PMID- 31743253
OWN - NLM
STAT- MEDLINE
DCOM- 20200520
LR  - 20200520
IS  - 1537-1611 (Electronic)
IS  - 1522-0443 (Linking)
VI  - 21
IP  - 2
DP  - 2019 Dec
TI  - A Case of Triple-Negative Myasthenia Gravis Lambert-Eaton Overlap Syndrome With 
      Negative Agrin and LRP-4 Antibodies.
PG  - 103-106
LID - 10.1097/CND.0000000000000189 [doi]
AB  - A case of triple-negative myasthenia gravis Lambert-Eaton overlap syndrome with 
      negative Agrin and LRP-4 antibodies. Myasthenia gravis (MG) is an autoimmune 
      disorder that shares similar features with Lambert-Eaton myasthenic syndrome. The 
      combined clinical and electrophysiological findings of MG and Lambert-Eaton 
      myasthenic syndrome have been reported, these cases represent the so-called 
      "myasthenia gravis Lambert-Eaton overlap syndrome" (MLOS). A total of 55 MLOS 
      cases have been identified, 13 cases were reported before the acetylcholine 
      receptor (AChR) antibody (ab) testing era, 14 during the AChR-ab era, 26 during 
      the voltage-gated calcium channel (VGCC)-ab era, and 2 cases have been reported 
      during the muscle-specific kinase (MuSK)-ab era, of these; only 1 patient tested 
      negative for all 3 antibodies. New immunological markers have been identified in 
      the study of MG [Agrin and the low-density lipopro-tein receptor-related protein 
      4 (LRP-4)]. We present a patient with MLOS who tested negative for all 5 (AChR, 
      MuSK, VGCC, Agrin, and LRP-4) serologic markers.
FAU - Maturana, Miguel A
AU  - Maturana MA
AD  - Department of Neurology and Clinical Neurophysiology, Methodist University 
      Hospital, University of Tennessee Health Science Center, Memphis, TN.
FAU - Bertorini, Tulio E
AU  - Bertorini TE
AD  - Department of Neurology and Clinical Neurophysiology, Methodist University 
      Hospital, University of Tennessee Health Science Center, Memphis, TN.
FAU - Mei, Lin
AU  - Mei L
AD  - Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, 
      Augusta University, Augusta, GA.
FAU - Pandhi, Abhi
AU  - Pandhi A
AD  - Department of Neurology and Clinical Neurophysiology, Methodist University 
      Hospital, University of Tennessee Health Science Center, Memphis, TN.
FAU - Mays, William H
AU  - Mays WH
AD  - Department of Neurology and Clinical Neurophysiology, Methodist University 
      Hospital, University of Tennessee Health Science Center, Memphis, TN.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Neuromuscul Dis
JT  - Journal of clinical neuromuscular disease
JID - 100887391
RN  - 0 (Agrin)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (HAPLN4 protein, human)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Agrin/*immunology
MH  - Autoantibodies
MH  - Biomarkers
MH  - Electrodiagnosis
MH  - Extracellular Matrix Proteins/*immunology
MH  - Female
MH  - Humans
MH  - Immunotherapy
MH  - Lambert-Eaton Myasthenic Syndrome/diagnosis/*immunology/therapy
MH  - Middle Aged
MH  - Nerve Tissue Proteins/*immunology
MH  - Treatment Outcome
MH  - Ulnar Nerve/physiopathology
EDAT- 2019/11/20 06:00
MHDA- 2020/05/21 06:00
CRDT- 2019/11/20 06:00
PHST- 2019/11/20 06:00 [entrez]
PHST- 2019/11/20 06:00 [pubmed]
PHST- 2020/05/21 06:00 [medline]
AID - 00131402-201912000-00006 [pii]
AID - 10.1097/CND.0000000000000189 [doi]
PST - ppublish
SO  - J Clin Neuromuscul Dis. 2019 Dec;21(2):103-106. doi: 
      10.1097/CND.0000000000000189.