PMID- 31747056
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 130
IP  - 12
DP  - 2020 Dec
TI  - Diffusion Kurtosis Imaging and Intravoxel Incoherent Motion in Differentiating 
      Nasal Malignancies.
PG  - E727-E735
LID - 10.1002/lary.28424 [doi]
AB  - OBJECTIVES/HYPOTHESIS: To evaluate the usefulness of diffusion kurtosis imaging 
      (DKI) and intravoxel incoherent motion (IVIM) in the differentiation of sinonasal 
      malignant tumors (SNMTs) with different histological types. STUDY DESIGN: 
      Retrospective observational and diagnostic study. METHODS: Sixty-five patients 
      with SNMTs who underwent DKI and IVIM were enrolled in this retrospective study, 
      including 27 squamous cell carcinomas (SCCs), 13 olfactory neuroblastomas (ONBs), 
      14 malignant melanomas (MMs) and 11 lymphomas. The kurtosis (K) and diffusion 
      coefficient (Dk) from DKI and the pure diffusion coefficient (D), pseudodiffusion 
      coefficient (D*), perfusion fraction (f), and the product of D* and f (f∙D*) from 
      IVIM were measured. Kruskal-Wallis and Dunn multiple comparison tests with 
      Bonferroni correction, receiver operating characteristic curve, and logistic 
      regression analyses were used for statistical analysis. RESULTS: Lymphomas 
      demonstrated the highest K values but lowest Dk, D, D*, f, and f∙D* values among 
      these four malignant tumors. ONBs exhibited high K values and MMs had highest D*, 
      f, and f∙D* values. The cutoff value of </=0.887 x 10(-3) mm(2) /sec for f∙D* 
      provided a sensitivity, specificity, and an accuracy of 100%, 98.1%, and 98.5%, 
      respectively, for differentiating lymphomas from the other three entities. The 
      combination of f∙D* and D values showed a sensitivity of 92.9% and a specificity 
      of 92.5% for the discrimination of MMs from ONBs and SCCs. The K value was useful 
      for differentiating ONBs from SCCs, with a threshold value of 0.942 (sensitivity, 
      84.6%; specificity, 63.0%). CONCLUSIONS: The combined use of DKI and IVIM is 
      helpful for differentiating among four histological types of SNMTs. LEVEL OF 
      EVIDENCE: 3 Laryngoscope, 2019.
CI  - (c) 2019 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Xiao, Zebin
AU  - Xiao Z
AUID- ORCID: 0000-0002-3311-7403
AD  - Department of Radiology, Eye and Ear, Nose, and Throat Hospital of Shanghai 
      Medical School, Fudan University, Shanghai, China.
FAU - Tang, Zuohua
AU  - Tang Z
AUID- ORCID: 0000-0003-4687-5905
AD  - Department of Radiology, Eye and Ear, Nose, and Throat Hospital of Shanghai 
      Medical School, Fudan University, Shanghai, China.
FAU - Zheng, Chunquan
AU  - Zheng C
AD  - Department of Otolaryngology, Eye and Ear, Nose, and Throat Hospital of Shanghai 
      Medical School, Fudan University, Shanghai, China.
FAU - Luo, Jianfeng
AU  - Luo J
AD  - Department of Biostatistics, School of Public Health, Fudan University, Shanghai, 
      China.
FAU - Zhao, Keqing
AU  - Zhao K
AD  - Department of Otolaryngology, Eye and Ear, Nose, and Throat Hospital of Shanghai 
      Medical School, Fudan University, Shanghai, China.
FAU - Zhang, Zhongshuai
AU  - Zhang Z
AD  - Department of Diagnostic Imaging, Siemens Healthcare Ltd., Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20191120
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Diagnosis, Differential
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nose Neoplasms/*diagnostic imaging
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Histopathology
OT  - diffusion magnetic resonance imaging
OT  - magnetic resonance imaging
OT  - neoplasms
OT  - prognosis
EDAT- 2019/11/21 06:00
MHDA- 2021/01/12 06:00
CRDT- 2019/11/21 06:00
PHST- 2019/07/12 00:00 [received]
PHST- 2019/09/22 00:00 [revised]
PHST- 2019/10/26 00:00 [accepted]
PHST- 2019/11/21 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2019/11/21 06:00 [entrez]
AID - 10.1002/lary.28424 [doi]
PST - ppublish
SO  - Laryngoscope. 2020 Dec;130(12):E727-E735. doi: 10.1002/lary.28424. Epub 2019 Nov 
      20.