PMID- 31744348
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20201102
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 130
IP  - 3
DP  - 2020 Mar
TI  - Hyperhomocysteinemia can predict the severity of white matter hyperintensities in 
      elderly lacunar infarction patients.
PG  - 231-236
LID - 10.1080/00207454.2019.1667795 [doi]
AB  - Background and Purpose: Hyperhomocysteinemia (Hhcy) is a risk factor for stroke. 
      Several studies have demonstrated that Hhcy was more closely linked to small 
      vessel occlusive disease and white matter hyperintensities (WMH) in general and 
      elderly population. Studies on WMH and homocysteine in elderly subjects are rare, 
      and the results were inconsistent. Our study aimed to investigate the 
      relationship between the serum homocysteine (HCY) and the severity of WMH in 
      elderly lacunar stroke patients.Methods: Consecutive elderly (>/=60 years old) 
      lacunar infarction patients were recruited in this cross-sectional study. All 
      patients were divided into two groups according to periventricular WMH (PVWMH) 
      and deep WMH (DWMH) Fazekas scores. Patients with a Fazekas score (PVWMH or DWMH) 
      of 0, 1, 2 were in mild-moderate group and 3 were in severe group. Vascular risk 
      factors and clinical features were compared between these two groups. Multiple 
      logistic regression analysis was used to determine the relationship between 
      severity of WMH and vascular risk factors.Results: A total of 587 participants 
      aged 60-95 years were enrolled. Patients with severe PVWMH (n = 178) had higher 
      age (p = 0.030) and higher incidence of stroke history (p<0.001) than those in 
      mild-moderate group. The level of serum HCY was significantly higher in patients 
      with severe PVWMH (p ＝ 0.002). Patients with severe DWMH (n = 142) had higher age 
      (p<0.001) and often had a history of stroke (p<0.001). The level of HCY was 
      higher in patients with severe degree of DWMH, but had no significance (p ＝ 
      0.153). Multivariable logistic regression analyses showed Hhcy were independently 
      associated with severe PVWMH after adjusted for age and vascular risk factors (p 
      ＝ 0.014).Conclusions: Hhcy was independently associated with severe PVWMH of 
      elderly lacunar stroke patients, but not DWMH.
FAU - Yu, Ling
AU  - Yu L
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing, P.R. China.
FAU - Yang, Lei
AU  - Yang L
AD  - Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, P.R. China.
FAU - Li, Yue
AU  - Li Y
AD  - Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, P.R. China.
FAU - Yang, Shuna
AU  - Yang S
AD  - Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, P.R. China.
FAU - Gu, Hua
AU  - Gu H
AD  - Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, P.R. China.
FAU - Hu, Wenli
AU  - Hu W
AD  - Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, P.R. China.
FAU - Gao, Shan
AU  - Gao S
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20191220
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/epidemiology
MH  - Leukoaraiosis/diagnostic imaging/epidemiology/*pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Stroke, Lacunar/diagnostic imaging/epidemiology/*pathology
OTO - NOTNLM
OT  - white matter hyperintensities (WMH)
OT  - Hyperhomocysteinemia
OT  - lacunar infarction
EDAT- 2019/11/21 06:00
MHDA- 2020/11/03 06:00
CRDT- 2019/11/21 06:00
PHST- 2019/11/21 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
PHST- 2019/11/21 06:00 [entrez]
AID - 10.1080/00207454.2019.1667795 [doi]
PST - ppublish
SO  - Int J Neurosci. 2020 Mar;130(3):231-236. doi: 10.1080/00207454.2019.1667795. Epub 
      2019 Dec 20.