PMID- 31754171
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Nov 21
TI  - Longitudinal morphological changes during recovery from brain deformation due to 
      idiopathic normal pressure hydrocephalus after ventriculoperitoneal shunt 
      surgery.
PG  - 17318
LID - 10.1038/s41598-019-53888-7 [doi]
LID - 17318
AB  - The present study aimed to examine time-dependent change in cerebrospinal fluid 
      distribution and various radiological indices for evaluating shunt effectiveness 
      in patients with idiopathic normal pressure hydrocephalus (iNPH). This study 
      included 54 patients with iNPH who underwent MRI before and after 
      ventriculoperitoneal shunt surgery. The volume of the total ventricles and 
      subarachnoid spaces decreased within 1 month after shunting. However, more than 1 
      year after shunting, the volume of the total ventricles decreased, whereas that 
      of the total subarachnoid spaces increased. Although cerebrospinal fluid 
      distribution changed considerably throughout the follow-up period, the brain 
      parenchyma expanded only 2% from the baseline brain volume within 1 month after 
      shunting and remained unchanged thereafter. The volume of the convexity 
      subarachnoid space markedly increased. The changing rate of convexity 
      subarachnoid space per ventricle ratio (CVR) was greater than that of any 
      two-dimensional index. The brain per ventricle ratio (BVR), callosal angle and 
      z-Evans index continued gradually changing, whereas Evans index did not change 
      throughout the follow-up period. Both decreased ventricular volume and increased 
      convexity subarachnoid space volume were important for evaluating shunt 
      effectiveness. Therefore, we recommend CVR and BVR as useful indices for the 
      diagnosis and evaluation of treatment response in patients with iNPH.
FAU - Yamada, Shigeki
AU  - Yamada S
AUID- ORCID: 0000-0001-7158-5569
AD  - Department of Neurosurgery, Shiga University of Medical Science, Shiga, Japan. 
      shigekiyamada39@gmail.com.
AD  - Department of Neurosurgery and Normal Pressure Hydrocephalus Center, Rakuwakai 
      Otowa Hospital, Kyoto, Japan. shigekiyamada39@gmail.com.
AD  - Interfaculty Initiative in Information Studies/Institute of Industrial Science, 
      The University of Tokyo, Tokyo, Japan. shigekiyamada39@gmail.com.
FAU - Ishikawa, Masatsune
AU  - Ishikawa M
AD  - Department of Neurosurgery and Normal Pressure Hydrocephalus Center, Rakuwakai 
      Otowa Hospital, Kyoto, Japan.
AD  - Rakuwa Villa Ilios, Kyoto, Japan.
FAU - Yamaguchi, Makoto
AU  - Yamaguchi M
AD  - Department of Neurosurgery and Normal Pressure Hydrocephalus Center, Rakuwakai 
      Otowa Hospital, Kyoto, Japan.
FAU - Yamamoto, Kazuo
AU  - Yamamoto K
AD  - Department of Neurosurgery and Normal Pressure Hydrocephalus Center, Rakuwakai 
      Otowa Hospital, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191121
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Aftercare/methods
MH  - Aged
MH  - Aged, 80 and over
MH  - Cerebral Ventricles/diagnostic imaging/*physiopathology
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Hydrocephalus, Normal Pressure/diagnosis/physiopathology/*surgery
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neuroimaging/*methods
MH  - Subarachnoid Space/diagnostic imaging/*physiopathology
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - *Ventriculoperitoneal Shunt
PMC - PMC6872815
COIS- Shigeki Yamada received speakers' honoraria from Integra, and Fujifilm Medical 
      Systems. Masatsune Ishikawa, Kazuo Yamamoto and Makoto Yamaguchi declare no 
      potential conflict of interest.
EDAT- 2019/11/23 06:00
MHDA- 2020/11/11 06:00
PMCR- 2019/11/21
CRDT- 2019/11/23 06:00
PHST- 2019/02/19 00:00 [received]
PHST- 2019/11/07 00:00 [accepted]
PHST- 2019/11/23 06:00 [entrez]
PHST- 2019/11/23 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2019/11/21 00:00 [pmc-release]
AID - 10.1038/s41598-019-53888-7 [pii]
AID - 53888 [pii]
AID - 10.1038/s41598-019-53888-7 [doi]
PST - epublish
SO  - Sci Rep. 2019 Nov 21;9(1):17318. doi: 10.1038/s41598-019-53888-7.