PMID- 31742332
OWN - NLM
STAT- MEDLINE
DCOM- 20210820
LR  - 20210820
IS  - 1529-7268 (Electronic)
IS  - 0006-3363 (Linking)
VI  - 102
IP  - 3
DP  - 2020 Mar 13
TI  - Prenatal exercise reverses high-fat-diet-induced placental alterations and alters 
      male fetal hypothalamus during late gestation in ratsdagger.
PG  - 705-716
LID - 10.1093/biolre/ioz213 [doi]
AB  - Maternal high-fat (HF) diet negatively affects maternal metabolism and placental 
      function. This study aimed to determine whether gestational exercise prevents the 
      effect of HF diet on placental amino acid transporter expression and 
      nutrient-sensing signaling and the fetal response. Pregnant Sprague-Dawley rats 
      were either fed with a CHOW (13.5% fat) or HF (60% fat) diet during gestation and 
      further divided into two subgroups: voluntary exercised and sedentary. Placentae 
      were collected on gestational day (GD) 14 and GD20, and male placentae were used 
      in this study. We found that gestational exercise ameliorated the detrimental 
      effects of HF diet on dams' adiposity, plasma leptin, and insulin concentrations. 
      Maternal exercise did not influence fetoplacental growth but affected male fetal 
      hypothalamic Leprb, Stat3, Insr, Agrp, and Pomc expressions on GD20. Maternal HF 
      diet decreased placental labyrinth thickness and increased system A amino acid 
      transporter SNAT2 expression, while these changes were normalized by exercise. 
      The activation of placental mechanistic target of rapamycin complex 1/4E-BP1 and 
      LepRb/STAT3 signaling might contribute to the increased placental SNAT2 
      expression in HF-fed dams, which were reversed by exercise on GD20. These data 
      highlight that gestational exercise reverses HF-diet-induced placental 
      alterations during late gestation without influencing fetal growth. However, 
      maternal exercise altered fetal hypothalamic gene expression, which may affect 
      long-term offspring health.
CI  - (c) The Author(s) 2019. Published by Oxford University Press on behalf of Society 
      for the Study of Reproduction. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Song, Lin
AU  - Song L
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, 
      Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
AD  - Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education of China, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
FAU - Yan, Jianqun
AU  - Yan J
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, 
      Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
AD  - Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education of China, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
FAU - Wang, Nan
AU  - Wang N
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, 
      Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
FAU - Wei, Xiaojing
AU  - Wei X
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, 
      Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
AD  - Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education of China, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
FAU - Luo, Xiao
AU  - Luo X
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, 
      Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
AD  - Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education of China, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
FAU - Meng, Kai
AU  - Meng K
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, 
      Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
AD  - Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education of China, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
FAU - Sun, Bo
AU  - Sun B
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, 
      Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
AD  - Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education of China, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Agouti-Related Protein)
RN  - 0 (Amino Acid Transport Systems)
RN  - 0 (Receptors, Leptin)
RN  - 0 (STAT3 Transcription Factor)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
RN  - EC 2.7.10.1 (Receptor, Insulin)
SB  - IM
MH  - Agouti-Related Protein/metabolism
MH  - Amino Acid Transport Systems/metabolism
MH  - Animals
MH  - *Diet, High-Fat
MH  - Female
MH  - Fetal Development/physiology
MH  - Hypothalamus/*metabolism
MH  - Male
MH  - Physical Conditioning, Animal/*physiology
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Pro-Opiomelanocortin/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Insulin/metabolism
MH  - Receptors, Leptin/metabolism
MH  - STAT3 Transcription Factor/metabolism
MH  - Sex Factors
OTO - NOTNLM
OT  - fetal development
OT  - mTORC1
OT  - maternal exercise
OT  - placenta
EDAT- 2019/11/20 06:00
MHDA- 2021/08/21 06:00
CRDT- 2019/11/20 06:00
PHST- 2019/09/04 00:00 [received]
PHST- 2019/10/14 00:00 [revised]
PHST- 2019/11/12 00:00 [accepted]
PHST- 2019/11/20 06:00 [pubmed]
PHST- 2021/08/21 06:00 [medline]
PHST- 2019/11/20 06:00 [entrez]
AID - 5631877 [pii]
AID - 10.1093/biolre/ioz213 [doi]
PST - ppublish
SO  - Biol Reprod. 2020 Mar 13;102(3):705-716. doi: 10.1093/biolre/ioz213.