PMID- 31747377 OWN - NLM STAT- MEDLINE DCOM- 20200908 LR - 20211204 IS - 2191-0286 (Electronic) IS - 0792-6855 (Linking) VI - 31 IP - 3 DP - 2019 Nov 20 TI - Vietnamese coriander inhibits cell proliferation, survival and migration via suppression of Akt/mTOR pathway in oral squamous cell carcinoma. LID - /j/jbcpp.2020.31.issue-3/jbcpp-2019-0162/jbcpp-2019-0162.xml [pii] LID - 10.1515/jbcpp-2019-0162 [doi] AB - Background According to GLOBOCAN 2018, oral cancer was reported as the second highest cancer prevalent in India. Despite the several therapies available for oral cancer treatment, tumor recurrence and distant metastasis persist. This study investigates the anticancer potential of Persicaria odorata, commonly known as Vietnamese coriander, used widely in traditional systems of medicine for the treatment of inflammation, stomach ailments, tumors, etc. Methods The crude methanolic extract of P. odorata (MPo) was prepared. The anticancer properties of MPo on SAS cells and other human oral squamous cell carcinoma cell line were evaluated using in vitro experimental conditions. The phytochemical constituents present in the MPo were also determined. Results Persicaria odorata possesses antiproliferative, antisurvival, antimetastatic activities, and induced cell cycle arrest in the G2 phase. It inhibited Akt-mammalian target of rapamycin (mTOR) signaling pathway and also downregulated the expression of essential proteins that are involved in tumorigenesis such as cyclin D1, cyclooxygenase 2 (COX2), survivin, matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor-A (VEGF-A). Moreover, the presence of flavonoids and quinones also revealed the anticancer activity of the plant. Conclusion Overall, our study concludes that P. odorata exhibits its anticancer properties through the downregulation of Akt/mTOR signaling pathway in a dose-dependent manner. FAU - Devi Khwairakpam, Amrita AU - Devi Khwairakpam A AD - Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam-781039, India. FAU - Monisha, Javadi AU - Monisha J AD - Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam-781039, India. FAU - Roy, Nand Kishor AU - Roy NK AD - Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam-781039, India. FAU - Bordoloi, Devivasha AU - Bordoloi D AD - Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam-781039, India. FAU - Padmavathi, Ganesan AU - Padmavathi G AD - Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam-781039, India. FAU - Banik, Kishore AU - Banik K AD - Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam-781039, India. FAU - Khatoon, Elina AU - Khatoon E AD - Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam-781039, India. FAU - Kunnumakkara, Ajaikumar B AU - Kunnumakkara AB AD - Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam-781039, India, Phone: +91 361 258 2231 (Office), +91 789 600 5326 (Mobile), Fax:+91 361 258 2249 (Office). LA - eng PT - Journal Article DEP - 20191120 PL - Germany TA - J Basic Clin Physiol Pharmacol JT - Journal of basic and clinical physiology and pharmacology JID - 9101750 RN - 0 (Plant Extracts) RN - EC 2.7.1.1 (MTOR protein, human) RN - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) RN - EC 2.7.11.1 (TOR Serine-Threonine Kinases) SB - IM MH - Carcinoma, Squamous Cell/*drug therapy MH - Cell Cycle Checkpoints/drug effects MH - Cell Line, Tumor MH - Cell Movement/*drug effects MH - Cell Proliferation/*drug effects MH - Cell Survival/*drug effects MH - Coriandrum/*chemistry MH - G2 Phase/drug effects MH - Humans MH - India MH - Mouth Neoplasms/*drug therapy MH - Plant Extracts/pharmacology MH - Proto-Oncogene Proteins c-akt/*metabolism MH - Signal Transduction/drug effects MH - TOR Serine-Threonine Kinases/*metabolism MH - Vietnam OTO - NOTNLM OT - Persicaria odorata OT - Akt OT - Vietnamese coriander OT - anticancer OT - mTOR OT - oral cancer EDAT- 2019/11/21 06:00 MHDA- 2020/09/09 06:00 CRDT- 2019/11/21 06:00 PHST- 2019/06/06 00:00 [received] PHST- 2019/08/31 00:00 [accepted] PHST- 2019/11/21 06:00 [pubmed] PHST- 2020/09/09 06:00 [medline] PHST- 2019/11/21 06:00 [entrez] AID - /j/jbcpp.ahead-of-print/jbcpp-2019-0162/jbcpp-2019-0162.xml [pii] AID - 10.1515/jbcpp-2019-0162 [doi] PST - epublish SO - J Basic Clin Physiol Pharmacol. 2019 Nov 20;31(3):/j/jbcpp.2020.31.issue-3/jbcpp-2019-0162/jbcpp-2019-0162.xml. doi: 10.1515/jbcpp-2019-0162.