PMID- 31751351
OWN - NLM
STAT- MEDLINE
DCOM- 20200218
LR  - 20211204
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Print)
IS  - 1935-2727 (Linking)
VI  - 13
IP  - 11
DP  - 2019 Nov
TI  - Association of IL18 genetic polymorphisms with Chagas disease in Latin American 
      populations.
PG  - e0007859
LID - 10.1371/journal.pntd.0007859 [doi]
LID - e0007859
AB  - Host genetic factors have been suggested to play an important role in the 
      susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) 
      in the development of the disease, in the present study, we analyzed three IL18 
      genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to 
      Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy 
      (CCC), in different Latin America populations. Genetic data of 3,608 patients 
      from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate 
      previous findings with increased statistical power. Seropositive and seronegative 
      individuals were compared for T. cruzi infection susceptibility. In the Colombian 
      cohort, the allelic frequencies of the three variants showed a significant 
      association, with adjustment for sex and age, and also after applying multiple 
      testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed 
      a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni 
      correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an 
      association with protection from cardiomyopathy in the Colombian cohort (OR: 
      0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after 
      applying multiple testing adjustments. The meta-analysis of the CCC vs. 
      asymptomatic patients from the four cohorts showed no evidence of association. In 
      conclusion, our results validated the association found previously in the 
      Colombian cohort suggesting that IL18 rs360719 plays an important role in the 
      susceptibility to T. cruzi infection and no evidence of association was found 
      between the IL18 genetic variants and CCC in the Latin American population 
      studied.
FAU - Strauss, Mariana
AU  - Strauss M
AUID- ORCID: 0000-0003-4558-1294
AD  - Centro de Estudios e Investigacion de la Enfermedad de Chagas y Leishmaniasis, 
      FCM, INICSA-CONICET-UNC, Cordoba, Argentina.
FAU - Acosta-Herrera, Marialbert
AU  - Acosta-Herrera M
AD  - Instituto de Parasitologia y Biomedicina Lopez-Neyra, IPBLN-CSIC, PTS Granada, 
      Granada, Espana.
FAU - Alcaraz, Alexia
AU  - Alcaraz A
AD  - Instituto de Parasitologia y Biomedicina Lopez-Neyra, IPBLN-CSIC, PTS Granada, 
      Granada, Espana.
FAU - Casares-Marfil, Desire
AU  - Casares-Marfil D
AD  - Instituto de Parasitologia y Biomedicina Lopez-Neyra, IPBLN-CSIC, PTS Granada, 
      Granada, Espana.
FAU - Bosch-Nicolau, Pau
AU  - Bosch-Nicolau P
AD  - Unidad de Medicina Tropical y Salud Internacional Hospital Universitari Vall 
      d'Hebron, PROSICS, Barcelona, Espana.
FAU - Lo Presti, Maria Silvina
AU  - Lo Presti MS
AUID- ORCID: 0000-0002-6151-5230
AD  - Centro de Estudios e Investigacion de la Enfermedad de Chagas y Leishmaniasis, 
      FCM, INICSA-CONICET-UNC, Cordoba, Argentina.
FAU - Molina, Israel
AU  - Molina I
AD  - Unidad de Medicina Tropical y Salud Internacional Hospital Universitari Vall 
      d'Hebron, PROSICS, Barcelona, Espana.
FAU - Gonzalez, Clara Isabel
AU  - Gonzalez CI
AD  - GIEM, Universidad Industrial de Santander, Bucaramanga, Colombia.
CN  - Chagas Genetics CYTED Network
FAU - Martin, Javier
AU  - Martin J
AD  - Instituto de Parasitologia y Biomedicina Lopez-Neyra, IPBLN-CSIC, PTS Granada, 
      Granada, Espana.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20191121
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Argentina
MH  - Bolivia
MH  - Brazil
MH  - Chagas Disease/*genetics/parasitology
MH  - Cohort Studies
MH  - Colombia
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Hispanic or Latino/genetics
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Latin America
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Trypanosoma cruzi/physiology
MH  - Young Adult
PMC - PMC6894881
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/11/22 06:00
MHDA- 2020/02/19 06:00
PMCR- 2019/11/21
CRDT- 2019/11/22 06:00
PHST- 2019/07/10 00:00 [received]
PHST- 2019/10/21 00:00 [accepted]
PHST- 2019/12/05 00:00 [revised]
PHST- 2019/11/22 06:00 [pubmed]
PHST- 2020/02/19 06:00 [medline]
PHST- 2019/11/22 06:00 [entrez]
PHST- 2019/11/21 00:00 [pmc-release]
AID - PNTD-D-19-01126 [pii]
AID - 10.1371/journal.pntd.0007859 [doi]
PST - epublish
SO  - PLoS Negl Trop Dis. 2019 Nov 21;13(11):e0007859. doi: 
      10.1371/journal.pntd.0007859. eCollection 2019 Nov.