PMID- 31746330
OWN - NLM
STAT- MEDLINE
DCOM- 20201218
LR  - 20201218
IS  - 1945-239X (Electronic)
IS  - 0021-9665 (Linking)
VI  - 58
IP  - 2
DP  - 2020 Jan 23
TI  - Differential Constituents in Roots, Stems and Leaves of Polygonum multiflorum 
      Thunb. Screened by UPLC/ESI-Q-TOF-MS and Multivariate Statistical Analysis.
PG  - 136-143
LID - 10.1093/chromsci/bmz086 [doi]
AB  - The differential constituents in leaves, stems and roots of Polygonum multiflorum 
      Thunb. were analyzed by ultra-performance liquid chromatography coupled with 
      electrospray ionization quadrupole time-of-flight mass spectrometry 
      (UPLC/ESI-Q-TOF-MS) and by multivariate statistical analysis. The established 
      extraction and analysis method showed relative standard deviations (RSDs) for 
      intra-day precision of less than 3.40%, for repeatability of less than 4.06% and 
      for stability of less than 5.10%. Principal component analysis and orthogonal 
      projections to latent structures discriminant analysis of the UPLC/ESI-Q-TOF-MS 
      data showed good ability to classify the leaves, stems and roots of P. 
      multiflorum Thunb. The differential constituents, such as stilbenes, 
      polygoacetophenoside, flavonoids and anthraquinones, accounting for variations 
      between the leaves, stems and roots, were filtered through the variable 
      importance in projection values and were further identified by elemental 
      composition analysis, mass fragmentation data and retention times of available 
      standards. Differences between the chemical compositions in the leaves, stems and 
      roots of P. multiflorum Thunb. were closely related to their various therapeutic 
      effects. This UPLC/ESI-Q-TOF-MS-based analytical strategy could be further 
      utilized to evaluate the overall quality of traditional Chinese medicines and 
      their differences of chemical constituents in different parts of the plant and/or 
      in the plants of different geographical locations.
CI  - (c) The Author(s) 2019. Published by Oxford University Press. All rights reserved. 
      For Permissions, please email: journals.permissions@oup.com.
FAU - Rui, Wen
AU  - Rui W
AD  - The Center for Drug Research and Development, Guangdong Pharmaceutical 
      University, Guangzhou 510006, P. R. China.
AD  - Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 
      510010, P. R. China.
AD  - School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, 
      P. R. China.
FAU - Xia, Wanxia
AU  - Xia W
AD  - Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 
      510010, P. R. China.
AD  - School of Bioscience and Bioengineering, South China University of Technology, 
      Guangzhou 510006, P. R. China.
FAU - Zhao, Wei
AU  - Zhao W
AD  - Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 
      510010, P. R. China.
AD  - School of Bioscience and Bioengineering, South China University of Technology, 
      Guangzhou 510006, P. R. China.
FAU - Li, Bingling
AU  - Li B
AD  - Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 
      510010, P. R. China.
FAU - Li, Jian
AU  - Li J
AD  - Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 
      510010, P. R. China.
FAU - Feng, Yifan
AU  - Feng Y
AD  - The Center for Drug Research and Development, Guangdong Pharmaceutical 
      University, Guangzhou 510006, P. R. China.
FAU - Chen, Hongyuan
AU  - Chen H
AD  - School of Basic Course, Guangdong Pharmaceutical University, Guangzhou 510006, P. 
      R. China.
FAU - Zhao, Shujin
AU  - Zhao S
AD  - Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 
      510010, P. R. China.
AD  - School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, 
      P. R. China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Chromatogr Sci
JT  - Journal of chromatographic science
JID - 0173225
RN  - 0 (Anthraquinones)
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Anthraquinones/chemistry
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Drugs, Chinese Herbal/*chemistry
MH  - Fallopia multiflora/*chemistry
MH  - Multivariate Analysis
MH  - Plant Leaves/chemistry
MH  - Plant Roots/chemistry
MH  - Spectrometry, Mass, Electrospray Ionization/methods
MH  - Tandem Mass Spectrometry/*methods
EDAT- 2019/11/21 06:00
MHDA- 2020/12/19 06:00
CRDT- 2019/11/21 06:00
PHST- 2017/07/30 00:00 [received]
PHST- 2019/01/19 00:00 [revised]
PHST- 2019/09/18 00:00 [accepted]
PHST- 2019/11/21 06:00 [pubmed]
PHST- 2020/12/19 06:00 [medline]
PHST- 2019/11/21 06:00 [entrez]
AID - 5627748 [pii]
AID - 10.1093/chromsci/bmz086 [doi]
PST - ppublish
SO  - J Chromatogr Sci. 2020 Jan 23;58(2):136-143. doi: 10.1093/chromsci/bmz086.