PMID- 31755105
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20200914
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 91
IP  - 5
DP  - 2020 May
TI  - Aminobisphosphonate-treated ewes as a model of osteonecrosis of the jaw and of 
      dental implant failure.
PG  - 628-637
LID - 10.1002/JPER.19-0213 [doi]
AB  - BACKGROUND: Bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) and 
      dental implant failure are two negative side effects of chronic aminoBP 
      treatment. METHODS: Eleven ovariectomized (OVX) ewes and four ewes subjected to 
      sham surgery (SHAM) were treated as follows: OVX (n = 5): OVX plus saline 
      solution; zoledronic acid-treated group (ZOL) (n = 6): OVX plus ZOL; SHAM 
      (n = 4): SHAM plus saline solution. Extraction of the first upper molar was 
      performed at 1 year, dental implant placement at 2 years, and sacrifice at 28 
      months. RESULTS: Implants remained in place in SHAM and OVX ewes but were lost in 
      all ZOL ewes. ZOL sheep (2/6) showed inflammation and necrotic bone at mandibular 
      region. No differences in serum calcium (Ca), inorganic phosphate (Pi) or 
      25-hydroxyvitamin D were observed, whereas bone alkaline phosphatase levels 
      decreased in the three studied groups (P < 0.05). The significantly lowest levels 
      of carboxy-terminal telopeptide of type I collagen were observed in ZOL 
      (P < 0.05), and showed no differences between SHAM and OVX. OVX showed the lowest 
      and ZOL the highest Ca and Pi contents in femur and maxilla (P < 0.05). Bone 
      volume (BV/TV%) and iliac crest were similar at baseline and at month 4. At the 
      end of the study, BV/TV%, proximal femur and hemi-mandible bone mineral content 
      and bone mineral density, and trabeculae number were similar in SHAM and ZOL, and 
      lower in OVX (P < 0.05). CONCLUSION: All ZOL-treated ewes on a schedule similar 
      to that used in cancer patients showed extensive suppression of bone remodeling 
      and implant failure. Some of the ZOL ewes developed BRONJ.
CI  - (c) 2019 American Academy of Periodontology.
FAU - Davison, Mario R
AU  - Davison MR
AD  - School of Dentistry, Rio Negro National University, Rio Negro, Argentina.
FAU - Lyardet, Leonardo
AU  - Lyardet L
AD  - School of Dentistry, Rio Negro National University, Rio Negro, Argentina.
FAU - Preliasco, Mariana
AU  - Preliasco M
AD  - School of Dentistry, Rio Negro National University, Rio Negro, Argentina.
FAU - Yaful, Graciela
AU  - Yaful G
AD  - Veterinary Sciences, Rio Negro National University, Rio Negro, Argentina.
FAU - Torres, Perla
AU  - Torres P
AD  - Veterinary Sciences, Rio Negro National University, Rio Negro, Argentina.
FAU - Bonanno, Marina S
AU  - Bonanno MS
AD  - Metabolic Bone Diseases Laboratory, Immunology, Genetic and Metabolism Institute 
      (INIGEM), School of Pharmacy and Biochemistry, Clinical Hospital "Jose de San 
      Martin", National Council for Scientific and Technologic Research 
      (CONICET)/Buenos Aires University (UBA), Buenos Aires, Argentina.
FAU - Pellegrini, Gretel G
AU  - Pellegrini GG
AD  - Metabolic Bone Diseases Laboratory, Immunology, Genetic and Metabolism Institute 
      (INIGEM), School of Pharmacy and Biochemistry, Clinical Hospital "Jose de San 
      Martin", National Council for Scientific and Technologic Research 
      (CONICET)/Buenos Aires University (UBA), Buenos Aires, Argentina.
FAU - Zeni, Susana N
AU  - Zeni SN
AD  - Metabolic Bone Diseases Laboratory, Immunology, Genetic and Metabolism Institute 
      (INIGEM), School of Pharmacy and Biochemistry, Clinical Hospital "Jose de San 
      Martin", National Council for Scientific and Technologic Research 
      (CONICET)/Buenos Aires University (UBA), Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191215
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Dental Implants)
RN  - 0 (Diphosphonates)
RN  - 0 (Imidazoles)
SB  - IM
MH  - Animals
MH  - Bone Density
MH  - *Bone Density Conservation Agents
MH  - *Dental Implants
MH  - Diphosphonates
MH  - Female
MH  - Humans
MH  - Imidazoles
MH  - *Osteonecrosis
MH  - Ovariectomy
MH  - Sheep
OTO - NOTNLM
OT  - bisphosphonate-associated osteonecrosis of the jaw
OT  - dental implants
OT  - metabolic bone diseases
OT  - osteoporosis
OT  - zoledronic acid
EDAT- 2019/11/23 06:00
MHDA- 2020/09/15 06:00
CRDT- 2019/11/23 06:00
PHST- 2019/04/05 00:00 [received]
PHST- 2019/10/17 00:00 [revised]
PHST- 2019/11/04 00:00 [accepted]
PHST- 2019/11/23 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2019/11/23 06:00 [entrez]
AID - 10.1002/JPER.19-0213 [doi]
PST - ppublish
SO  - J Periodontol. 2020 May;91(5):628-637. doi: 10.1002/JPER.19-0213. Epub 2019 Dec 
      15.