PMID- 31747406
OWN - NLM
STAT- MEDLINE
DCOM- 20200402
LR  - 20200402
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 11
DP  - 2019
TI  - Association of clinical factors with survival outcomes in laryngeal squamous cell 
      carcinoma (LSCC).
PG  - e0224665
LID - 10.1371/journal.pone.0224665 [doi]
LID - e0224665
AB  - AIM: Treatment strategies in laryngeal squamous cell cancer (LSCC) straddle the 
      need for long term survival and tumor control as well as preservation of 
      laryngeal function as far as possible. We sought to identify prognostic factors 
      affecting LSCC outcomes in our population. METHODS: Clinical characteristics, 
      treatments and survival outcomes of patients with LSCC were analysed. Baseline 
      comorbidity data was collected and age-adjusted Charlson Comorbidity Index (aCCI) 
      was calculated. Outcomes of overall survival (OS), progression-free survival 
      (PFS) and laryngectomy-free survival (LFS) were evaluated. RESULTS: Two hundred 
      and fifteen patients were included, 170 (79%) underwent primary radiation/ 
      chemoradiation and the remainder upfront surgery with adjuvant therapy where 
      indicated. The majority of patients were male, Chinese and current/ex-smokers. 
      Presence of comorbidity was common with median aCCI of 3. Median OS was 5.8 
      years. On multivariable analyses, high aCCI and advanced nodal status were 
      associated with inferior OS (HR 1.24 per one point increase in aCCI, P<0.001 and 
      HR 3.52; p<0.001 respectively), inferior PFS (HR 1.14; p = 0.007 and HR 3.23; 
      p<0.001 respectively) and poorer LFS (HR 1.19; p = 0.001 and HR 2.95; p<0.001 
      respectively). Higher tumor (T) stage was associated with inferior OS and LFS (HR 
      1.61; p = 0.02 and HR 1.91; p = 0.01 respectively). CONCLUSION: In our Asian 
      population, the presence of comorbidities and high nodal status were associated 
      with inferior OS, PFS and LFS whilst high T stage was associated with inferior 
      LFS and OS.
FAU - Fong, Pei Yuan
AU  - Fong PY
AD  - Division of Medical Oncology, National Cancer Centre, Singapore.
FAU - Tan, Sze Huey
AU  - Tan SH
AD  - Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, 
      Singapore.
FAU - Lim, Darren Wan Teck
AU  - Lim DWT
AD  - Division of Medical Oncology, National Cancer Centre, Singapore.
FAU - Tan, Eng Huat
AU  - Tan EH
AD  - Division of Medical Oncology, National Cancer Centre, Singapore.
FAU - Ng, Quan Sing
AU  - Ng QS
AD  - Division of Medical Oncology, National Cancer Centre, Singapore.
FAU - Sommat, Kiattisa
AU  - Sommat K
AD  - Division of Radiation Oncology, National Cancer Centre, Singapore.
FAU - Tan, Daniel Shao Weng
AU  - Tan DSW
AD  - Division of Medical Oncology, National Cancer Centre, Singapore.
FAU - Ang, Mei Kim
AU  - Ang MK
AUID- ORCID: 0000-0003-3209-864X
AD  - Division of Medical Oncology, National Cancer Centre, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20191120
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Chemoradiotherapy, Adjuvant/statistics & numerical data
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*mortality/pathology/therapy
MH  - Laryngectomy/*statistics & numerical data
MH  - Larynx/pathology/radiation effects/surgery
MH  - Lymphatic Metastasis/pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Neoadjuvant Therapy/statistics & numerical data
MH  - Neoplasm Staging
MH  - Organ Sparing Treatments/*statistics & numerical data
MH  - Prognosis
MH  - Progression-Free Survival
MH  - Retrospective Studies
MH  - Singapore/epidemiology
MH  - Squamous Cell Carcinoma of Head and Neck/*mortality/pathology/therapy
PMC - PMC6867599
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/11/21 06:00
MHDA- 2020/04/03 06:00
PMCR- 2019/11/20
CRDT- 2019/11/21 06:00
PHST- 2019/07/19 00:00 [received]
PHST- 2019/10/18 00:00 [accepted]
PHST- 2019/11/21 06:00 [entrez]
PHST- 2019/11/21 06:00 [pubmed]
PHST- 2020/04/03 06:00 [medline]
PHST- 2019/11/20 00:00 [pmc-release]
AID - PONE-D-19-20376 [pii]
AID - 10.1371/journal.pone.0224665 [doi]
PST - epublish
SO  - PLoS One. 2019 Nov 20;14(11):e0224665. doi: 10.1371/journal.pone.0224665. 
      eCollection 2019.