PMID- 31757529
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 230
DP  - 2020 Feb
TI  - Metal-organic frameworks for stimuli-responsive drug delivery.
PG  - 119619
LID - S0142-9612(19)30718-5 [pii]
LID - 10.1016/j.biomaterials.2019.119619 [doi]
AB  - Metal-organic framework (MOF), a novel hybrid porous material which is composited 
      by metal ions and organic linkers, has drawn increasing attention and became a 
      promising material in the biomedical field owing to their unique properties 
      including large pore volume, high surface area, tunable pore size, versatile 
      functionality and high drug loading efficiency. However, the MOF families and 
      members, and the drug release mechanisms in MOF-based stimuli-responsive drug 
      delivery systems (DDSs) are rarely summarized. Here, we systematically classified 
      the families of MOF and introduced some representative members in MOF families. 
      Moreover, the underlying drug release mechanisms were interpreted according to 
      endogenous stimuli (include pH, glutathione (GSH), adenosine-triphosphate (ATP), 
      ion, glucose, enzyme, H(2)S, and etc.) and the exogenous stimuli (include light, 
      temperature, pressure, and etc.). Furthermore, the remaining challenges and 
      future directions of DDSs based on MOF are discussed and proposed. This review 
      revealed the relationship between the structure and properties of MOF. A better 
      understanding of these release mechanisms under different stimuli would benefit 
      the designing of sophisticated DDSs based on the promising material of MOF.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Pharmaceutical Engineering, College of Chemistry and Chemical 
      Engineering, Central South University, Changsha, 410083, Hunan Province, PR 
      China.
FAU - Yan, Jianhua
AU  - Yan J
AD  - Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central 
      South University, Changsha, 410013, Hunan Province, PR China.
FAU - Wen, Nachuan
AU  - Wen N
AD  - Department of Pharmaceutical Engineering, College of Chemistry and Chemical 
      Engineering, Central South University, Changsha, 410083, Hunan Province, PR 
      China.
FAU - Xiong, Hongjie
AU  - Xiong H
AD  - Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central 
      South University, Changsha, 410013, Hunan Province, PR China.
FAU - Cai, Shundong
AU  - Cai S
AD  - Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central 
      South University, Changsha, 410013, Hunan Province, PR China.
FAU - He, Qunye
AU  - He Q
AD  - Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central 
      South University, Changsha, 410013, Hunan Province, PR China.
FAU - Hu, Yaqin
AU  - Hu Y
AD  - Department of Pharmaceutical Engineering, College of Chemistry and Chemical 
      Engineering, Central South University, Changsha, 410083, Hunan Province, PR 
      China.
FAU - Peng, Dongming
AU  - Peng D
AD  - Department of Medicinal Chemistry, School of Pharmacy, Hunan University of 
      Chinese Medicine, Changsha, 410208, Hunan Province, PR China.
FAU - Liu, Zhenbao
AU  - Liu Z
AD  - Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central 
      South University, Changsha, 410013, Hunan Province, PR China. Electronic address: 
      zhenbaoliu@csu.edu.cn.
FAU - Liu, Yanfei
AU  - Liu Y
AD  - Department of Pharmaceutical Engineering, College of Chemistry and Chemical 
      Engineering, Central South University, Changsha, 410083, Hunan Province, PR 
      China. Electronic address: liuyf@csu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191114
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Metal-Organic Frameworks)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - *Metal-Organic Frameworks
MH  - *Pharmaceutical Preparations
MH  - Porosity
OTO - NOTNLM
OT  - Drug delivery system
OT  - Drug release mechanism
OT  - Metal-organic framework
OT  - Stimuli-responsive
EDAT- 2019/11/24 06:00
MHDA- 2021/05/15 06:00
CRDT- 2019/11/24 06:00
PHST- 2019/06/15 00:00 [received]
PHST- 2019/11/09 00:00 [revised]
PHST- 2019/11/10 00:00 [accepted]
PHST- 2019/11/24 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2019/11/24 06:00 [entrez]
AID - S0142-9612(19)30718-5 [pii]
AID - 10.1016/j.biomaterials.2019.119619 [doi]
PST - ppublish
SO  - Biomaterials. 2020 Feb;230:119619. doi: 10.1016/j.biomaterials.2019.119619. Epub 
      2019 Nov 14.