PMID- 31736936
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20201109
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - Induction of Tolerance and Immunity by Dendritic Cells: Mechanisms and Clinical 
      Applications.
PG  - 2393
LID - 10.3389/fimmu.2019.02393 [doi]
LID - 2393
AB  - Dendritic cells (DCs) are key regulators of immune responses that operate at the 
      interface between innate and adaptive immunity, and defects in DC functions 
      contribute to the pathogenesis of a variety of disorders. For instance, cancer 
      evolves in the context of limited DC activity, and some autoimmune diseases are 
      initiated by DC-dependent antigen presentation. Thus, correcting aberrant DC 
      functions stands out as a promising therapeutic paradigm for a variety of 
      diseases, as demonstrated by an abundant preclinical and clinical literature 
      accumulating over the past two decades. However, the therapeutic potential of 
      DC-targeting approaches remains to be fully exploited in the clinic. Here, we 
      discuss the unique features of DCs that underlie the high therapeutic potential 
      of DC-targeting strategies and critically analyze the obstacles that have 
      prevented the full realization of this promising paradigm.
CI  - Copyright (c) 2019 Fucikova, Palova-Jelinkova, Bartunkova and Spisek.
FAU - Fucikova, Jitka
AU  - Fucikova J
AD  - Sotio, Prague, Czechia.
AD  - Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, 
      Charles University, Prague, Czechia.
FAU - Palova-Jelinkova, Lenka
AU  - Palova-Jelinkova L
AD  - Sotio, Prague, Czechia.
AD  - Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, 
      Charles University, Prague, Czechia.
FAU - Bartunkova, Jirina
AU  - Bartunkova J
AD  - Sotio, Prague, Czechia.
AD  - Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, 
      Charles University, Prague, Czechia.
FAU - Spisek, Radek
AU  - Spisek R
AD  - Sotio, Prague, Czechia.
AD  - Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, 
      Charles University, Prague, Czechia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191029
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Antigen-Presenting Cells/immunology/metabolism
MH  - Autoimmune Diseases/etiology/metabolism/therapy
MH  - Autoimmunity
MH  - Cancer Vaccines/administration & dosage/immunology
MH  - Cell Communication
MH  - Cell Differentiation/genetics/immunology
MH  - Cell Plasticity/genetics/immunology
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Disease Susceptibility
MH  - Humans
MH  - *Immune Tolerance
MH  - *Immunity
MH  - Immunotherapy
MH  - Neoplasms/etiology/metabolism/pathology/therapy
MH  - T-Lymphocytes/immunology/metabolism
MH  - Treatment Outcome
PMC - PMC6830192
OTO - NOTNLM
OT  - autoimmune disorders
OT  - cancer
OT  - dendritic cells
OT  - immunotherapy
OT  - vaccine preparation
EDAT- 2019/11/19 06:00
MHDA- 2020/11/11 06:00
PMCR- 2019/01/01
CRDT- 2019/11/19 06:00
PHST- 2019/07/18 00:00 [received]
PHST- 2019/09/24 00:00 [accepted]
PHST- 2019/11/19 06:00 [entrez]
PHST- 2019/11/19 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.02393 [doi]
PST - epublish
SO  - Front Immunol. 2019 Oct 29;10:2393. doi: 10.3389/fimmu.2019.02393. eCollection 
      2019.