiatry, Poznan University of Medical 
      Sciences, Poznan, Poland.
FAU - Slopien, Agnieszka
AU  - Slopien A
AD  - Department of Child and Adolescent Psychiatry, Poznan University of Medical 
      Sciences, Poznan, Poland.
FAU - Janas-Kozik, Malgorzata
AU  - Janas-Kozik M
AUID- ORCID: 0000-0003-3555-2019
AD  - Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, 
      Medical University of Silesia, Katowice, Poland.
FAU - Wilczynski, Krzysztof M
AU  - Wilczynski KM
AD  - Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, 
      Medical University of Silesia, Katowice, Poland.
FAU - Filipczyk, Lukasz
AU  - Filipczyk L
AUID- ORCID: 0000-0001-9352-0715
AD  - Department of Histology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Bogus, Katarzyna
AU  - Bogus K
AUID- ORCID: 0000-0001-7476-6445
AD  - Department of Histology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Rojczyk, Ewa
AU  - Rojczyk E
AUID- ORCID: 0000-0002-2977-5542
AD  - Department of Descriptive and Topographic Anatomy, School of Medicine with 
      Division of Dentistry in Zabrze, Medical University of Silesia Zabrze, Poland.
FAU - Paszynska, Elzbieta
AU  - Paszynska E
AD  - Department of Integrated Dentistry, Faculty of Conservative Dentistry and 
      Endodontics, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Wiaderkiewicz, Ryszard
AU  - Wiaderkiewicz R
AUID- ORCID: 0000-0001-7309-0121
AD  - Department of Histology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
LA  - eng
PT  - Journal Article
DEP - 20191118
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
RN  - 0 (Kisspeptins)
RN  - 0 (Neuropeptides)
RN  - 0 (Peptide Hormones)
RN  - 0 (SPX protein, human)
SB  - IM
MH  - Adolescent
MH  - *Anorexia Nervosa/psychology
MH  - Female
MH  - Humans
MH  - Inpatients
MH  - Kisspeptins/*blood
MH  - Longitudinal Studies
MH  - *Neuropeptides/blood
MH  - Peptide Hormones/*blood
OTO - NOTNLM
OT  - Anorexia nervosa
OT  - kisspeptin
OT  - phoenixin
OT  - spexin
EDAT- 2019/11/19 06:00
MHDA- 2022/04/01 06:00
CRDT- 2019/11/19 06:00
PHST- 2019/11/19 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2019/11/19 06:00 [entrez]
AID - 10.1080/1028415X.2019.1692494 [doi]
PST - ppublish
SO  - Nutr Neurosci. 2021 Nov;24(11):896-906. doi: 10.1080/1028415X.2019.1692494. Epub 
      2019 Nov 18.