PMID- 31736555
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 0972-2327 (Print)
IS  - 1998-3549 (Electronic)
IS  - 0972-2327 (Linking)
VI  - 22
IP  - 4
DP  - 2019 Oct-Dec
TI  - Diagnostic Utility of Human Leukocyte Antigen B*15:02 Screening in Severe 
      Carbamazepine Hypersensitivity Syndrome.
PG  - 377-383
LID - 10.4103/aian.AIAN_492_18 [doi]
AB  - BACKGROUND: Despite many studies suggesting an association between human 
      leukocyte antigen (HLA)-B*15:02 and carbamazepine (CBZ)-induced severe cutaneous 
      adverse drug reactions essentially toxic epidermal necrolysis (TEN) and 
      Stevens-Johnson syndrome (SJS), the evidence of association in different 
      populations and the degree of association remain uncertain. MATERIALS AND 
      METHODS: The primary analysis was based on population control studies. Data were 
      pooled by means of a random-effects model, and sensitivity, specificity, positive 
      and negative likelihood ratios (LR+ and LR-), diagnostic odds ratios (DOR), and 
      areas under the summary receiver operating characteristic curve (AUC) were 
      calculated. RESULTS: In 23 population control studies, HLA-B*15:02 was measured 
      in 373 patients with CBZ-induced TEN/SJS and 3452 patients without CBZ-induced 
      TEN/SJS. The pooled sensitivity, specificity, LR+, LR-, DOR, and AUC were 0.67 
      (95% confidence interval [CI] = 0.63-0.72), 0.98 (95% CI = 0.98-0.99), 19.73 (95% 
      CI = 10.54-36.92), 0.34 (95% CI = 0.23-0.49), 71.38 (95% CI = 34.89-146.05), and 
      0.96 (95% CI = 0.92-0.98), respectively. Subgroup analyses for Han Chinese, Thai, 
      and Malaysian populations yielded similar findings. Specifically, racial/ethnic 
      subgroup analyses revealed similar findings with respect to DOR for Han Chinese 
      (99.28; 95% CI = 22.20-443.88), Thai (61.01; 95% CI = 23.05-161.44), and 
      Malaysian (30; 95% CI = 7.08-126.68) populations, which are similar to the pooled 
      DOR for the relationship between the HLA-B*15:02 allele and CBZ-induced TEN/SJS 
      across all populations (71.38; 95% CI = 34.89-146.05). CONCLUSIONS: The present 
      study reveals that CBZ is the leading cause of TEN/SJS in many countries. 
      Screening of HLA-B*15:02 may help patients to prevent the occurrence of 
      CBZ-induced TEN/SJS, especially in populations with a higher (>/=5%) risk allele 
      frequency.
CI  - Copyright: (c) 2006 - 2019 Annals of Indian Academy of Neurology.
FAU - Moutaouakkil, Youssef
AU  - Moutaouakkil Y
AD  - Laboratory of Pharmacology-Toxicology, Faculty of Medicine and Pharmacy, Rabat 
      Institute University Mohamed V, Rabat, Morocco.
FAU - Adouani, Badr
AU  - Adouani B
AD  - Laboratory of Pharmacology-Toxicology, Faculty of Medicine and Pharmacy, Rabat 
      Institute University Mohamed V, Rabat, Morocco.
FAU - Cherrah, Yahia
AU  - Cherrah Y
AD  - Laboratory of Pharmacology-Toxicology, Faculty of Medicine and Pharmacy, Rabat 
      Institute University Mohamed V, Rabat, Morocco.
FAU - Lamsaouri, Jamal
AU  - Lamsaouri J
AD  - Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Rabat 
      Institute University Mohamed V, Rabat, Morocco.
FAU - Bousliman, Yassir
AU  - Bousliman Y
AD  - Laboratory of Pharmacology-Toxicology, Faculty of Medicine and Pharmacy, Rabat 
      Institute University Mohamed V, Rabat, Morocco.
LA  - eng
PT  - Journal Article
DEP - 20191025
PL  - India
TA  - Ann Indian Acad Neurol
JT  - Annals of Indian Academy of Neurology
JID - 101273955
PMC - PMC6839291
OTO - NOTNLM
OT  - Carbamazepine
OT  - human leukocyte antigen-B*15:02
OT  - hypersensitivity
OT  - meta-analysis
OT  - screening
COIS- There are no conflicts of interest.
EDAT- 2019/11/19 06:00
MHDA- 2019/11/19 06:01
PMCR- 2019/10/01
CRDT- 2019/11/19 06:00
PHST- 2018/11/30 00:00 [received]
PHST- 2018/12/10 00:00 [revised]
PHST- 2018/12/12 00:00 [accepted]
PHST- 2019/11/19 06:00 [entrez]
PHST- 2019/11/19 06:00 [pubmed]
PHST- 2019/11/19 06:01 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - AIAN-22-377 [pii]
AID - 10.4103/aian.AIAN_492_18 [doi]
PST - ppublish
SO  - Ann Indian Acad Neurol. 2019 Oct-Dec;22(4):377-383. doi: 
      10.4103/aian.AIAN_492_18. Epub 2019 Oct 25.