PMID- 31747493
OWN - NLM
STAT- MEDLINE
DCOM- 20191125
LR  - 20200108
IS  - 0869-2084 (Print)
IS  - 0869-2084 (Linking)
VI  - 64
IP  - 11
DP  - 2019
TI  - [Immunological markers of defeat of nervous tissue as an element of predictive 
      model of damage of nervous system at syphilis.].
PG  - 659-662
LID - 10.18821/0869-2084-2019-64-11-659-662 [doi]
AB  - To develop predictive model of damage of nervous system on the basis of 
      definition of concentration of interleukins-23, 12p40 and also a glial fibrillar 
      acid protein (GFAP) in liquor of patients with various forms of syphilis. 
      Comprehensive laboratory examination of patients with neurosyphilis and syphilis 
      without specific damage of nervous system who were observed in venereologic 
      office of BOUZAS of OO <<Clinical Dermatovenerologic Clinic>> of Omsk is conducted. 
      To all patients were carried out: a serological blood analysis, serological and 
      clinical trial of liquor, and also immunological research of liquor (interleukins 
      - 23, 12p40, and also GFAP). On the basis of the research IL-23, SILT-12p40, 
      GFAP, the level of protein and a pleocytosis in liquor the predictive model of 
      development of neurosyphilis in patients with syphilis without specific damage of 
      nervous system is offered. The analysis of immunological changes in liquor of 
      patients showed that the research of a number of cytokines and markers of damage 
      of nervous tissue to liquor as the most specific and reliable, especially in the 
      absence of clinical symptomatology from central nervous system can be an integral 
      part of diagnostics of neurosyphilis also.
FAU - Novikov, Y A
AU  - Novikov YA
AUID- ORCID: 0000-0003-0230-6380
AD  - Department of a dermatovenereology and cosmetology <<Omsk state medical 
      university>>, 644001, Omsk, Russia.
FAU - Indutny, A V
AU  - Indutny AV
AUID- ORCID: 0000-0003-1951-5824
AD  - Department of clinical laboratory diagnostics <<Omsk state medical university>>, 
      644001, Omsk, Russia.
FAU - Kravchenko, E N
AU  - Kravchenko EN
AUID- ORCID: 0000-0001-8625-8237
AD  - Clinical dermatovenerologic clinic, 644001, Omsk, Russia.
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Klin Lab Diagn
JT  - Klinicheskaia laboratornaia diagnostika
JID - 9432021
RN  - 0 (GFAP protein, human)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Interleukin-12 Subunit p40)
RN  - 0 (Interleukin-23)
SB  - IM
MH  - Glial Fibrillary Acidic Protein/*blood
MH  - Humans
MH  - Interleukin-12 Subunit p40/*blood
MH  - Interleukin-23/*blood
MH  - Nerve Tissue/*pathology
MH  - Neurosyphilis/*diagnosis/immunology
OTO - NOTNLM
OT  - GFAP
OT  - interleukin 12p40
OT  - interleukin 23
OT  - liquor
OT  - neurosyphilis
OT  - predictive model
OT  - syphilis
COIS- The authors declare no conflict of interest.
EDAT- 2019/11/21 06:00
MHDA- 2019/11/26 06:00
CRDT- 2019/11/21 06:00
PHST- 2019/10/10 00:00 [received]
PHST- 2019/10/14 00:00 [accepted]
PHST- 2019/11/21 06:00 [entrez]
PHST- 2019/11/21 06:00 [pubmed]
PHST- 2019/11/26 06:00 [medline]
AID - 10.18821/0869-2084-2019-64-11-659-662 [doi]
PST - ppublish
SO  - Klin Lab Diagn. 2019;64(11):659-662. doi: 10.18821/0869-2084-2019-64-11-659-662.