PMID- 31747574
OWN - NLM
STAT- MEDLINE
DCOM- 20201223
LR  - 20201223
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 150
DP  - 2020 May 1
TI  - pH-Activated surface charge-reversal double-crosslinked hyaluronic acid nanogels 
      with feather keratin as multifunctional crosslinker for tumor-targeting DOX 
      delivery.
PG  - 1104-1112
LID - S0141-8130(19)33446-4 [pii]
LID - 10.1016/j.ijbiomac.2019.10.116 [doi]
AB  - Feather keratin (FK) was used as a multifunctional crosslinker for the 
      fabrication of both pH responsive ionically and reduction responsive covalently 
      crosslinked hyaluronic acid (HA) nanogels, as pH-activated surface 
      charge-reversal double-crosslinked protein/polysaccharide complex nanocarriers 
      for the tumor-targeting DOX delivery. The effect of the preparation condition on 
      the diameter and the drug-loading capacity of the resultant drug delivery systems 
      (DDSs) were investigated in detail. The in vitro controlled release profiles 
      indicated the pH/reduction dual-responsive sustained release of DOX from the 
      proposed double-crosslinked DOX@C-FK/HA nanogels. The in vitro experiments 
      demonstrated that the DOX@C-FK/HA nanogels could be internalized into the HCT 116 
      cells via a CD44-receptor-mediated endocytosis pathway, exhibiting an enhanced 
      anti-tumor efficacy than the free DOX.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Zhang, Huifang
AU  - Zhang H
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China.
FAU - Pei, Mingliang
AU  - Pei M
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China.
FAU - Liu, Peng
AU  - Liu P
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China. Electronic address: pliu@lzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191117
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Gels)
RN  - 68238-35-7 (Keratins)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Cross-Linking Reagents/*chemistry
MH  - Delayed-Action Preparations/chemistry/pharmacokinetics/pharmacology
MH  - Doxorubicin/chemistry/pharmacokinetics/pharmacology
MH  - Feathers/*chemistry
MH  - Gels
MH  - HCT116 Cells
MH  - Hep G2 Cells
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Keratins/*chemistry
MH  - *Nanoparticles/chemistry/therapeutic use
MH  - Neoplasms/*drug therapy/metabolism/pathology
OTO - NOTNLM
OT  - Complex nanogels
OT  - Double-crosslinked
OT  - Drug delivery system
OT  - Tumor-targeting
OT  - pH-activated surface charge-reversal
OT  - pH/reduction dual-responsive sustained release
EDAT- 2019/11/21 06:00
MHDA- 2020/12/29 06:00
CRDT- 2019/11/21 06:00
PHST- 2019/05/09 00:00 [received]
PHST- 2019/09/29 00:00 [revised]
PHST- 2019/10/12 00:00 [accepted]
PHST- 2019/11/21 06:00 [pubmed]
PHST- 2020/12/29 06:00 [medline]
PHST- 2019/11/21 06:00 [entrez]
AID - S0141-8130(19)33446-4 [pii]
AID - 10.1016/j.ijbiomac.2019.10.116 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2020 May 1;150:1104-1112. doi: 
      10.1016/j.ijbiomac.2019.10.116. Epub 2019 Nov 17.