PMID- 31754217 OWN - NLM STAT- MEDLINE DCOM- 20201105 LR - 20231019 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 9 IP - 1 DP - 2019 Nov 21 TI - Reconfigurable Architecture for Multi-lead ECG Signal Compression with High-frequency Noise Reduction. PG - 17233 LID - 10.1038/s41598-019-53460-3 [doi] LID - 17233 AB - Electrocardiogram (ECG) is a record of the heart's electrical activity over a specified period, and it is the most popular noninvasive diagnostic test to identify several cardiac diseases. It is an integral part of a typical eHealth system, where the ECG signals are often needed to be compressed for long term data recording and remote transmission. Reconfigurable architecture offers high-speed parallel computation unit, particularly the Field Programmable Gate Array (FPGA) along with adaptable software features. Hence, this type of design is suitable for multi-channel signal processing units like ECGs, which usually require precise real-time computation. This paper presents a reconfigurable signal processing unit which is implemented in ZedBoard- a development board for Xilinx Zynq -7000 SoC. The compression algorithm is based on Fast Fourier Transformation. The implemented system can work in real-time and achieve a maximum 90% compression rate without any significant signal distortion (i.e., less than 9% normalized percentage of root-mean-square deviation). This compression rate is 5% higher than the state-of-the-art hardware implementation. Additionally, this algorithm has an inherent capability of high-frequency noise reduction, which makes it unique in this field. The confirmatory analysis is done using six databases from the PhysioNet databank to compare and validate the effectiveness of the proposed system. FAU - Chowdhury, Mehdi Hasan AU - Chowdhury MH AUID- ORCID: 0000-0002-7645-8443 AD - Department of EE, City University of Hong Kong, Kowloon, Hong Kong. chowdhury.ee@my.cityu.edu.hk. AD - Department of EEE, Chittagong University of Engineering & Technology, Chittagong, Bangladesh. chowdhury.ee@my.cityu.edu.hk. FAU - Cheung, Ray C C AU - Cheung RCC AD - Department of EE, City University of Hong Kong, Kowloon, Hong Kong. LA - eng PT - Journal Article DEP - 20191121 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Algorithms MH - Computers MH - Data Compression/*methods MH - Electrocardiography/*methods MH - Fourier Analysis MH - Signal Processing, Computer-Assisted MH - Software PMC - PMC6872821 COIS- The authors declare no competing interests. EDAT- 2019/11/23 06:00 MHDA- 2020/11/06 06:00 PMCR- 2019/11/21 CRDT- 2019/11/23 06:00 PHST- 2019/03/26 00:00 [received] PHST- 2019/10/28 00:00 [accepted] PHST- 2019/11/23 06:00 [entrez] PHST- 2019/11/23 06:00 [pubmed] PHST- 2020/11/06 06:00 [medline] PHST- 2019/11/21 00:00 [pmc-release] AID - 10.1038/s41598-019-53460-3 [pii] AID - 53460 [pii] AID - 10.1038/s41598-019-53460-3 [doi] PST - epublish SO - Sci Rep. 2019 Nov 21;9(1):17233. doi: 10.1038/s41598-019-53460-3.