PMID- 31751796
OWN - NLM
STAT- MEDLINE
DCOM- 20200819
LR  - 20200819
IS  - 1873-4162 (Electronic)
IS  - 1344-6223 (Linking)
VI  - 42
DP  - 2020 Feb
TI  - A case of intoxication with a new cathinone derivative alpha-PiHP - A presentation of 
      concentrations in biological specimens.
PG  - 101626
LID - S1344-6223(19)30293-7 [pii]
LID - 10.1016/j.legalmed.2019.101626 [doi]
AB  - INTRODUCTION: Cathinones are currently the second largest and the second most 
      frequently seized group of new psychoactive substances (NPS). One of the most 
      recent synthetic cathinones that has appeared on the 'legal highs' market is 
      alpha-pyrrolidinoisohexanophenone (alpha-PiHP). CASE HISTORY: An 18-year-old man was 
      found dead in an apartment. The autopsy materials were collected for 
      toxicological analyses. METHODS: The quantitative analyses were carried out by 
      LC-MS/MS. RESULTS: alpha-PiHP was detected and quantified in all post-mortem 
      materials except the hair. The determined concentrations of the compound in the 
      blood, urine and bile were 69 ng/mL, 2072 ng/mL, and 341 ng/mL respectively. The 
      concentrations of alpha-PiHP in solid tissues were in the range of 7-478 ng/g. 
      4-Chloromethcathinone (4-CMC), N-ethylhexedrone, benzoylecgonine and 
      3,4-methylenedioxymethamphetamine (MDMA) were also detected in some materials. 
      DISCUSSION: No cases presenting concentrations of alpha-PiHP in biological materials 
      have been reported so far. Due to the similarity of structures and the reported 
      dosages, an attempt to compare the concentrations of alpha-PVP and alpha-PHP has been 
      made. In the described case, functional death through intoxication of alpha-PiHP was 
      accepted as the final cause of death. The other detected substances did not 
      contribute to death due to their very likely distant administration. CONCLUSION: 
      alpha-PiHP is another new synthetic cathinone that is a danger to the life of users. 
      The described fatal intoxication case presents the concentrations of alpha-PiHP in 
      post-mortem materials. This data could be valuable for further interpretation of 
      other results from toxicological analyses in cases where the use of alpha-PiHP is 
      suspected.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Adamowicz, Piotr
AU  - Adamowicz P
AD  - Institute of Forensic Research, Westerplatte 9, 31-033 Krakow, Poland. Electronic 
      address: padamowicz@ies.krakow.pl.
FAU - Jurczyk, Agnieszka
AU  - Jurczyk A
AD  - Department of Forensic Medicine, Medical University of Lodz, Sedziowska 18a, 
      91-304 Lodz, Poland.
FAU - Gil, Dominika
AU  - Gil D
AD  - Institute of Forensic Research, Westerplatte 9, 31-033 Krakow, Poland.
FAU - Szustowski, Szymon
AU  - Szustowski S
AD  - Lisciasta 74F/3, 91-357 Lodz, Poland.
LA  - eng
PT  - Journal Article
DEP - 20191112
PL  - Ireland
TA  - Leg Med (Tokyo)
JT  - Legal medicine (Tokyo, Japan)
JID - 100889186
RN  - 0 (Pyrrolidines)
RN  - 0 (alpha-pyrrolidinohexanophenone)
SB  - IM
MH  - Adolescent
MH  - Chromatography, Liquid/methods
MH  - *Forensic Medicine
MH  - Humans
MH  - Male
MH  - Pyrrolidines/analysis/*poisoning
MH  - Tandem Mass Spectrometry/methods
OTO - NOTNLM
OT  - Alpha-pyrrolidinoisohexanophenone
OT  - Biological material
OT  - Cathinone
OT  - Concentrations
OT  - Intoxication
OT  - alpha-PiHP
EDAT- 2019/11/22 06:00
MHDA- 2020/08/20 06:00
CRDT- 2019/11/22 06:00
PHST- 2019/06/18 00:00 [received]
PHST- 2019/09/21 00:00 [revised]
PHST- 2019/10/07 00:00 [accepted]
PHST- 2019/11/22 06:00 [pubmed]
PHST- 2020/08/20 06:00 [medline]
PHST- 2019/11/22 06:00 [entrez]
AID - S1344-6223(19)30293-7 [pii]
AID - 10.1016/j.legalmed.2019.101626 [doi]
PST - ppublish
SO  - Leg Med (Tokyo). 2020 Feb;42:101626. doi: 10.1016/j.legalmed.2019.101626. Epub 
      2019 Nov 12.