PMID- 31754388
OWN - NLM
STAT- MEDLINE
DCOM- 20200828
LR  - 20200828
IS  - 1838-7640 (Electronic)
IS  - 1838-7640 (Linking)
VI  - 9
IP  - 26
DP  - 2019
TI  - The gut microbiota-inflammation-brain axis in end-stage renal disease: 
      perspectives from default mode network.
PG  - 8171-8181
LID - 10.7150/thno.35387 [doi]
AB  - The gut-brain axis in end-stage renal disease (ESRD) is attracting more and more 
      attention. However, the mechanism of gut-brain axis based cognitive disorders in 
      ESRD patients remains unclear. The purpose of this study was to investigate the 
      linkages between the gut microbiota, inflammatory cytokines, brain default mode 
      network (DMN) and cognitive function in ESRD patients. Methods: This prospective 
      study enrolled 28 ESRD patients (13 males and 15 females, mean age of 44 +/- 14 
      years) and 19 healthy controls (HCs) (12 males and 7 females, mean age of 44 +/- 10 
      years). All subjects underwent stool microbiota analysis, blood inflammatory 
      cytokines examination, brain MRI scans and cognitive assessments. Resting state 
      functional MRI (rs-fMRI) data were used to construct DMN and graph theory was 
      applied to characterize network topological properties. Two samples t-test was 
      applied for the comparisons between ESRD and HCs. Correlation analysis and 
      mediation analysis were conducted among factors with significant group 
      differences. Results: ESRD patients displayed gut microbiota alterations, 
      increased systemic inflammation and worse cognitive performance compared to HCs 
      (all p < 0.05). Graph analysis revealed disrupted DMN topological organization, 
      aberrant nodal centralities and functional connectivities (FCs) in ESRD patients 
      relative to HCs (all p < 0.05, FDR corrected). Significant correlations were 
      found between gut microbiota, inflammatory cytokines, DMN network measures and 
      cognitive assessments. Mediation analysis found that gut microbiota alteration 
      impaired DMN connectivity by increasing systemic inflammation. Conclusion: The 
      present study first revealed gut microbiota alterations, systemic inflammation, 
      DMN dissociation and cognitive dysfunction in ESRD patients simultaneously and 
      further illuminated their inner relationship.
CI  - (c) The author(s).
FAU - Wang, Yun Fei
AU  - Wang YF
AD  - Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical 
      School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, 
      Jiangsu Province, 210002, China.
FAU - Zheng, Li Juan
AU  - Zheng LJ
AD  - Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical 
      School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, 
      Jiangsu Province, 210002, China.
FAU - Liu, Ya
AU  - Liu Y
AD  - Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical 
      School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, 
      Jiangsu Province, 210002, China.
FAU - Ye, Yu Bing
AU  - Ye YB
AD  - Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical 
      School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, 
      Jiangsu Province, 210002, China.
FAU - Luo, Song
AU  - Luo S
AD  - Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical 
      School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, 
      Jiangsu Province, 210002, China.
FAU - Lu, Guang Ming
AU  - Lu GM
AD  - Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical 
      School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, 
      Jiangsu Province, 210002, China.
FAU - Gong, Dehua
AU  - Gong D
AD  - National Clinical Research Center of Kidney Disease, Jinling Hospital, Medical 
      School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, 
      Jiangsu Province, 210002, China.
FAU - Zhang, Long Jiang
AU  - Zhang LJ
AD  - Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical 
      School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, 
      Jiangsu Province, 210002, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191018
PL  - Australia
TA  - Theranostics
JT  - Theranostics
JID - 101552395
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Brain/*pathology
MH  - Brain Mapping
MH  - Cognitive Dysfunction/physiopathology
MH  - Cytokines/analysis
MH  - Female
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - Inflammation/physiopathology
MH  - *Kidney Failure, Chronic/microbiology/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
PMC - PMC6857049
OTO - NOTNLM
OT  - default mode network
OT  - end-stage renal disease
OT  - gut microbiota
OT  - inflammatory cytokine
OT  - resting state fMRI
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2019/11/23 06:00
MHDA- 2020/08/29 06:00
PMCR- 2019/01/01
CRDT- 2019/11/23 06:00
PHST- 2019/04/01 00:00 [received]
PHST- 2019/09/11 00:00 [accepted]
PHST- 2019/11/23 06:00 [entrez]
PHST- 2019/11/23 06:00 [pubmed]
PHST- 2020/08/29 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - thnov09p8171 [pii]
AID - 10.7150/thno.35387 [doi]
PST - epublish
SO  - Theranostics. 2019 Oct 18;9(26):8171-8181. doi: 10.7150/thno.35387. eCollection 
      2019.