PMID- 31756750
OWN - NLM
STAT- MEDLINE
DCOM- 20201216
LR  - 20201216
IS  - 2567-6911 (Electronic)
IS  - 0932-0814 (Linking)
VI  - 33
IP  - 2
DP  - 2020 Mar
TI  - Elevated Synovial Fluid Concentration of Monocyte Chemoattractant Protein-1 and 
      Interleukin-8 in Dogs with Osteoarthritis of the Stifle.
PG  - 147-150
LID - 10.1055/s-0039-3399525 [doi]
AB  - Chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 
      (IL-8) have been shown to cause monocyte and natural killer cell chemotaxis and 
      polymorphonuclear cell chemotaxis, respectively. Additionally, MCP-1 signalling 
      has been implicated in modulating pain. Elevated synovial fluid concentrations of 
      MCP-1 and IL-8 have been demonstrated in humans with osteoarthritis, but 
      currently there are no studies evaluating synovial MCP-1 or IL-8 concentrations 
      in dogs. Additionally, there are no canine studies evaluating the correlation 
      between these chemokines and caregiver perceived pain and mobility, as measured 
      by the clinical metrology instrument, Liverpool Osteoarthritis in Dogs. This 
      study documented elevated synovial fluid concentrations of IL-8 and MCP-1 in the 
      stifle of dogs with secondary osteoarthritis compared with normal stifles. 
      However, this study found no correlation between MCP-1 or IL-8 and Liverpool 
      Osteoarthritis in Dogs or radiographic severity of osteoarthritis.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Kleine, Stephanie A
AU  - Kleine SA
AUID- ORCID: 0000-0002-2432-7492
AD  - Department of Small Animal Medicine and Surgery, University of Georgia, Athens, 
      Georgia, United States.
FAU - Gogal, Robert M
AU  - Gogal RM
AD  - Department of Veterinary Biosciences and Diagnostic Imaging, University of 
      Georgia, Athens, Georgia, United States.
FAU - George, Clinton
AU  - George C
AD  - Department of Veterinary Biosciences and Diagnostic Imaging, University of 
      Georgia, Athens, Georgia, United States.
FAU - Thaliath, MaryAnn
AU  - Thaliath M
AD  - Department of Small Animal Medicine and Surgery, University of Georgia, Athens, 
      Georgia, United States.
FAU - Budsberg, Steven C
AU  - Budsberg SC
AD  - Department of Small Animal Medicine and Surgery, University of Georgia, Athens, 
      Georgia, United States.
AD  - Department of Veterinary Biosciences and Diagnostic Imaging, University of 
      Georgia, Athens, Georgia, United States.
LA  - eng
PT  - Journal Article
DEP - 20191122
PL  - Germany
TA  - Vet Comp Orthop Traumatol
JT  - Veterinary and comparative orthopaedics and traumatology : V.C.O.T
JID - 8906319
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Lymphotoxin-alpha)
SB  - IM
MH  - Animals
MH  - Case-Control Studies
MH  - Chemokine CCL2/chemistry/genetics/*metabolism
MH  - Dog Diseases/*metabolism
MH  - Dogs
MH  - Female
MH  - Interleukin-6/chemistry/genetics/metabolism
MH  - Interleukin-8/chemistry/genetics/*metabolism
MH  - Lymphotoxin-alpha/chemistry/genetics/metabolism
MH  - Male
MH  - Osteoarthritis/metabolism/*veterinary
MH  - Stifle/*pathology
MH  - Synovial Fluid/*chemistry
COIS- None declared.
EDAT- 2019/11/23 06:00
MHDA- 2020/12/17 06:00
CRDT- 2019/11/23 06:00
PHST- 2019/11/23 06:00 [pubmed]
PHST- 2020/12/17 06:00 [medline]
PHST- 2019/11/23 06:00 [entrez]
AID - 10.1055/s-0039-3399525 [doi]
PST - ppublish
SO  - Vet Comp Orthop Traumatol. 2020 Mar;33(2):147-150. doi: 10.1055/s-0039-3399525. 
      Epub 2019 Nov 22.