PMID- 31751180
OWN - NLM
STAT- MEDLINE
DCOM- 20210414
LR  - 20240422
IS  - 1522-1601 (Electronic)
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 128
IP  - 1
DP  - 2020 Jan 1
TI  - Effects of aging and lifelong aerobic exercise on basal and exercise-induced 
      inflammation.
PG  - 87-99
LID - 10.1152/japplphysiol.00495.2019 [doi]
AB  - Age-associated chronic basal inflammation compromises muscle mass and 
      adaptability, but exercise training may exert an anti-inflammatory effect. This 
      investigation assessed basal and exercise-induced inflammation in three cohorts 
      of men: young exercisers [YE; n = 10 men; 25 +/- 1 yr; maximal oxygen consumption 
      (V̇o(2max)), 53 +/- 3 mL.kg(-1).min(-1); quadriceps area, 78 +/- 3 cm(2); 
      means +/- SE], old healthy nonexercisers (OH; n = 10; 75 +/- 1 yr; V̇o(2max), 22 +/- 1 
      mL.kg(-1).min(-1); quadriceps area, 56 +/- 3 cm(2)), and lifelong exercisers with 
      an aerobic training history of 53 +/- 1 yr (LLE; n = 21; 74 +/- 1 yr; V̇o(2max), 
      34 +/- 1 mL.kg(-1).min(-1); quadriceps area, 67 +/- 2 cm(2)). Resting serum IL-6, 
      TNF-alpha, C-reactive protein, and IGF-1 levels were measured. Vastus lateralis 
      muscle biopsies were obtained at rest (basal) and 4 h after an acute exercise 
      challenge (3 x 10 repetitions, 70% 1-repetition maximum) to assess gene 
      expression of cytokines [IL-6, TNF-alpha, IL-1beta, IL-10, IL-4, interleukin-1 receptor 
      antagonist (IL-1Ra), and transforming growth factor-beta (TGF-beta)], chemokines [IL-8 
      and monocyte chemoattractant protein-1 (MCP-1)], cyclooxygenase enzymes 
      [cyclooxygenase-1 and -2 (COX-1 and COX-2, respectively), prostaglandin E(2) 
      synthases [microsomal prostaglandin E synthase 1 (mPGES-1) and cytosolic 
      prostaglandin E(2) synthase (cPGES)] and receptors [prostaglandin E(2) receptor 
      EP3 and EP4 subtypes (EP3 and EP4, respectively), and macrophage markers [cluster 
      of differentiation 16b (CD16b) and CD163], as well as basal macrophage abundance 
      (CD68(+) cells). Aging led to higher (P </= 0.05) circulating IL-6 and skeletal 
      muscle COX-1, mPGES-1, and CD163 expression. However, LLE had significantly lower 
      serum IL-6 levels (P </= 0.05 vs. OH) and a predominantly anti-inflammatory muscle 
      profile [higher IL-10 (P </= 0.05 vs. YE), TNF-alpha, TGF-beta, and EP4 levels (P </= 0.05 
      vs. OH)]. In OH only, acute exercise increased expression of proinflammatory 
      factors TNF-alpha, TGF-beta, and IL-8 (P </= 0.05). LLE had postexercise gene expression 
      similar to YE, except lower IL-10 (P </= 0.10), mPGES-1, and EP3 expression (P </= 
      0.05). Thus, although aging led to a proinflammatory profile within blood and 
      muscle, lifelong exercise partially prevented this and generally preserved the 
      acute inflammatory response to exercise seen in young exercising men. Lifelong 
      exercise may positively impact muscle health throughout aging by promoting 
      anti-inflammation in skeletal muscle.NEW & NOTEWORTHY This study assessed a 
      unique population of lifelong aerobic exercising men and demonstrated that their 
      activity status exerts an anti-inflammatory effect in skeletal muscle and 
      circulation. Furthermore, we provide evidence that the inflammatory response to 
      acute exercise is dysregulated by aging but preserved with lifelong exercise, 
      which might improve skeletal muscle resilience to unaccustomed loading and 
      adaptability into late life.
FAU - Lavin, Kaleen M
AU  - Lavin KM
AD  - Human Performance Laboratory, Ball State University, Muncie, Indiana.
FAU - Perkins, Ryan K
AU  - Perkins RK
AD  - Human Performance Laboratory, Ball State University, Muncie, Indiana.
FAU - Jemiolo, Bozena
AU  - Jemiolo B
AD  - Human Performance Laboratory, Ball State University, Muncie, Indiana.
FAU - Raue, Ulrika
AU  - Raue U
AD  - Human Performance Laboratory, Ball State University, Muncie, Indiana.
FAU - Trappe, Scott W
AU  - Trappe SW
AD  - Human Performance Laboratory, Ball State University, Muncie, Indiana.
FAU - Trappe, Todd A
AU  - Trappe TA
AD  - Human Performance Laboratory, Ball State University, Muncie, Indiana.
LA  - eng
GR  - R01 AG038576/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20191121
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*metabolism/pathology
MH  - Case-Control Studies
MH  - Cytokines/genetics/*metabolism
MH  - *Exercise
MH  - Female
MH  - Gene Expression Profiling
MH  - Humans
MH  - Inflammation/genetics/metabolism/pathology/*prevention & control
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*metabolism
MH  - Oxygen Consumption
PMC - PMC6985808
OTO - NOTNLM
OT  - acute exercise
OT  - inflammaging
OT  - inflammation
OT  - lifelong exercise
OT  - skeletal muscle
COIS- No conflicts of interest, financial or otherwise, are declared by the authors.
EDAT- 2019/11/22 06:00
MHDA- 2021/04/15 06:00
PMCR- 2021/01/01
CRDT- 2019/11/22 06:00
PHST- 2019/11/22 06:00 [pubmed]
PHST- 2021/04/15 06:00 [medline]
PHST- 2019/11/22 06:00 [entrez]
PHST- 2021/01/01 00:00 [pmc-release]
AID - JAPPL-00495-2019 [pii]
AID - 10.1152/japplphysiol.00495.2019 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2020 Jan 1;128(1):87-99. doi: 
      10.1152/japplphysiol.00495.2019. Epub 2019 Nov 21.