PMID- 31745553
OWN - NLM
STAT- MEDLINE
DCOM- 20210209
LR  - 20210209
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 105
IP  - 5
DP  - 2020 May 1
TI  - Metrics of Diabetes Risk Are Only Minimally Improved by Exercise Training in 
      Postmenopausal Breast Cancer Survivors.
LID - dgz213 [pii]
LID - 10.1210/clinem/dgz213 [doi]
AB  - CONTEXT: Insulin resistance is a risk factor for breast cancer recurrence. How 
      exercise training changes fasting and postglucose insulin resistance in breast 
      cancer survivors is unknown. OBJECTIVE: To evaluate exercise-induced changes in 
      postglucose ingestion insulin concentrations, insulin resistance, and their 
      associations with cancer-relevant biomarkers in breast cancer survivors. SETTING: 
      The University of Massachusetts Kinesiology Department. PARTICIPANTS: 15 
      postmenopausal breast cancer survivors not meeting the physical activity 
      guidelines (150 min/week of exercise). INTERVENTION: A supervised 12-week aerobic 
      exercise program (60 min/day, 3-4 days/week). MAIN OUTCOME MEASURES: Postglucose 
      ingestion insulin was determined by peak insulin and area under the insulin curve 
      (iAUC) during a 5-sample oral glucose tolerance test. Insulin sensitivity was 
      estimated from the Matsuda composite insulin sensitivity index (C-ISI). Changes 
      in fitness and body composition were determined from submaximal VO2peak and dual 
      energy X-ray absorptiometry. RESULTS: Participants averaged 156.8 +/- 16.6 min/week 
      of supervised exercise. Estimated VO2peak significantly increased (+2.8 +/- 1.4 
      mL/kg/min, P < .05) and body weight significantly decreased (-1.1 +/- 0.8 kg, P < 
      .05) following the intervention. There were no differences in fasting insulin, 
      iAUC, C-ISI, or peak insulin following the intervention. Insulin was only 
      significantly lower 120 min following glucose consumption (68.8 +/- 34.5 vs 56.2 +/- 
      31.9 uU/mL, P < .05), and there was a significant interaction with past/present 
      aromatase inhibitor (AI) use for peak insulin (-11.99 non-AI vs +13.91 AI uU/mL) 
      and iAUC (-24.03 non-AI vs +32.73 AI uU/mL). CONCLUSIONS: Exercise training had 
      limited overall benefits on insulin concentrations following glucose ingestion in 
      breast cancer survivors but was strongly influenced by AI use.
CI  - (c) Endocrine Society 2019. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Viskochil, Richard
AU  - Viskochil R
AD  - Department of Kinesiology, University of Massachusetts, Amherst, MA, US.
AD  - Huntsman Cancer Institute, Salt Lake City, UT, US.
FAU - Blankenship, Jennifer M
AU  - Blankenship JM
AD  - Department of Kinesiology, University of Massachusetts, Amherst, MA, US.
AD  - Anschutz Medical Center, Denver CO, US.
FAU - Makari-Judson, Grace
AU  - Makari-Judson G
AD  - Division of Hematology-Oncology, Baystate Medical Center, Springfield, MA, US.
FAU - Staudenmayer, John
AU  - Staudenmayer J
AD  - Department of Mathematics and Statistics, University of Massachusetts, Amherst, 
      MA, US.
FAU - Freedson, Patty S
AU  - Freedson PS
AD  - Department of Kinesiology, University of Massachusetts, Amherst, MA, US.
FAU - Hankinson, Susan E
AU  - Hankinson SE
AD  - Department of Biostatistics and Epidemiology, University of Massachusetts, 
      Amherst MA, US.
FAU - Braun, Barry
AU  - Braun B
AD  - Department of Kinesiology, University of Massachusetts, Amherst, MA, US.
AD  - Department of Health and Exercise Science, Colorado State University, Ft. 
      Collins, CO, US.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*rehabilitation
MH  - *Cancer Survivors
MH  - Diabetes Mellitus/*prevention & control
MH  - Exercise/*physiology
MH  - Exercise Therapy/methods
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance/physiology
MH  - Massachusetts
MH  - Middle Aged
MH  - *Postmenopause/blood/metabolism
MH  - Risk Factors
MH  - Risk Reduction Behavior
MH  - Treatment Outcome
OTO - NOTNLM
OT  - aromatase inhibitors
OT  - hyperinsulinemia
OT  - insulin resistance
EDAT- 2019/11/21 06:00
MHDA- 2021/02/10 06:00
CRDT- 2019/11/21 06:00
PHST- 2019/06/04 00:00 [received]
PHST- 2019/11/18 00:00 [accepted]
PHST- 2019/11/21 06:00 [pubmed]
PHST- 2021/02/10 06:00 [medline]
PHST- 2019/11/21 06:00 [entrez]
AID - 5634043 [pii]
AID - 10.1210/clinem/dgz213 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2020 May 1;105(5):dgz213. doi: 10.1210/clinem/dgz213.