PMID- 31741009
OWN - NLM
STAT- MEDLINE
DCOM- 20200217
LR  - 20200217
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 72
IP  - 1-2
DP  - 2020 Feb
TI  - PIRCHE-II: an algorithm to predict indirectly recognizable HLA epitopes in solid 
      organ transplantation.
PG  - 119-129
LID - 10.1007/s00251-019-01140-x [doi]
AB  - Human leukocyte antigen (HLA) mismatches between donors and recipients may lead 
      to alloreactivity after solid organ transplantation. Over the last few decades, 
      our knowledge of the complexity of the HLA system has dramatically increased, as 
      numerous new HLA alleles have been identified. As a result, the likelihood of 
      alloreactive responses towards HLA mismatches after solid organ transplantation 
      cannot easily be assessed. Algorithms are promising solutions to estimate the 
      risk for alloreactivity after solid organ transplantation. In this review, we 
      show that the recently developed PIRCHE-II (Predicted Indirectly ReCognizable HLA 
      Epitopes) algorithm can be used to minimize alloreactivity towards HLA 
      mismatches. Together with the use of other algorithms and simulation approaches, 
      the PIRCHE-II algorithm aims for a better estimated alloreactive risk for 
      individual patients and eventually an improved graft survival after solid organ 
      transplantation.
FAU - Geneugelijk, Kirsten
AU  - Geneugelijk K
AD  - Laboratory of Translational Immunology, University Medical Center Utrecht, 
      Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands. 
      c.c.a.geneugelijk-2@umcutrecht.nl.
FAU - Spierings, Eric
AU  - Spierings E
AUID- ORCID: 0000-0001-9441-1019
AD  - Laboratory of Translational Immunology, University Medical Center Utrecht, 
      Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191118
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Algorithms
MH  - Computational Biology/methods
MH  - Epitopes/*immunology
MH  - Graft Rejection/immunology
MH  - Graft Survival/immunology
MH  - HLA Antigens/genetics/*immunology
MH  - Histocompatibility/*immunology
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Organ Transplantation/methods
MH  - Risk Factors
MH  - Tissue Donors
MH  - Tissue and Organ Procurement
PMC - PMC6971131
OTO - NOTNLM
OT  - Epitopes
OT  - HLA
OT  - Histocompatibility
OT  - Matching
OT  - PIRCHE-II
OT  - Solid organ transplantation
OT  - Transplantation
COIS- The UMCU has filed a patent application on the prediction of an alloimmune 
      response against mismatched HLA. E.S. is listed as inventor on this patent. K.G. 
      has no conflicts of interest to disclose. A 3-month free trial of the PIRCHE 
      algorithm is available via: https://www.pirche.com.
EDAT- 2019/11/20 06:00
MHDA- 2020/02/18 06:00
PMCR- 2019/11/18
CRDT- 2019/11/20 06:00
PHST- 2019/09/06 00:00 [received]
PHST- 2019/10/16 00:00 [accepted]
PHST- 2019/11/20 06:00 [pubmed]
PHST- 2020/02/18 06:00 [medline]
PHST- 2019/11/20 06:00 [entrez]
PHST- 2019/11/18 00:00 [pmc-release]
AID - 10.1007/s00251-019-01140-x [pii]
AID - 1140 [pii]
AID - 10.1007/s00251-019-01140-x [doi]
PST - ppublish
SO  - Immunogenetics. 2020 Feb;72(1-2):119-129. doi: 10.1007/s00251-019-01140-x. Epub 
      2019 Nov 18.