PMID- 31750757
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20201121
IS  - 1938-2022 (Electronic)
IS  - 1938-2014 (Print)
IS  - 1938-2014 (Linking)
VI  - 11
IP  - 6
DP  - 2019
TI  - Curcumin protects islet cells from glucolipotoxicity by inhibiting oxidative 
      stress and NADPH oxidase activity both in vitro and in vivo.
PG  - 152-164
LID - 10.1080/19382014.2019.1690944 [doi]
AB  - Curcumin possesses medicinal properties that are beneficial in various diseases, 
      such as heart disease, cancer, and type 2 diabetes mellitus (T2 DM). It has been 
      proposed that pancreatic beta cell dysfunction in T2 DM is promoted by oxidative 
      stress caused by NADPH oxidase over-activity. The aim of the present study was to 
      evaluate the efficacy of curcumin as a protective agent against high 
      glucose/palmitate (HP)-induced islet cell damage and in streptozotocin 
      (STZ)-induced DM rats. INS-1 cells were exposed to HP with or without curcumin. 
      Cell proliferation, islet cell morphological changes, reactive oxygen species 
      production, superoxide dismutase and catalase activity, insulin levels, NADPH 
      oxidase subunit expression, and the expression of apoptotic factors by INS-1 
      cells were observed. Our results show that curcumin can effectively inhibit the 
      impairment of cell proliferation and activated oxidative stress, increase insulin 
      levels, and reduce the high expression of NADPH oxidase subunits and apoptotic 
      factors induced by HP in INS-1 cells. The STZ-induced DM rat model was also used 
      to determine whether curcumin can protect islets in vivo. Our results show that 
      curcumin significantly reduced pathological damage and increased insulin levels 
      of islets in STZ-induced DM rats. Curcumin also successfully inhibited the high 
      expression of NADPH oxidase subunits and apoptotic factors in STZ-induced DM 
      rats. These results suggest that curcumin is able to attenuate HP-induced 
      oxidative stress in islet cells and protect these cells from apoptosis by 
      modulating the NADPH pathway. In view of its efficiency, curcumin has potential 
      for translation applications in protecting islets from glucolipotoxicity.
FAU - Li, Jing
AU  - Li J
AD  - Hubei Key Laboratory of Cardiovascular, Cerebrovascular, and Metabolic Disorders, 
      Hubei University of Science and Technology, Xianning, Hubei, P. R. China.
FAU - Wu, Ninghua
AU  - Wu N
AD  - Hubei Key Laboratory of Cardiovascular, Cerebrovascular, and Metabolic Disorders, 
      Hubei University of Science and Technology, Xianning, Hubei, P. R. China.
FAU - Chen, Xiao
AU  - Chen X
AD  - Hubei Key Laboratory of Cardiovascular, Cerebrovascular, and Metabolic Disorders, 
      Hubei University of Science and Technology, Xianning, Hubei, P. R. China.
FAU - Chen, Hongguang
AU  - Chen H
AD  - Hubei Key Laboratory of Cardiovascular, Cerebrovascular, and Metabolic Disorders, 
      Hubei University of Science and Technology, Xianning, Hubei, P. R. China.
FAU - Yang, Xiaosong
AU  - Yang X
AD  - Hubei Key Laboratory of Cardiovascular, Cerebrovascular, and Metabolic Disorders, 
      Hubei University of Science and Technology, Xianning, Hubei, P. R. China.
FAU - Liu, Chao
AU  - Liu C
AD  - Hubei Key Laboratory of Cardiovascular, Cerebrovascular, and Metabolic Disorders, 
      Hubei University of Science and Technology, Xianning, Hubei, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191121
PL  - United States
TA  - Islets
JT  - Islets
JID - 101495366
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Insulin)
RN  - 0 (Protective Agents)
RN  - EC 1.6.3.- (NADPH Oxidases)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Cell Proliferation/drug effects
MH  - Curcumin/*pharmacology
MH  - Diabetes Mellitus, Experimental/*metabolism
MH  - Disease Models, Animal
MH  - Enzyme Inhibitors/pharmacology
MH  - Insulin/metabolism
MH  - Islets of Langerhans/*metabolism
MH  - NADPH Oxidases/*metabolism
MH  - Oxidative Stress/drug effects
MH  - Protective Agents/pharmacology
MH  - Rats
PMC - PMC6930025
OTO - NOTNLM
OT  - Curcumin
OT  - NADPH oxidases
OT  - diabetes mellitus
OT  - glucolipotoxicty
OT  - islet
OT  - oxidative stress
EDAT- 2019/11/22 06:00
MHDA- 2020/05/19 06:00
PMCR- 2020/11/21
CRDT- 2019/11/22 06:00
PHST- 2019/11/22 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2019/11/22 06:00 [entrez]
PHST- 2020/11/21 00:00 [pmc-release]
AID - 1690944 [pii]
AID - 10.1080/19382014.2019.1690944 [doi]
PST - ppublish
SO  - Islets. 2019;11(6):152-164. doi: 10.1080/19382014.2019.1690944. Epub 2019 Nov 21.