PMID- 31747683
OWN - NLM
STAT- MEDLINE
DCOM- 20200131
LR  - 20200131
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 60
IP  - 14
DP  - 2019 Nov 1
TI  - Subretinal Drusenoid Deposits in the Elderly in a Population-Based Study (the 
      Montrachet Study).
PG  - 4838-4848
LID - 10.1167/iovs.19-27283 [doi]
AB  - PURPOSE: The aim of this study was to investigate the prevalence of subretinal 
      drusenoid deposits (SDD) and to identify associated factors in an elderly 
      population. METHODS: The participants of the population-based Montrachet study 
      underwent an exhaustive ophthalmologic examination, including color fundus 
      photography and macular spectral domain-optical coherence tomography (SD-OCT), 
      coupled with infrared reflectance imaging. The presence of SDD and other 
      age-related macular degeneration lesions, according to the European Eye 
      Epidemiology SD-OCT classification of macular diseases, and subfoveal choroidal 
      thickness were recorded. Moreover, the association of SDD and both clinical and 
      demographic factors as well as plasma levels of vitamin E and lutein/zeaxanthin 
      (L/Z) were analyzed. RESULTS: The mean age of patients was 82.3 +/- 3.8 years and 
      62.7% were female. The prevalence of SDD was 18.1% (n = 205) in the subjects with 
      at least one eye interpretable (n = 1135). In multivariate analysis, SDD was 
      positively associated with increasing age (OR, 4.6; 95% CI, 2.8-7.7; P < 0.001 
      for subjects aged >85 years), female sex (OR, 1.7; 95% CI, 1.2-2.4; P = 0.005), 
      and plasma L/Z level (OR, 1.2; 95% CI, 1.0-1.5; P = 0.039), and negatively 
      associated with lipid-lowering drugs use (OR, 0.5; 95% CI, 0.3-0.9; P = 0.014 for 
      statin medications) and subfoveal choroidal thickness (OR, 0.8; 95% CI, 0.7-0.9; 
      P = 0.002). CONCLUSIONS: The prevalence of SDD was high in subjects older than 75 
      years, more frequent in women, and was associated with a thinner choroid. The 
      association with lipid-lowering drugs deserves further investigation.
FAU - Gabrielle, Pierre-Henry
AU  - Gabrielle PH
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
AD  - Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, Burgundy 
      University, Dijon, France.
FAU - Seydou, Alassane
AU  - Seydou A
AD  - Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, Burgundy 
      University, Dijon, France.
AD  - Department of Epidemiology, INSERM unit, University Hospital, Dijon, France.
FAU - Arnould, Louis
AU  - Arnould L
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
FAU - Acar, Niyazi
AU  - Acar N
AD  - Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, Burgundy 
      University, Dijon, France.
FAU - Devilliers, Herve
AU  - Devilliers H
AD  - Department of Epidemiology, INSERM unit, University Hospital, Dijon, France.
FAU - Baudin, Florian
AU  - Baudin F
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
FAU - Ben Ghezala, Ines
AU  - Ben Ghezala I
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
FAU - Binquet, Christine
AU  - Binquet C
AD  - Department of Epidemiology, INSERM unit, University Hospital, Dijon, France.
FAU - Bron, Alain Marie
AU  - Bron AM
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
AD  - Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, Burgundy 
      University, Dijon, France.
FAU - Creuzot-Garcher, Catherine
AU  - Creuzot-Garcher C
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
AD  - Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, Burgundy 
      University, Dijon, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Zeaxanthins)
RN  - 1406-18-4 (Vitamin E)
RN  - X72A60C9MT (Lutein)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Lutein/blood
MH  - Male
MH  - Photography
MH  - Prevalence
MH  - Retinal Drusen/blood/*diagnosis/*epidemiology
MH  - Sex Factors
MH  - Tomography, Optical Coherence
MH  - Vitamin E/blood
MH  - Zeaxanthins/blood
EDAT- 2019/11/21 06:00
MHDA- 2020/02/01 06:00
CRDT- 2019/11/21 06:00
PHST- 2019/11/21 06:00 [entrez]
PHST- 2019/11/21 06:00 [pubmed]
PHST- 2020/02/01 06:00 [medline]
AID - 2756022 [pii]
AID - 10.1167/iovs.19-27283 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4838-4848. doi: 
      10.1167/iovs.19-27283.