PMID- 31743809
OWN - NLM
STAT- MEDLINE
DCOM- 20201231
LR  - 20201231
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 70
DP  - 2020 Feb
TI  - Effects of carbohydrate and glutamine supplementation on cytokine production by 
      monocytes after exercise in hypoxia: A crossover, randomized, double-blind pilot 
      study.
PG  - 110592
LID - S0899-9007(19)30176-5 [pii]
LID - 10.1016/j.nut.2019.110592 [doi]
AB  - OBJECTIVES: The aim of this study was to evaluate the combined effects of 
      carbohydrate (CHO) and glutamine (Gln) supplementation on cytokine production by 
      monocytes after exercise until exhaustion performed in hypoxia. METHODS: Fifteen 
      physically active men underwent three exercises until exhaustion with an 
      intensity of 70% maximal oxygen intake at a simulated height of 4500 m under the 
      following supplementation: placebo, CHO (maltodextrin 8%/200 mL for 20 min), and 
      CHO + Gln (Gln 20 g/d for 6 d and maltodextrin 8%/200 mL for 20 min) during 
      exercise and for 2 h of recovery. Analysis of variance for repeated measures 
      followed by the Tukey's post hoc test was realized and P < 0.05 was considered 
      statistically significant. RESULTS: Oxygen saturation of arterial blood (SaO(2)%) 
      decreased in the three trials compared with baseline. Two hours post-exercise, 
      the SaO(2)% was high in CHO + Gln condition compared with placebo. Two hours 
      after exercise, interleukin (IL)-1beta decreased compared with post-exercise in 
      placebo and was lower compared with baseline in the CHO + Gln condition. Tumor 
      necrosis factor-alpha decreased 2 h after exercise compared with baseline and 
      pre-exercise in the CHO + Gln condition. No changes were observed in 
      myeloperoxidase or IL-6 production. Two hours after exercise, Gln decreased 
      compared with baseline and post-exercise in placebo and decreased 2 h after 
      exercise in relation to post-exercise in the CHO condition. Gln increased 
      post-exercise compared with pre-exercise in the CHO + Gln condition. Although 
      erythropoietin did not change in this condition, it was high post-exercise and 2 
      h after exercise in the placebo condition compared with baseline and 2 h after 
      exercise compared with baseline and pre-exercise in the CHO condition. 
      CONCLUSIONS: Gln supplementation for 6 d before exercise, associated with CHO 
      supplementation during exercise, was able to revert Gln reduction after exercise 
      and after 2 h of recovery and may have contributed to reducing tumor necrosis 
      factor-alpha production, suggesting a possible anti-inflammatory effect of 
      supplementation.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Caris, Aline V
AU  - Caris AV
AD  - Universidade Federal de Sao Paulo, Campus Sao Paulo, Brazil.
FAU - Tavares-Silva, Edgar
AU  - Tavares-Silva E
AD  - Universidade Federal de Sao Paulo, Campus Sao Paulo, Brazil.
FAU - Thomatieli-Santos, Ronaldo V
AU  - Thomatieli-Santos RV
AD  - Universidade Federal de Sao Paulo, Campus Baixada Santista, Brazil; Postgraduate 
      program in Psychobiology, Universidade Federal de Sao Paulo, Campus Sao Paulo, 
      Brazil. Electronic address: ronaldo.thomatieli@unifesp.br.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190924
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Cytokines)
RN  - 0 (Dietary Carbohydrates)
RN  - 0RH81L854J (Glutamine)
SB  - IM
MH  - Adult
MH  - Cross-Over Studies
MH  - Cytokines/*biosynthesis
MH  - Dietary Carbohydrates/*administration & dosage
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Exercise/physiology
MH  - Glutamine/*administration & dosage
MH  - Healthy Volunteers
MH  - Humans
MH  - Hypoxia/*physiopathology
MH  - Male
MH  - Monocytes/metabolism
MH  - Oxygen Consumption/drug effects
MH  - Physical Exertion
MH  - Pilot Projects
OTO - NOTNLM
OT  - Carbohydrate
OT  - Glutamine
OT  - Innate response
OT  - Monocytes
OT  - Physical exercise High altitude
EDAT- 2019/11/20 06:00
MHDA- 2021/01/01 06:00
CRDT- 2019/11/20 06:00
PHST- 2019/05/17 00:00 [received]
PHST- 2019/08/24 00:00 [revised]
PHST- 2019/08/25 00:00 [accepted]
PHST- 2019/11/20 06:00 [pubmed]
PHST- 2021/01/01 06:00 [medline]
PHST- 2019/11/20 06:00 [entrez]
AID - S0899-9007(19)30176-5 [pii]
AID - 10.1016/j.nut.2019.110592 [doi]
PST - ppublish
SO  - Nutrition. 2020 Feb;70:110592. doi: 10.1016/j.nut.2019.110592. Epub 2019 Sep 24.