PMID- 31751663
OWN - NLM
STAT- MEDLINE
DCOM- 20210201
LR  - 20210201
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 129
DP  - 2020 Jan
TI  - The "Metabolic biomarkers of frailty in older people with type 2 diabetes 
      mellitus" (MetaboFrail) study: Rationale, design and methods.
PG  - 110782
LID - S0531-5565(19)30710-7 [pii]
LID - 10.1016/j.exger.2019.110782 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a leading cause of disability globally. 
      Frailty is a high-impact geriatric condition that increases the risk of negative 
      health outcomes and imposes remarkable health and social burden. Both frailty and 
      T2DM show multifaceted pathophysiology, phenotypic heterogeneity, and fluctuating 
      manifestations that challenge their management, especially when the two 
      conditions co-occur. Muscle wasting and its correlates (e.g., metabolic 
      perturbations and functional decline) that underlie frailty may exacerbates 
      clinical manifestations of T2DM in older people, resulting in worse prognosis. 
      The intrinsic complexity of frailty and T2DM has hampered the identification of 
      clinically meaningful biomarkers to track the clinical progression of the two 
      conditions over time and to monitor the efficacy of pharmacological and lifestyle 
      interventions. Here, we propose an innovative approach for biomarker 
      identification that couples multi-platform analytical determinations with 
      chemometric modeling strategies. This novel multi-marker discovery process is 
      described in the context of the "Metabolic biomarkers of frailty in older people 
      with type 2 diabetes mellitus" (MetaboFrail) study that aimed at identifying 
      metabolic biomarkers of frailty in functionally limited older persons with T2DM.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Calvani, Riccardo
AU  - Calvani R
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico 
      Universitario "Agostino Gemelli" IRCCS, Rome, Italy.
FAU - Rodriguez-Manas, Leocadio
AU  - Rodriguez-Manas L
AD  - Servicio de Geriatria, Hospital Universitario de Getafe, Madrid, Spain.
FAU - Picca, Anna
AU  - Picca A
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico 
      Universitario "Agostino Gemelli" IRCCS, Rome, Italy.
FAU - Marini, Federico
AU  - Marini F
AD  - Department of Chemistry, Sapienza Universita di Roma, Rome, Italy.
FAU - Biancolillo, Alessandra
AU  - Biancolillo A
AD  - Department of Physical and Chemical Sciences, University of L'Aquila, Italy.
FAU - Laosa, Olga
AU  - Laosa O
AD  - Foundation for Biomedical Research, Hospital Universitario de Getafe, Madrid, 
      Spain.
FAU - Pedraza, Laura
AU  - Pedraza L
AD  - Foundation for Biomedical Research, Hospital Universitario de Getafe, Madrid, 
      Spain.
FAU - Gervasoni, Jacopo
AU  - Gervasoni J
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico 
      Universitario "Agostino Gemelli" IRCCS, Rome, Italy.
FAU - Primiano, Aniello
AU  - Primiano A
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico 
      Universitario "Agostino Gemelli" IRCCS, Rome, Italy.
FAU - Miccheli, Alfredo
AU  - Miccheli A
AD  - Department of Chemistry, Sapienza Universita di Roma, Rome, Italy.
FAU - Bourdel-Marchasson, Isabelle
AU  - Bourdel-Marchasson I
AD  - Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
FAU - Regueme, Sophie C
AU  - Regueme SC
AD  - Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
FAU - Bernabei, Roberto
AU  - Bernabei R
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico 
      Universitario "Agostino Gemelli" IRCCS, Rome, Italy.
FAU - Marzetti, Emanuele
AU  - Marzetti E
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico 
      Universitario "Agostino Gemelli" IRCCS, Rome, Italy. Electronic address: 
      emanuele.marzetti@policlinicogemelli.it.
FAU - Sinclair, Alan J
AU  - Sinclair AJ
AD  - Foundation for Diabetes Research in Older People, Diabetes Frail Ltd., Luton, UK.
FAU - Gambassi, Giovanni
AU  - Gambassi G
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico 
      Universitario "Agostino Gemelli" IRCCS, Rome, Italy.
CN  - European MID-Frail Consortium
LA  - eng
PT  - Clinical Trial Protocol
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191118
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - *Frail Elderly
MH  - Frailty/*metabolism
MH  - Humans
MH  - Sarcopenia/metabolism
OTO - NOTNLM
OT  - Chemometrics
OT  - Metabolic profiling
OT  - Metabolomics
OT  - Multivariate analysis
OT  - Personalized medicine
OT  - Sarcopenia
EDAT- 2019/11/22 06:00
MHDA- 2021/02/02 06:00
CRDT- 2019/11/22 06:00
PHST- 2019/10/15 00:00 [received]
PHST- 2019/11/14 00:00 [accepted]
PHST- 2019/11/22 06:00 [pubmed]
PHST- 2021/02/02 06:00 [medline]
PHST- 2019/11/22 06:00 [entrez]
AID - S0531-5565(19)30710-7 [pii]
AID - 10.1016/j.exger.2019.110782 [doi]
PST - ppublish
SO  - Exp Gerontol. 2020 Jan;129:110782. doi: 10.1016/j.exger.2019.110782. Epub 2019 
      Nov 18.