PMID- 31744760
OWN - NLM
STAT- MEDLINE
DCOM- 20200617
LR  - 20200617
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 185
DP  - 2020 Jan 1
TI  - Cardio protective role of wogonin loaded nanoparticle against isoproterenol 
      induced myocardial infarction by moderating oxidative stress and inflammation.
PG  - 110635
LID - S0927-7765(19)30779-9 [pii]
LID - 10.1016/j.colsurfb.2019.110635 [doi]
AB  - Wogonin, one of the main active ingredients of Scutellaria radix, is a kind of 
      flavonoid compound. In the present study, we report that wogonin nanoparticles 
      (Wog np) protect Isoproterenol (ISO) induced Myocardial Infarction (MI) rats. 
      Nanoparticles of sizes less than 200 nm with spherical shape were prepared using 
      Polylactic-co-glycolic acid (PLGA) and Polyvinyl alcohol (PVA) respectively as 
      polymer and stabilizer. Male Wistar rats were divided into 4 groups. Group 1 as a 
      control group administered with physiological saline solution with 0.5 % 
      carboxymethylcellulose (1 mL/day). Group 2 served as toxic group; rats received 
      physiological saline solution with 0.5 % carboxymethylcellulose (1 mL/day) orally 
      for 21 days Groups 3 and 4 received Wog np (25 and 50 mg/kg/day) orally for 21 
      days and on the 20th and 21 st days group 2, 3, and 4 were administered with ISO 
      (85 mg/kg) through s.c. route at 24 h interval. pre-treatment with Wog np (25 and 
      50 mg/kg) could significantly reduce the cardiac infarct size, serum cardiac 
      markers, lipid peroxidation product (MDA) and inflammatory markers as well as 
      markedly upregulated the protein expression of nuclear factor erythroid 2-related 
      factor (Nrf2)and heme oxygenase-1 (HO-1) to confer its strong cardioprotective 
      activity against ISO induced myocardial damage.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Bei, Wan
AU  - Bei W
AD  - Department of Cardiology, Central Hospital of Wuhan, Affiliated to Huazhong 
      University of Science and Technology, Hubei Province, 4320000, China.
FAU - Jing, Li
AU  - Jing L
AD  - Department of Cardiology, Central Hospital of Wuhan, Affiliated to Huazhong 
      University of Science and Technology, Hubei Province, 4320000, China.
FAU - Chen, Nie
AU  - Chen N
AD  - Department of Cardiology, Central Hospital of Wuhan, Affiliated to Huazhong 
      University of Science and Technology, Hubei Province, 4320000, China. Electronic 
      address: niecheng86410@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20191110
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Flavanones)
RN  - 0 (Inflammation Mediators)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Oxidants)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - L628TT009W (Isoproterenol)
RN  - POK93PO28W (wogonin)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Biomarkers/blood
MH  - Cardiotonic Agents/pharmacology/*therapeutic use
MH  - Cytokines/metabolism
MH  - Drug Liberation
MH  - Flavanones/pharmacology/*therapeutic use
MH  - Heme Oxygenase-1/metabolism
MH  - Inflammation/*pathology
MH  - Inflammation Mediators/metabolism
MH  - Isoproterenol
MH  - Male
MH  - Myocardial Infarction/blood/*drug therapy/pathology
MH  - Myocardium/pathology
MH  - NF-E2-Related Factor 2/metabolism
MH  - Nanoparticles/*chemistry/ultrastructure
MH  - Oxidants/toxicity
MH  - Oxidative Stress/*drug effects
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Anti-inflammatory
OT  - Isoproterenol
OT  - Myocardial infraction
OT  - Oxidative stress
OT  - Wog np
EDAT- 2019/11/21 06:00
MHDA- 2020/06/18 06:00
CRDT- 2019/11/21 06:00
PHST- 2019/10/12 00:00 [received]
PHST- 2019/11/07 00:00 [revised]
PHST- 2019/11/09 00:00 [accepted]
PHST- 2019/11/21 06:00 [pubmed]
PHST- 2020/06/18 06:00 [medline]
PHST- 2019/11/21 06:00 [entrez]
AID - S0927-7765(19)30779-9 [pii]
AID - 10.1016/j.colsurfb.2019.110635 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2020 Jan 1;185:110635. doi: 
      10.1016/j.colsurfb.2019.110635. Epub 2019 Nov 10.