PMID- 31737131
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20200427
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2019
DP  - 2019
TI  - HER2, NF-kappaB, and SATB1 Expression Patterns in Gastric Cancer and Their 
      Correlation with Clinical and Pathological Parameters.
PG  - 6315936
LID - 10.1155/2019/6315936 [doi]
LID - 6315936
AB  - Gastric cancer (GC) is currently recognized as one of the most common and fatal 
      tumor worldwide. The identification of novel biomarkers in relation to clinical 
      information as well as extending the knowledge on a multiple crosstalk between 
      various oncogenic pathways implicated in GC carcinogenesis seems pivotal to limit 
      the disease-associated mortality. Therefore, we assessed the expression of HER2, 
      NF-kappaB, and SATB1 in a total of 104 gastric adenocarcinomas and 30 normal gastric 
      samples and correlated the expression patterns with each other and with some 
      clinicopathological variables. Protein expression was examined by 
      immunohistochemistry (IHC) on tissue microarrays (TMAs), and fluorescence in situ 
      hybridization (FISH) was employed to detect HER2 amplification. In the studied 
      group, HER2 and SATB1 were found to be overexpressed in gastric cancer tissue in 
      comparison to normal gastric mucosa. The expression status of the former protein 
      was seen to differ according to some clinicopathological features, but without 
      statistical significance, whereas the expression of the latter was not 
      importantly associated with any of them. In turn, the NF-kappaB protein level was 
      significantly related to the presence of lymph node metastasis. HER2 expression 
      was not significantly correlated with that of other proteins, but a positive 
      correlation was found between the expression of SATB1 and NF-kappaB. Further studies 
      with a larger group of patients combined with in vitro mechanistic experiments 
      are required to fully elucidate the role and relationship of HER2, NF-kappaB, and 
      SATB1 expression in gastric cancer progression. However, to the best of our 
      knowledge, this study is the first look at a simultaneous evaluation of these 
      three markers in the samples of gastric cancer patients.
CI  - Copyright (c) 2019 Marta Smolinska et al.
FAU - Smolinska, Marta
AU  - Smolinska M
AUID- ORCID: 0000-0003-1327-7087
AD  - Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in 
      Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
FAU - Grzanka, Dariusz
AU  - Grzanka D
AUID- ORCID: 0000-0002-0416-7583
AD  - Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in 
      Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
FAU - Antosik, Paulina
AU  - Antosik P
AUID- ORCID: 0000-0002-7099-8115
AD  - Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in 
      Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
FAU - Kasperska, Anna
AU  - Kasperska A
AUID- ORCID: 0000-0003-0632-3268
AD  - Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in 
      Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
FAU - Neska-Dlugosz, Izabela
AU  - Neska-Dlugosz I
AUID- ORCID: 0000-0001-5899-5328
AD  - Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in 
      Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
FAU - Jozwicki, Jakub
AU  - Jozwicki J
AUID- ORCID: 0000-0002-2771-413X
AD  - Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in 
      Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
FAU - Klimaszewska-Wisniewska, Anna
AU  - Klimaszewska-Wisniewska A
AUID- ORCID: 0000-0002-8493-3806
AD  - Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in 
      Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
LA  - eng
PT  - Journal Article
DEP - 20191014
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Matrix Attachment Region Binding Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (SATB1 protein, human)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adenocarcinoma/metabolism/*pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/metabolism
MH  - Female
MH  - Gastric Mucosa/metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphatic Metastasis
MH  - Male
MH  - Matrix Attachment Region Binding Proteins/*metabolism
MH  - Middle Aged
MH  - NF-kappa B/*metabolism
MH  - Receptor, ErbB-2/genetics/*metabolism
MH  - Stomach Neoplasms/metabolism/*pathology
PMC - PMC6815548
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this article.
EDAT- 2019/11/19 06:00
MHDA- 2020/04/28 06:00
PMCR- 2019/10/14
CRDT- 2019/11/19 06:00
PHST- 2019/02/01 00:00 [received]
PHST- 2019/05/15 00:00 [revised]
PHST- 2019/09/07 00:00 [accepted]
PHST- 2019/11/19 06:00 [entrez]
PHST- 2019/11/19 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
PHST- 2019/10/14 00:00 [pmc-release]
AID - 10.1155/2019/6315936 [doi]
PST - epublish
SO  - Dis Markers. 2019 Oct 14;2019:6315936. doi: 10.1155/2019/6315936. eCollection 
      2019.