PMID- 31743876
OWN - NLM
STAT- MEDLINE
DCOM- 20200603
LR  - 20200603
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 121
DP  - 2020 Jan
TI  - Microvascular pericytes in brain-associated vascular disease.
PG  - 109633
LID - S0753-3322(19)35255-2 [pii]
LID - 10.1016/j.biopha.2019.109633 [doi]
AB  - Pericytes, as mural cells of microvessels, are important regulators of vascular 
      structure formation and function maintenance in the process of cerebrovascular 
      maturation, cerebrovascular homeostasis and disease. In the recent years, they 
      have gradually become the hot spot of the research. In fact, pericytes are not 
      isolated cells. Their functions can't be played without the cooperation with 
      surrounding cells. In the neurovascular unit (NVU), they communicate with other 
      cells by direct contact or through signaling pathways to regulate cerebral 
      vascular function and the state of blood vessels in response to changes in neural 
      activity. Pericytes are closely related to the cerebrovascular and central 
      nervous system disease. Currently, a large number of clinical and animal studies 
      have confirmed that pericytes biological function is related to cerebral blood 
      flow, blood-brain barrier permeability, cerebral vascular formation maintenance, 
      and neuroinflammation. The objective of this review is to highlight the role of 
      pericytes in cerebral microvessels as well as their relationships with stroke, 
      dementia, and brain tumor disease. The possible pathogenic mechanisms between 
      pericytes and these diseases will also be described. As a matter of fact, the 
      role of pericytes in the brain-associated vascular disease may provide new ideas 
      for clinical treatment.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Liu, Qi
AU  - Liu Q
AD  - First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 
      314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China.
FAU - Yang, Yingxi
AU  - Yang Y
AD  - First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 
      314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China.
FAU - Fan, Xiaonong
AU  - Fan X
AD  - Institute of acupuncture and moxibustion, First Teaching Hospital of Tianjin 
      University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai 
      District, Tianjin 300193, China; Tianjin Key Laboratory of Acupuncture and 
      Moxibustion Science, National Acupuncture Clinical Research Center, China. 
      Electronic address: fanxiaonong@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191125
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/pathology
MH  - Brain/*pathology
MH  - Central Nervous System Diseases/*pathology
MH  - Cerebrovascular Circulation/physiology
MH  - Humans
MH  - Microvessels/*pathology
MH  - Pericytes/*pathology
MH  - Signal Transduction/physiology
OTO - NOTNLM
OT  - Brain-associated vascular disease
OT  - Function
OT  - Pericytes
OT  - Therapy
EDAT- 2019/11/20 06:00
MHDA- 2020/06/04 06:00
CRDT- 2019/11/20 06:00
PHST- 2019/09/26 00:00 [received]
PHST- 2019/10/31 00:00 [revised]
PHST- 2019/11/01 00:00 [accepted]
PHST- 2019/11/20 06:00 [pubmed]
PHST- 2020/06/04 06:00 [medline]
PHST- 2019/11/20 06:00 [entrez]
AID - S0753-3322(19)35255-2 [pii]
AID - 10.1016/j.biopha.2019.109633 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2020 Jan;121:109633. doi: 10.1016/j.biopha.2019.109633. Epub 
      2019 Nov 25.