PMID- 31751821
OWN - NLM
STAT- MEDLINE
DCOM- 20200406
LR  - 20211204
IS  - 1876-4320 (Electronic)
IS  - 1874-9399 (Print)
IS  - 1874-9399 (Linking)
VI  - 1863
IP  - 4
DP  - 2020 Apr
TI  - Regulation of mTOR signaling by long non-coding RNA.
PG  - 194449
LID - S1874-9399(18)30452-8 [pii]
LID - 10.1016/j.bbagrm.2019.194449 [doi]
AB  - The mechanistic target of rapamycin (mTOR) is a major signaling hub that 
      coordinates cellular and organismal responses, such as cell growth, 
      proliferation, apoptosis, and metabolism. Dysregulation of mTOR signaling occurs 
      in many human diseases, and there are significant ongoing efforts to 
      pharmacologically target this pathway. Long noncoding RNAs (lncRNA), defined by a 
      length > 200 nucleotides and absence of a long open-reading-frame, are a class of 
      non-protein-coding RNAs. Mutations and dysregulations of lncRNAs are directly 
      linked to the development and progression of many diseases, including cancer, 
      diabetes, and neurologic disorders. Recent findings reveal diverse functions for 
      lncRNA that include transcriptional regulation, organization of nuclear domains, 
      and regulation of proteins or RNA molecules. Despite considerable development in 
      our understanding of lncRNA over the past decade, only a fraction of annotated 
      lncRNAs has been examined for biological function. In addition, lncRNAs have 
      emerged as therapeutic targets due to their ability to modulate multiple 
      pathways, including mTOR signaling. This review will provide an up-to-date 
      summary of lncRNAs that are involved in regulating mTOR pathway.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Aboudehen, Karam
AU  - Aboudehen K
AD  - Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, 
      USA. Electronic address: karam@umn.edu.
LA  - eng
GR  - K01 DK116934/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20191118
PL  - Netherlands
TA  - Biochim Biophys Acta Gene Regul Mech
JT  - Biochimica et biophysica acta. Gene regulatory mechanisms
JID - 101731723
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (RNA, Long Noncoding)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Humans
MH  - Oligonucleotides, Antisense
MH  - RNA, Long Noncoding/*metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC7125019
MID - NIHMS1544621
EDAT- 2019/11/22 06:00
MHDA- 2020/04/09 06:00
PMCR- 2021/04/01
CRDT- 2019/11/22 06:00
PHST- 2019/08/12 00:00 [received]
PHST- 2019/11/05 00:00 [revised]
PHST- 2019/11/08 00:00 [accepted]
PHST- 2019/11/22 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2019/11/22 06:00 [entrez]
PHST- 2021/04/01 00:00 [pmc-release]
AID - S1874-9399(18)30452-8 [pii]
AID - 10.1016/j.bbagrm.2019.194449 [doi]
PST - ppublish
SO  - Biochim Biophys Acta Gene Regul Mech. 2020 Apr;1863(4):194449. doi: 
      10.1016/j.bbagrm.2019.194449. Epub 2019 Nov 18.