PMID- 31747662
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20200413
IS  - 1662-4033 (Electronic)
IS  - 1662-4025 (Print)
IS  - 1662-4025 (Linking)
VI  - 12
IP  - 6
DP  - 2019
TI  - Long-Term Weight Loss and Metabolic Syndrome Remission after Bariatric Surgery: 
      The Effect of Sex, Age, Metabolic Parameters and Surgical Technique - A 4-Year 
      Follow-Up Study.
PG  - 639-652
LID - 10.1159/000503753 [doi]
AB  - INTRODUCTION: Bariatric surgery is an effective treatment for morbid obesity and 
      its metabolic related comorbidities. However, the literature reports inconsistent 
      results regarding weight loss (WL) and the resolution of comorbidities associated 
      with obesity. OBJECTIVE: We aim to evaluate long-term differences in WL between 
      different surgical techniques and the impact of each surgical technique on 
      metabolic parameters (type 2 diabetes mellitus [T2DM], dyslipidemia,hypertension, 
      and metabolic syndrome). We also aim to evaluate the effect of baseline clinical 
      characteristics in WL and in the evolution of metabolic syndrome (MetS) 
      components. Our hypothesis is that different types of surgery have different 
      effects on WL and the prevalence of comorbidities over time. METHODS: We 
      retrospectively evaluated WL and metabolic parameter remission (T2DM, 
      dyslipidemia, hypertension, and MetS) during 4 years in 1,837 morbidly obese 
      patients (females, 85%; age, 42.5 +/- 10.6 years; BMI, 44.0 +/- 5.8) who underwent 
      bariatric surgery (Roux-en-Y gastric bypass [RYGB], laparoscopic sleeve 
      gastrectomy [LSG], and laparoscopic adjustable gastric band [LAGB]). RESULTS: The 
      mean percentage of WL for RYGB, LSG, and LAGB was, respectively, 32.9 +/- 8.7, 29.8 
      +/- 9.8, and 16.2 +/- 9.6 at 12 months and 30.6 +/- 9.1, 22.7 +/- 10.0, and 15.8 +/- 10.8 
      at 48 months (p < 0.001), even after adjustment for baseline weight, BMI, age, 
      and sex (p < 0.001). Women had more WL during the first 36 months (p = 0.013 and 
      0.007 at 12 and 36 months, respectively) and older patients had less WL compared 
      to younger ones (p <0.001), except at 48 months. Patients with T2DM had less WL 
      than those without diabetes after adjustment (sex, age, and surgical technique) 
      during the same period. Patients with hypertension had less WL at 12 months (p = 
      0.009) and MetS at 24 months (p = 0.020) compared to those without these 
      comorbidities. There was no significant difference regarding the presence of 
      dyslipidemia in WL. The RYGB group showed better results for MetS resolution. 
      CONCLUSION: During the 4-year follow-up, RYGB was the surgical procedure that 
      caused the highest WL and MetS resolution.
CI  - (c) 2019 The Author(s) Published by S. Karger AG, Basel.
FAU - Guerreiro, Vanessa
AU  - Guerreiro V
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal, vanessa.a.guerreiro@gmail.com.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal, 
      vanessa.a.guerreiro@gmail.com.
FAU - Neves, Joao Sergio
AU  - Neves JS
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Salazar, Daniela
AU  - Salazar D
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Ferreira, Maria Joao
AU  - Ferreira MJ
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Oliveira, Sofia Castro
AU  - Oliveira SC
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Souteiro, Pedro
AU  - Souteiro P
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Pedro, Jorge
AU  - Pedro J
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Magalhaes, Daniela
AU  - Magalhaes D
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Varela, Ana
AU  - Varela A
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Belo, Sandra
AU  - Belo S
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Freitas, Paula
AU  - Freitas P
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
AD  - Instituto de Investigacao e Inovacao em Saude, University of Porto, Porto, 
      Portugal.
AD  - Multidisciplinary Group for Surgical Management of Obesity, Centro Hospitalar Sao 
      Joao, Porto, Portugal.
FAU - Carvalho, Davide
AU  - Carvalho D
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Sao Joao, 
      Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, Porto, Portugal.
CN  - AMTCO Group
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20191120
PL  - Switzerland
TA  - Obes Facts
JT  - Obesity facts
JID - 101469429
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - *Bariatric Surgery/methods/statistics & numerical data
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/complications/epidemiology/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Gastrectomy/methods/statistics & numerical data
MH  - Gastric Bypass/methods/statistics & numerical data
MH  - Humans
MH  - Laparoscopy/methods/statistics & numerical data
MH  - Male
MH  - Metabolic Syndrome/complications/*epidemiology/*surgery
MH  - Middle Aged
MH  - Obesity, Morbid/complications/*epidemiology/*surgery
MH  - Remission Induction
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Treatment Outcome
MH  - Weight Loss/*physiology
PMC - PMC6940448
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Metabolic syndrome
OT  - Morbid obesity
OT  - Weight loss
COIS- The authors declare that they have no conflict of interests.
EDAT- 2019/11/21 06:00
MHDA- 2020/04/14 06:00
PMCR- 2019/11/20
CRDT- 2019/11/21 06:00
PHST- 2019/04/24 00:00 [received]
PHST- 2019/09/26 00:00 [accepted]
PHST- 2019/11/21 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2019/11/21 06:00 [entrez]
PHST- 2019/11/20 00:00 [pmc-release]
AID - 000503753 [pii]
AID - ofa-0012-0639 [pii]
AID - 10.1159/000503753 [doi]
PST - ppublish
SO  - Obes Facts. 2019;12(6):639-652. doi: 10.1159/000503753. Epub 2019 Nov 20.